Wyniki wyszukiwania - Biblioteka Nauki

1

Choroba nowotworowa – w obliczu zagrożenia życia

100%

Paul-Kańska J. , Wydział Organizacji i Zarządzania Politechniki Łódzkiej

Acta Universitatis Lodziensis. Folia Psychologica

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2007

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tom 11

EN

The article presents a multi – dimensional look at the issue of coping with stress, situating health monitoring and the sense of self – effectiveness in people with recognized cancer. The results of self – studies were displayed, showing whether and to what degree the strategies of managing the disease depend on the subjects’ sex. The existence of the relationship between the tested variables (situating health monitoring and the sense of self – effectiveness) and the strategies of coping with the disease stress, was proved.

2

Hyalinising clear cell carcinoma of salivary gland: a case report

100%

Michał Osuchowski M. , Dorota Bartusik-Aebisher D. , Ewa Kaznowska E. , David Aebisher D.

European Journal of Clinical and Experimental Medicine

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2020

|

nr 2

127-130

EN

Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.

3

Satisfaction with life after radical treatment of cancer

100%

Nowicki A. , Duba P. , Lemanowicz M.

OncoReview

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2017

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tom 7

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nr 4

192-198

EN

Introduction: Cancer treatment is multidisciplinary in its character and places a heavy burden on the patient. Quality of life is a concept that is closely related to the satisfaction with life. Cancer patients’ satisfaction with life, especially after recovery, is an increasingly examined indicator of treatment quality. Aim of the study: Evaluation of satisfaction with life in patients after radical cancer treatment. Material and methods: The study included 100 people, 81 women and 19 men of all ages, following radical treatment of various cancers. The study was conducted in 2016 at the Centre of Oncology in Bydgoszcz. The study used the Satisfaction with Life Scale (SWLS), adapted by Z. Juczyński, as well as a sociodemographic data questionnaire. Results: In general, cancer patients have an average level of satisfaction with life – the average score was 22.37 and 6.19 sten. The greatest satisfaction with life (average points) was reported for professionally active people – 22.67, patients between 41–50 years old – 23.5, patients with secondary education – 23.4, and patients with at least one child – 22.73, though the differences were not statistically significant. Additionally, patients 3–5 years after treatment declared a higher satisfaction with life – 23.05, as did patients without concomitant diseases – 22.77, though again the results were statistically non-significant. Conclusions: In general, patients after radical anti-cancer treatment have an average satisfaction with life, and in half of them satisfaction with life is high, regardless of the duration and type of cancer. Sociodemographic factors have no impact on the satisfaction with life scores.

4

Kinin-generating cellular model obtained from human glioblastoma cell line U-373

80%

Guevara-Lora I. , Blonska B. , Faussner A. , Kozik A.

Acta Biochimica Polonica

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2013

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tom 60

|

nr 3

299-305

EN

Kinins, a group of important pro-inflammatory peptides, are abundantly found in tissues and biological fluids of cancer patients. Bradykinin, the major representative of kinins, induces vascular permeability and, in consequence, promotes tumor expansion. Additionally, the kinin-induced inflammatory responses, especially those mediated by kinin metabolites without the C-terminal arginine residue, lead to enhanced tumor growth. The present study aimed at analyzing the ability of the human glioblastoma cell line U-373, derived from a malignant tumor, to produce kinin peptides. The proteins involved in kinin generation, i.e., the kininogens and the kallikreins, were shown to be expressed in these cells. Moreover, tumor necrosis factor α, a proinflammatory cytokine that mediates tumorigenesis, was found to enhance the expression of enzymes associated with kinin production. The strong binding of kininogen to the cell surface and the enzymatic degradation of this protein by cells suggest the activation of kinin-generating systems. Indeed, glioblastoma cells, pre-treated with tumor necrosis factor α, released kinin peptides from exogenous kininogen. The expression of kinin receptors in these cells was also shown to increase under the influence of this cytokine. Our results suggest that the human glioblastoma cell line U-373 constitutes a good cellular model that can be helpful in cancer research focused on kinin-induced inflammation. Furthermore, our findings can contribute to new approaches in cancer treatment with the use of kinin receptor antagonists and inhibitors of kinin production.

5

Cancer on the Holodeck: Metaphors and Cultural Construction of a Disease through Digital Games

80%

Navarro-Sierra N. , Carrillo-Vera J. A. , Gómez-García S.

