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High Pressure Vapour-Liquid Equilibrium of Volatiles in Supercritical Carbon Dioxide

100%

Gurgenova K. , Bogeł-Łukasik R. , Wawrzyniak P.

Chemical and Process Engineering

2013

tom 34

nr 3

387-392

Binary vapour-liquid equilibrium of thymoquinone and carbon dioxide at the isothermal conditions was carried out at temperature 323.15 K and pressures from 6 to 10 MPa. The experimental data were fitted to the Soave-Redlich-Kwong equation of state. Results could be used for selection of process parameters in separation of volatiles from raw oil or for evaluation of existing separation technologies.

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Glibenclamide and Thymoquinone in Rat Plasma and Its Application to Pharmacokinetics

88%

Ahmad A. , Khan R. M. A. , Alkharfy K. M.

tom Vol. 27, no. 3

435--448

A rapid, accurate, and sensitive reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous determination and quantification of glibenclamide and thymoquinone in rat plasma in the presence of internal standard (thymol). Chromatograms were developed with methanol, acetonitrile, and buffer (50:20:30, v/v/v) solvent system on a Symmetry® C18 (5 μm, 3.9 × 150 mm) column, and pH was adjusted to 4.5 with orthophosphoric acid. Mobile phase was pumped at a flow rate of 1.5 mL min-1 with 254 nm ultraviolet (UV) detection. Validation of the method was performed in order to demonstrate its selectivity, linearity, precision, accuracy, limits of detection, and quantification (LOD and LOQ). Standard curves were linear (r2 = 0.996 and 0.999 for glibenclamide and thymoquinone) over the concentration range 0.5–50 μg Ml-1. The coefficient of variation (CV) of < 6% and accurate recovery of 87.54–105.19% for glibenclamide and CV of <5% and accurate recovery of 86.08–103.19% for thymoquinone were found to be in the selected concentration range of 0.5–50 μg Ml-1. The lower limits of detection and quantitation of the method were 0.109 and 0.332 μg Ml-1 for glibenclamide and 0.119 and 0.361 μg Ml-1 for thymoquinone, respectively. The within and between-day coefficients of variation were less than 7%. The validated method has been successfully applied to measure the plasma concentrations in a drug interaction study of glibenclamide with thymoquinone in an animal model to illustrate the scope and application of the method.

High Pressure Vapour-Liquid Equilibrium of Volatiles in Supercritical Carbon Dioxide

75%

Gurgenova K. , Bogeł-Łukasik R. , Wawrzyniak P.

Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance

63%

Dajani E. Z. , Shahwan T. G. , Dajani N. E.

nr 6

Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis

63%

Galaly S. R. , Ahmed O. M. , Mahmoud A. M.

nr 6

Wysokociśnieniowa wsadowa ekstrakcja nadkrytyczna olejku lotnego z nasion czarnuszki siewnej

51%

Gurgenova K. , Wawrzyniak P.

tom Nr 6

322-323

Wysokociśnieniowa wsadowa ekstrakcja została zastosowana do odzysku olejków eterycznych z nasion. Nadkrytyczny dwutlenek węgła został zastosowany jako rozpuszczalnik, w zakresie ciśnień od 200 do 500 bar w temperaturze 45 i 55°C. Mikroekstrakcja do fazy stałej z fazy nadpowierzchnio- wej została wykonana w połączeniu z chromatografią gazowa dla przeprowadzenia analizy wyodrębnionych frakcja lotnych. Większości składników lotnych oleju z ekstraktu zostało zidentyfikowano.

High-pressure batch extraction was applied for separation of essential oils from seeds. Experiments were performed with supercritical carbon dioxide at 45°C and 55°C and in pressure range from 200 to 500 bars. Volatile essential oil of extracts were analyzed by headspace solid-phase microextraction coupled with gas chromatography - mass spectrometry. The extract composition showed high amount of volatiles.

The role of thymoquinone in mitigating carbon tetrachloride-induced hepatocellular carcinoma in rats: Targeting the CHOP-1/JNK/p38 MAPK, NFkappaB/TNF-alpha/IL-10 and Bax/Bcl-2/Caspase-3 signalling pathways

51%

Hussein R. E. , Rashed L. A. , Aboulhoda B. E. , Abdelaziz G. M. , Abdelhady E. G. , El-aal S. A. A. , Shamseldeen A. , Khalifa M. M. , Morsi H.

Folia Biologica

2021

tom 69

nr 1