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Risk factors for basal cell carcinoma: Results from the case-control study

100%

Janković S. , Maksimović N. , Janković J. , Ražnatović M. , Marinković J. , Tomić-Spirić V.

Open Medicine

2010

tom 5

nr 6

666-673

The aim of the present case-control study was to assess the risk factors for Basal cell carcinoma (BCC) in the Montenegrin population. The study group was comprised of 100 consecutive patients with a diagnosis of BCC, while the control group consisted of patients who did not present skin cancer and who were individually matched to the cases by sex and age. The increased risk for BCC was associated with: the presence of nevi (odds ratio [OR] = 3.77; 95% confidence interval [CI] = 1.12–12.73), type of skin concerning to burn rather than to tan after repeated sun exposure in childhood or adolescence (OR = 3.14; 95% CI = 1.59–6.18), the skin reaction to burn after two or more hours of sunlight during childhood or adolescence (OR = 4.53; 95% CI = 2.37–8.63), the number of severe and painful sunburns during their lifetime(OR = 3.52; 95% CI = 1.68–7.38), outdoor work during the summer-time (OR = 2.73; 95% CI = 1.00–7.45), occupational exposure to chemicals (OR = 17.89; 95% CI = 2.82–113.52), history of eczema (OR = 4.17; 95% CI = 1.53–11.39), and history of previous BCC (OR = 3.86; 95% CI = 1.40–10.65). Our study confirms the role of environmental and constitutional factors in development of BCC.

Effect of health behaviors on presentation and condition of the skin – a preliminary report

100%

Polkowska K. , Kowalewska B. , Krajewska-Kułak E.

Progress in Health Sciences

2018

tom 8(1)

14-21

Introduction: Skin condition is determined by multiple factors, among them some which are beyond human control. However, it can be also indirectly modulated by positive health behaviors and cosmetic procedures. Objective: To analyze health behaviors and knowledge of factors determining skin condition among Polish university students. Materials and methods: The diagnostic survey, based on a questionnaire developed by the authors, included a total of 75 respondents. Results: The largest proportion of the study participants evaluated condition of their skin as moderate (41.3%). According to most respondents, skin condition is positively affected by balanced diet (78.7%), physical activity (68%), collagen (68%), calcium (41.3%) and diet rich in vegetables, fruits, fish, rice and grits. Up to 60% of the study subjects declared present or past intake of dietary supplements, 44% used dedicated cosmetics for facial skincare, and 58.7% consumed 1-2 liters of fluids per day. Sweetened beverages, alcohol, excess of coffee, tea and herbal infusions were considered unfavorable for skin health, similar to stimulants, such as cigarettes, alcohol, drugs and coffee. Up to 38.7% of the respondents declared a sedentary lifestyle. In the participants’ opinion, stimulants (85.3%), lack of hygiene (76%), inappropriate fluid repletion (68%) and too low physical activity (62.7%) are the most harmful factors for skin health. Conclusions: The study participants had basic knowledge of health behaviors and their beneficial or detrimental effects on the condition of human skin. The majority of the respondents used skincare cosmetics dedicated to a given body area. Keywords: Skin, health behaviors, knowledge

Investigation of permeation of acyclovir through skin using alaptide

75%

Cernikova A. , Bobal P. , Bobalova J. , Dohnal J. , Jampilek J.

Acta Chromatographica

2018

tom Vol. 30, no. 1

62--65

The investigation deals with the affection of the permeation of acyclovir through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicles of phosphate buffer (pH 7.4) and propylene glycol–water (1:1) using synthesised (S)-8-methyl-6,9-diazaspiro[4.5]decane-7,10-dione, alaptide as a transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) relative to the amount of acyclovir. At the first hour after application, the permeated amount of acyclovir from propylene glycol–water system, simulating semisolid dosage forms, was ca. four-fold higher than from the formulation without alaptide. Despite that the enhancement ratio of alaptide in a steady state was 1.7, the pseudo-enhancement ratio of alaptide in the time range of first to third hour was 2.3. Both enhancement ratios indicate that alaptide modifies skin structure, while the short-term application of the alaptide formulation seems to be more advantageous.