Acta Ludologica

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2020

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tom 3

|

nr 2

4-20

EN

A study from the OECD published that Cancer is one of the main causes of mortality in developed societies, with remarkably high prevalence, incidence and mortality rates for both sexes. This study closely examines nine digital games to elucidate how they conceptualize a disease like cancer around a narrative concerning the sickness, patients, treatments and outcomes. Discourse and content analysis techniques were applied to the message contained in the games looking to illuminate the connection between the narrative core, the audio-visual representation and the interactive aspects of the game, within the parameters of values-conscious design applied to digital games. This provides some evidence about the cultural and visual aspects of how game designers conceptualize the disease as a part of society. This research uncovers culturally embedded themes and reveals the prevalence of metaphor use in cancer discourse which relied on science, social support and spiritual convictions for social empowerment, building empathy and identification.

6

Konsekwencje choroby nowotworowej w rodzinie

80%

Rospęk P.

Studia Pastoralne

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2020

|

tom 16

126-141

EN

Malignant tumor is the second most frequent cause of death in Poland. A steady increase in cancer mortality has been observed in Poland. The introduction of modern research methods has contributed to an increase in cancer detection and enhanced therapeutic effects. New medical achievements, the introduction of new drugs or more optimal treatment techniques can become a source of further improvement of the situation. The appearance of cancer in the family completely changes the lives of its individual members. The way of thinking, feelings, actions, the hierarchy of goals and values change depending on the phase of the disease and the progress of treatment. Nevertheless, the fight against cancer in the family is still an issue little known in Polish psycho-oncology. The article shows the impact of cancer on the patient’s family, focusing on the sociological, psychological and spiritual dimensions of attitudes and reactions of families towards oncologically ill relatives. One of the author’s main goals is to examine how fear and anxiety develop in families affected by cancer.

7

Isolation of low-molecular albumins of 2S fraction from soybean (Glycine max (L.) Merrill)

80%

Galbas M. , Porzucek F. , Woźniak A. , Słomski R. , Selwet M.

Acta Biochimica Polonica

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2013

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tom 60

|

nr 1

107-110

EN

Numerous studies have shown that consumption of soybean products decrease the risk of cancers in humans. Experiments at the molecular level have demonstrated that in most cases proteins and peptides are responsible for the anticancer properties of soybeen. Special attention should be paid to lunasin - a peptide described for the first time 16 years ago. Due to its structure it causes i.a., inhibition of cancer cell proliferation. A novel procedure for the isolation and purification of low-molecular-mass 2S soybean albumin protein is described in the present paper. A fraction of four peptides one of them corresponding to molecular mass and isoelectric point characteristic for lunasin. The obtained peptides decreased on the rate of HeLa cell proliferation.

8

Biomineralogy of cancer

80%

Pawlikowski M.

Auxiliary Sciences in Archaeology, Preservation of Relics and Environmental Engineering

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2018

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tom nr 25

66--70

9

WIDEOSKOP PDD firmy medi.com do diagnostyki nowotworów i stanów przednowotworowych metodą fotodynamiczną

80%

Gacek P.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

|

2007

|

tom Vol. 13, nr 1

74-76

PL

W pracy omówiono zasadę działania fotodynamicznej terapii (PDT) i diagnostyki (PDD) nowotworów oraz przedstawiono nowatorski system diagnostyczny wspomagający tę metodę. Diagnostyka i terapia fotodynamiczną jest alternatywą dla inwazyjnych metod rozpoznawania i leczenia nowotworów. Bazuje na selektywnej akumulacji fotoaktywowanego leku (fotouczułacza) w tkankach zmienionych nowotworowo. Metoda diagnostyczna wykorzystuje światło niebieskie, które wzbudza czerwoną fluorescencję fotouczułacza, wspomagając lokalizację patologii. Zaletą tej metody jest nieinwazyjność lub minimalna inwazyjność. Badanie jest dobrze tolerowane przez pacjentów, daje niemal natychmiastowe wyniki, można je stosować wielokrotnie, nie wywołując przy tym efektów ubocznych.

10

Potentiometric detection of the metabolic activity of human tumor cells

80%

Kwapiszewska K. , Stępień K. , Sendys P. , Chudy M. , Brzózka Z.

Challenges of Modern Technology

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2013

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tom Vol. 4, no. 1

41--46

EN

Monitoring of cellular viability is a key part of toxicological assays in vitro. On-line monitoring of metabolic activity would be particularly useful for evaluation of responses to potential therapeutic compounds. Current assays are mostly based on fluorescent dyes and optical detection methods. These methods offer high sensitivity and specificity, however are not suitable for long-term on-line observations. Electrochemical methods can be an alternative for current protocols. Electrochemical detection is low cost and label-free, therefore suitable for long-term cell culture monitoring. In this work investigations on human cancer cells viability will be presented. Cells were cultured as two-dimensional monolayer or three-dimensional spheroids. Different cell culture media were examined. Potentiometric detection was used for continuous monitoring of cell culture as well as end-point investigations. Different growth phases were identified using applied method. Finally, response to an anticancer drug was successfully observed.

