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1
Myoepithelial cell and its function
100%
Sopel M. , Lis A.
Folia Histochemica et Cytobiologica. Supplement
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1996
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tom 34
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nr 1
2
Studies on histogenesis of mixed tumours on the mammary gland in bitches
84%
Smiech A. , Lopuszynski W. , Nozdryn-Plotnicki Z.
Polish Journal of Veterinary Sciences
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2002
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tom 05
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nr 4
3
The myoepithelial cell: its role in normal mammary glands and breast cancer
84%
Sopel M.
Folia Morphologica
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2010
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tom 69
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nr 1
EN
Mammary gland epithelium is composed of an inner layer of secretory cells (luminal) and an outer layer of myoepithelial cells (MEC) bordering the basal lamina which separates the epithelial layer from the extracellular matrix. Mature MECs morphologically resemble smooth muscle cells; however, they exhibit features typical for epithelial cells, such as the presence of specific cytokeratin filaments. During lactation, secretory cells synthesize milk components, which are collected in alveoli and duct lumen, and transported to the nipple as a result of MEC contraction. Although the induction of MEC contraction results from oxytocin action, also other, still unknown auto/paracrine mechanisms participate in the regulation of this process. As well as milk ejection, MECs are involved in mammary gland morphogenesis in all developmental stages, modulating proliferation and differentiation of luminal cells. They take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors. In addition, MECs are regarded as natural cancer suppressors, stabilizing the normal structure of the mammary gland, they secrete suppressor proteins (e.g. maspin) limiting cancer growth, invasiveness, and neoangiogenesis. The majority of malignant breast cancers are derived from luminal cells, whereas neoplasms of MEC origin are the most seldom and usually benign form of breast tumours. MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neigh boring luminal cells. Therefore, a deeper insight into the role of MECs in the physiology and pathology of mammary glands would allow a better understanding of cancerogenesis mechanisms and possible application of specific MEC markers in the diagnosis and therapy of breast cancer. (Folia Morphol 2010; 69, 1: 1–14)
4
ANP [Atrial Natriuretic Peptide] presence in the heart of a tunicate, Ciona intestinalis
84%
Lipari L. , Gerbino A. , Lipari D. , Farina E. V.
Folia Histochemica et Cytobiologica
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2010
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tom 48
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nr 1
68-70
5
Isolation and cultivation of endosymbiotic algae from green hydra and phylogenetic analysis of 18S rDNA sequences
84%
Kovacevic G. , Franjevic D. , Jelencic B. , Kalafatic M.
Folia Biologica
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2010
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tom 58
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nr 1-2
135-143
6
Coexpression of PTHrP and PTH-PTHrP receptor in a myoepithelial cell line derived from normal human breast
84%
Sopel M. , Lis A.
Folia Histochemica et Cytobiologica
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2000
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tom 38
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nr 2
7
Immunocytochemical localisation of PTHrP [parathormone-related peptide] in myoepithelial cells of human sweat and parotid glands
84%
Zabel M. , Murawski M. , Surdyk-Zasada J. , Salwa-Zurawska W. , Radziemski A.
Folia Histochemica et Cytobiologica
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1999
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tom 37
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nr 3
8
Immunocytochemical evaluation of metallothionein [MT] expression in myoepithelial cells of ductal mammary carcinoma and its relation to survival time: analysis of 7-year course of the disease
84%
Surowiak P. , Dziegiel P. , Matkowski R. , Kornafel J. , Wojnar A. , Zabel M.
Folia Histochemica et Cytobiologica
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2002
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tom 40
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nr 2
9
Maspin and c-erbB-2 expression in correlation with microvessel density in invasive ductal breast cancer
84%
Sopel M. , Kasprzyk I. , Berdowska I.
Folia Histochemica et Cytobiologica
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2005
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tom 43
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nr 2
10
Increased expression of gap junction protein - connexin 32 in lymph node metastases of human ductal breast cancer
67%
Kanczuga-Koda L. , Sulkowska M. , Koda M. , Rutkowski R. , Sulkowski S.
Folia Histochemica et Cytobiologica. Supplement
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2007
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tom 45
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nr 1
175-180
11
Pathogenesis of breast carcinoma. Immunohistochemical study
67%
Zoltowska A.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
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nr 1
12
Immunohistochemical study in breast carcinoma. S100-protein positive cells and neuroendocrine differentiation
67%
Zoltowska A. , Moszkowska G. , Zamorska B. , Roszkiewicz A.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
|
tom 44
|
nr 4
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