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  1. 13 Folia Histochemica et Cytobiologica
  2. 12 Journal of Physiology and Pharmacology
  3. 4 Cellular and Molecular Biology Letters
  4. 2 Acta Biochimica Polonica
  5. 2 Archivum Immunologiae et Therapiae Experimentalis
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  1. 1 2021
  2. 1 2019
  3. 1 2018
  4. 1 2017
  5. 2 2015
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  1. 3 Gorski J.
  2. 3 Kurpisz M.
  3. 3 Lewartowski B.
  4. 3 Rozwadowska N.
  5. 2 Baranowski M.
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1
Secretory granules in the atrial cardiomyocytes of guinea pigs
100%
Danowski J.
Folia Morphologica
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1991
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tom 50
|
nr 3-4
2
The role of endogenous nitric oxide in inhibition of ischemia-reperfusion-induced cardiomyocyte apoptosis
100%
Czarnowska E. , Kurzelewski M. , Beresewicz A. , Karczmarewicz E.
Folia Histochemica et Cytobiologica
|
2001
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tom 39
|
nr 2
3
IL-39 increases ROS production and promotes the phosphorylation of p38 MAPK in the apoptotic cardiomyocytes
86%
Xiong W. , Chen H. , Lu J. , Ren J. , Nie C. , Liang R. , Liu F. , Huang B. , Luo Y.
Folia Histochemica et Cytobiologica
|
2021
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tom 59
|
nr 3
4
Content available remote Biological properties of human skeletal myoblasts genetically modified to simultaneously overexpress the pro-angiogenic factors vascular endothelial growth factor-A and fibroblast growth factor-4
86%
Zimna A. , Janeczek A. , Rozwadowska N. , Fraczek M. , Kucharzewska P. , Rucinski M. , Mietkiewski T. , Kurpisz M.
Journal of Physiology and Pharmacology
|
2014
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tom 65
|
nr 2
5
Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture
86%
Mandziuk S. , Kus P. , Dudka J. , Madej-Czerwonka B. , Cendrowska-Pinkosz M. , Iwan M. , Luszczewska-Sierakowska I. , Korga A.
Medycyna Weterynaryjna
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2014
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tom 70
|
nr 05
EN
The main goal of the study was to determine whether hypoxia augments the toxicity of anticancer drugs towards cardiomyocytes. Drugs selected for this experiment were those that disturb the cardiac redox equilibrium. Cardiomyocytes were incubated for 24 h with doxorubicin, tirapazamine, and 5-fluorouracil, each at three doses, under normoxia and under 50% and 90% hypoxia. The cytotoxic effect was evaluated on the basis of the percentage of living cells, cell vitality (assessed by the MTT assay), and morphology. In addition, the oxidative marker and pH value were determined. Varied protective effects of hypoxia on cell morphology were observed in all cases except the medium concentration of tirapazamine. The 50% hypoxia prevented the toxic effects of all tested drugs. The 90% hypoxia, on the other hand, was effective against the cytotoxic action of doxorubicin and 5-fluoruracil, but the cytotoxicity of tirapazamine increased. It was found that under the 90% hypoxia the oxidative stress observed under normoxia and the 50% hypoxia was greatly reduced. The study revealed that the above drugs did not activate anaerobic glycolysis.
6
Elevation of the adenylate pool in rat cardiomyocytes by S-adenosyl-L-methionine
86%
Smolenski R. T.
Acta Biochimica Polonica
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2000
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tom 47
|
nr 4
EN
Rapid resynthesis of the adenylate pool in cardiac myocytes is important for recovery of contractility and normal function of regulatory mechanisms in the heart. Adenosine and adenine are thought to be the most effective substrates for nucleotide synthesis, but the possibility of using other compounds has been studied very little in cardiomyocytes. In the present study, the effect of S-adenosyl-L-methionine (SAM) on the adenylate pool of isolated cardiomyocytes was investigated and compared to the effect of adenine and adenosine. Adult rat cardiomyocytes were isolated using the collagenase perfusion technique. The cells were incubated in the presence of adenine derivatives for 90 min followed by nucleotide determination by HPLC. The concentrations of adenine nucleotides expressed in nmol/mg of cell protein were initially 22.1 ± 1.4, 4.0 ± 0.3 and 0.70 ± 0.08 for ATP, ADP and AMP, respectively (n = 10, ± S.E.M.), and the total adenylate pool was 26.8 ± 1.6. In the presence of 1.25 mM SAM in the medium, the adenylate pool increased by 5.2 ± 0.4 nmol/mg of cell protein, but only if 1 mM ribose was additionally present in the medium. No changes were observed with SAM alone. A similar increase (by 4.9 ± 0.6 nmol/mg protein) was observed after incubation with 1.25 mM adenine plus 1 mM ribose, but no increase was observed if ribose was omitted. Adenosine at 0.1 or 1.25 mM concentrations also caused an increase in the adenylate pool (by 5.2 ± 1.0 and 5.2 ± 0.9 nmol/mg protein, respectively), which in contrast to the SAM or adenine was independent of the additional presence of ribose. Thus, S-adenosyl-L-methionine could be used as a precursor of the adenylate pool in cardiomyocytes, which is as efficient in increasing the adenylate pool after 90 min of incubation as adenosine or adenine. Nucleotide synthesis from SAM involves the formation of adenine as an intermediate with its subsequent incorporation by adenine phosphoribosyltransferase
7
Content available Excitation-contraction coupling in cardiac muscle revisited
86%
Lewartowski B.