11

Nutrigenomics – a new approach for cancer prevention and treatment

80%

Piątek W. , Milewska M. , Krasowska U. , Terlikowska, K.M

Progress in Health Sciences

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2018

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tom 8(1)

151-157

EN

Diet is a major environmental factor which maintains metabolic balance and body homeostasis. The aim of the study was to present the latest reports on the biological activity of the food compounds in a critical review. It has been shown that bioactive substances supplied with food e.g. polyphenols, flavonoids or phenolic acids exhibit immunomodulatory and anti-inflammatory fun-ctions. What is more, they favourably downregulate major oncogenes and enhance suppressors’ expression. Studies show that these substances can be an important component of cancer prevention and treatment. However, there are micronutrients like iron or copper which elevated levels in cancer cells occurs and should be considered as a therapeutic targets.

12

Purine nucleoside analogs in the therapy of cancer and neuroinflammation

80%

Savić D. , Stanković T. , Lavrnja I. , Podolski-Renić A. , Banković J. , Peković S. , Stojiljković M. , Rakić L. , Ruždijić S. , Pešić M.

Molecular inhibitors in targeted therapy

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2015

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tom 1

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nr 1

EN

Purine nucleoside analogs have been in clinical use for almost 50 years. At the beginning developed as antiviral agents, later their efficacy was demonstrated in cancer treatment, especially hematological malignances. The approval of new purine nucleoside analogs by US Food and Drug Administration (FDA) over the past decade implies that the interest for these drugs still exists. Here, we review new nucleoside analogs that are currently in preclinical or clinical development as anticancer agents. In addition, we highlight the potential for implementation of these drugs in other pathological conditions, particularly in neuroinflammation.

13

The incidence of malignant tumor among the adult population of Belarus, undergone to influence of radiation owing to the accident on the Chernobyl atomic power station

80%

Kotava A. , Sasnouskaya A.

Progress in Health Sciences

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2011

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tom 1

|

nr 1

14-20

EN

Purpose: We presented results of long-term monitoring of incidence malignant tumor among the adult population of Belarus, according to the Belarus state register of the persons, undergone to influence of radiation owing the accident on the Chernobyl atomic power station. Material and methods: The analysis of primary incidence of malignant tumor among various categories of the population living in Belarus and undergone the influence of ionizing radiation owing to the accident on the Chernobyl atomic power station is lead. The analysis is leading on the directly age-standardized parameters designed with the use of the world standard population. Levels, dynamics and growth rate in comparison with a similar parameters control group were estimated. Those localizations of a cancer which taking into account world experience can be radiation - induced to have been included in research only. Results: The carried out research has revealed of statistically excess of a level and rate of incidence malignant tumors lung, stomach, colon, skin, urinary bladder among various categories of the population of the injured from Chernobyl accident in comparison with the control group. The most expressed distinctions were characteristic of the liquidators. The changes of levels and dynamics of incidence are revealed for organs of the breath, digestion, urinary system, which are the basic ways of receipt and deducing radionuclide’s. Among all observable groups of the adult population the significant excess of incidence by thyroid cancer is revealed. Conclusion: Among the adult population of Belarus should continue to monitor the incidence of malignant tumor, provide an assessment of doses to different groups of affected people, plan and conduct analytical radiation-epidemiological studies.

14

Novel oral anticoagulants in the treatment of cancer patients

80%

Biernacka R. , Lewandowski T. , Andrzejuk J. , Szmyd M.

OncoReview

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2014

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tom 4

|

nr 1

A11-17

EN

Cancer and its treatment are well-recognized risk factors for venous thromboembolism. The risk of thrombotic complications increases 4–7-fold in cancer patients and coexistence of both pathologies is associated with shorter survival. Incidence of thrombosis depends on the tumour type, antineoplastic and supportive therapy, and patient-related factors such as age, physical activity and comorbidities. Current recommendations of scientific societies indicate a dominant role of low molecular weight heparins in the treatment and prevention of venous thromboembolism in cancer patients. Long duration of the anticoagulant effect, and the subcutaneous administration route of heparins call for a safer therapeutic option, and one that would be more convenient for the patient. New oral anticoagulants: dabigatran, rivaroxaban, and apixaban, are indicated as prevention of venous thromboembolism following an orthopaedic surgery, and as stroke prevention in nonvalvular atrial fibrillation, with rivaroxaban also applied in the treatment of acute deep vein thrombosis and pulmonary embolism. In the trials evaluating the efficacy of novel oral anticoagulants, they have been compared with enoxaparin or vitamin K antagonists. Cancer patients accounted for a small percentage of the trial population, and they were rarely analysed in subgroup analysis. It was only in the phase II ADVOCATE study that the target group were patients receiving chemotherapy. Direct comparison between test drug and low molecular weight heparins was not performed. The currently available study results do not allow us to recommend the new oral anticoagulants for the treatment and prevention of venous thromboembolism associated with cancer.

15

Physiopathological Implications of 7TM Receptors

80%

Cygankiewicz A. I.

Acta Universitatis Lodziensis. Folia Biologica et Oecologica

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2010

|

tom 6

33-47

EN

Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways. Divergence of receptor types, their ligands and signaling pathways makes 7TM receptors important factors in pathology of many diseases. This review focused on the main diseases in which involvement of 7TM receptors was established e.g., retinitis pigmentosa, severe obesity, and dwarfism. Recent findings of aberrant expression of 7TM receptors in development of cancer were also summarized.

16

Role of image processing in the cancer diagnosis

80%

Detyna J. , Jeleń Ł. , Jeleń M.

Bio-Algorithms and Med-Systems

|

2011

|

tom Vol. 7, no. 4

5--9

EN

Cancer is still one of the most deadly diseases. It is a well known fact that the early diagnosis is crucial and allows for the successful treatment while cancers diagnosed in their late stage are almost impossible to treat. For precise and objective diagnosis there is a need for a computerized method for cytological image processing, which is an integral part of a diagnosis process. In this work we present a classification system for grading cancer malignancy. In particular, issues of image processing in the aspect of medical diagnosis presented by prof. R. Tadeusiewicz and Dr. J. Śmietański in [1].

17

Percutaneous retrieval of a fractured portacath fragment in two patients undergoing long-term chemotherapy

80%

Norwa J. , Darocha S. , Dobosiewicz A. , Koteja A. , Pietrasik A. , Pietura R. , Torbicki A. , Szmit S. , Kurzyna M.

OncoReview

|

2016

|

tom 6

|

nr 2

A57-61

EN

The paper discusses two clinical cases of cancer patients undergoing chemotherapy, in whom fractured and displaced tips of portacath catheters were revealed based on plain chest imaging. In the first case, the portacath fragment migrated to the left pulmonary artery, with the missing catheter tip revealed during the procedure of port removal due to its occlusion, with no other prior clinical symptoms. In the second case, the catheter broke off at the level of its entry into the subclavian vein, and migrated into the right cardiac ventricle, which was accompanied by mild pain and oedema in the subclavicular region. Both patients underwent successful procedures of percutaneous foreign body retrieval with the use of endovascular snares. The procedures were performed via femoral vein access, with no complications.

18

Variable order 3D models of bone remodelling

80%

Valério D. , Neto J. , Vinga S.

|

nr 3

19

Assessment of nutritional status of patients with cancer who are qualified for home enteral nutrition – a retrospective analysis

80%

Kaźmierczak-Siedlecka K. , Folwarski M. , Jankowska B. , Spychalski P. , Szafrański W. , Baran M. , Makarewicz W. , Bryl E.

European Journal of Translational and Clinical Medicine

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2020

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tom 3

|

nr 1

16-23

EN

Background: Patients with cancer are at risk of malnutrition. The aim of this study is to assess the nutritional status of patients with cancer who are qualified for home enteral nutrition. Secondary aim is to compare the nutritional status of patients with gastric cancer and with esophageal cancer. Material and methods: Retrospective analysis of medical documentation of 84 participants with cancer who were qualified for home enteral nutrition in Nutritional Counselling Center Copernicus in Gdansk in 2009-2015 was performed. Assessment of nutritional status included body mass index, the level of total protein and albumin in blood serum, total lymphocyte count, and Nutritional Risk Score 2002 method. Results: Patients with gastric cancer most often presented albumin deficiency in comparison with patients with esophageal cancer (p=0.02). The low level of total lymphocyte count in 1mm3 of peripheral blood was observed in 47.6% participants. All the patients qualified for home enteral nutrition received at least 3 points in NRS 2002 method and most often 5 points (40.4%). Conclusions: All patients required nutritional treatment. Notwithstanding, the nutritional status of patients varied. Hypoalbuminemia was observed more often in patients with gastric cancer in comparison with patients with esophageal cancer.

20

Seizure as first manifestation of endocarditis in a patient with metastatic pancreatic adenocarcinoma: a case report

80%

Ciuffo Almeida M. P. , Santos da Silva Costa I. B. , Feres de Almeida M. C. , Bittencourt Viana Cruz C. B. , Itala Rizk S. , Abrahão Hajjar L.

OncoReview

|

2019

|

tom 9

|

nr 4

92-95

EN

Nonbacterial thrombotic endocarditis is a potentially overlooked condition that involves the formation of sterile fibrin vegetations on heart valve leaflets in cancer patients. This condition can lead to valvular dysfunction, heart failure and systemic embolization. The pathogenesis depends on hypercoagulable states which are common in malignancy scenarios. Diagnosis requires the presence of valvular vegetations and the absence of infection.