Journal of Physiology and Pharmacology
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2000
|
tom 51
|
nr 3
8
Characterization of the crude membrane fraction of cardiomyocytes using enzyme cytochemical markers
86%
Okruhlicova L. , Tribulova N.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 3
9
Changes of mitochondrial pathway in hypoxia-reoxygenation induced cardiomyocytes apoptosis
72%
He A. , Wang J. , Gui C. , Jiang Y. , Sun Y. , Chen T.
Folia Histochemica et Cytobiologica
|
2007
|
tom 45
|
nr 4
397-400
10
Content available remote Inhibitory effect of octyl-phenol and bisphenol A on calcium signaling in cardiomyocyte differentiation of mouse embryonic stem cells
72%
Lee J.-H. , Yoo Y.-M. , Jung E.-M. , Ahn C. , Jeung E.-B.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 3
11
Content available The effect of menadione on sarcoplasmic reticulum Ca2plus and contractions of single guinea-pig cardiomyocytes
72%
Lewartowski B. , Zdanowski K. , Wolska B. M.
Journal of Physiology and Pharmacology
|
1991
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tom 42
|
nr 2
EN
We investigated the effect of 2-methyl-1,4-naphtoquinone (Menadione) on sarcoplasmic reticulum (SR) Ca2²⁺ content and electrically stimulated contractions (ESCs) of single isolated myocytes of guinea-pig ventricular myocardium. The contractures initiated by means of microinjections of caffeine into the close vicinity of the cell were used as an indirect index of the SR Ca²⁺ content. Superfusion of the cells for 45 min with Menadione resulted in gradual disappearance of contractile respones to caffeine, prolongation of time to peak amplitude of ESCs by 48±15% and complete inhibition of postrest and postextrasystolic potentiation. These results are consistent with those of Floreani and Caipenedo (7) who found that Menadione strongly inhibits the SR Ca²⁺ ATPase. Despite depletion of the SR Ca²⁺ the amplitude of ESCs did not change which suggests that contractions were initiated in the cells treated with Menadione by Ca²⁺ derived from the sources other than the SR.
12
Content available remote Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium
72%
Kiczak L. , Tomaszek A. , Bania J. , Paslawska U. , Zacharski M. , Janiszewski A. , Rybinska I. , Dziegiel P. , von Haehling S. , Ardehali H. , Jankowska E. A. , Ponikowski P.
Journal of Physiology and Pharmacology
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2014
|
tom 65
|
nr 3
13
Atrial natriuretic peptide presence in parotid gland of human fetus at 13th week of development and in adult man
72%
Lipari L. , Farina E. V. , Buscemi M. , Gerbino A.
Folia Histochemica et Cytobiologica
|
2013
|
tom 51
|
nr 1
14
Content available remote Effect of atrial pacing on the level of bioactive sphingolipids in the heart ventricles of the rat
72%
Wojcik B. , Baranowski M. , Chabowski A. , Gorski J.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 3
15
Cardioprotective effect of 5-lipoxygenase gene [ALOX5] silencing in ischemia-reperfusion
72%
Lisovyy O. O. , Dosenko V. E. , Nagibin V. S. , Tumanovska L. V. , Korol M. O. , Surova O. V. , Moibenko O. O.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 4
687-694
EN
 It is well known that 5-lipoxygenase derivates of arachidonic acid play an important pathogenic role during myocardial infarction. Therefore, the gene encoding arachidonate 5-lipoxygenase (ALOX5) appears to be an attractive target for RNA interference (RNAi) application. In experiments on cultivated cardiomyocytes with anoxia-reoxygenation (AR) and in vivo using rat model of heart ischemia-reperfusion (IR) we determined influence of ALOX5 silencing on myocardial cell death. ALOX5 silencing was quantified using real-time PCR, semi-quantitative PCR, and evaluation of LTC4 concentration in cardiac tissue. A 4.7-fold decrease of ALOX5 expression (P < 0.05) was observed in isolated cardiomyocytes together with a reduced number of necrotic cardiomyocytes (P < 0.05), increased number live (P < 0.05) and unchanged number of apoptotic cells during AR of cardiomyocytes. Downregulation of ALOX5 expression in myocardial tissue by 19% (P < 0.05) resulted in a 3.8-fold reduction of infarct size in an open chest rat model of heart IR (P < 0.05). Thus, RNAi targeting of ALOX5 protects heart cells against IR injury both in culture and in vivo.
16
Biological and pro-angiogenic properties of genetically modified human primary myoblasts overexpressing placental growth factor in in vitro and in vivo studies
72%
Zimna A. , Wiernicki B. , Kolanowski T. , Rozwadowska N. , Malcher A. , Labedz W. , Trzeciak T. , Chojnacka K. , Bednarek-Rajewska K. , Majewski P. , Kurpisz M.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 2
17
Content available remote Peroxisome proliferator-activated receptor alpha activation inducesunfavourable changes in fatty acid composition of myocardial phospholipids
72%
Baranowski M. , Blachnio-Zabielska A. , Gorski J.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 2
13-20
EN
Peroxisome proliferator-activated receptor alpha (PPAR) plays a crucial role in the transcriptional regulation of myocardial lipid metabolism. In vitro studies on isolated cardiomyocytes showed that PPAR activation induces expression of numerous genes involved in virtually all steps of fatty acid catabolism. However, there is very few data on the effect of PPAR activation on the content and composition of myocardial lipids in vivo. Therefore, our main aim was to examine effects of selective PPAR agonist WY-14643 on the content and fatty acid composition of major lipid classes in the heart of rats fed a standard chow (STD) or a high-fat diet (HFD). In STD rats WY-14643 paradoxically decreased palmitate oxidation rate in the heart, however, in HFD animals such effect was not observed. WY-14643 markedly reduced myocardial free fatty acid and diacylglycerol content in STD rats, whereas in HFD group the opposite effect was observed. These changes reflected alterations in plasma lipid concentration which suggests that effects of WY-14643 on the heart were indirect and secondary to changes in plasma lipid availability induced by the drug. Basal myocardial glucose uptake was not affected by PPAR agonist in either group, however, glycogen content in the heart was markedly increased. WY-14643 exerted profound influence on the fatty acid composition of myocardial phospholipids in both diet groups. These changes included increased percentage of monounsaturated fatty acids and replacement of n-3 polyunsaturated fatty acids (PUFA) by those from the n-6 family. This action of WY-14643 might be detrimental to the heart since n-3 PUFA possess cardioprotective and antiarrhythmic properties.
18
Content available remote Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes
72%
Weisser-Thomas J. , Kempelmann H. , Nickenig G. , Grohe C. , Djoufack P. , Fink K. , Meyer R.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 3
19
Effects of pyrroline and pyrrolidine nitroxides on lipid peroxidation in heart tissue of rats treated with doxorubicin
72%
Koceva-Chyla A. , Gwozdzinski K. , Kochman A. , Stolarska A. , Jozwiak Z.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 1
EN
Protection from doxorubicin-induced lipid peroxidation in vivo by two pyrroline and pyrrolidine nitroxides, Pirolin, PL, and Pirolid, PD, was examined in the heart tissue of rats treated with this drug. The level of lipid peroxidation was estimated on the basis of MDA content. A considerable (threefold) increase in the MDA amount was found in heart homogenates from rats injected with doxorubicin, whereas no significant changes in MDA content compared to control were observed in cardiomyocytes treated with the nitroxides (Pirolin or Pirolid) only. Pirolin injected simultaneously with doxorubicin showed antioxidative effect and markedly attenuated lipid peroxidation in the heart tissue caused by this drug. In contrast to Pirolin, structurally related Pirolid was ineffective in the protection of heart myocytes from DOX-induced lipid peroxidation.
20
Localization of glucose-6-phosphatase activity in the rat cardiac muscle by cobalt-based cytochemistry
72%
Zinchuk V. S.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 4
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