Wyniki wyszukiwania - Biblioteka Nauki

1

Association between weight status and recreational drug abuse in Korean adolescents

100%

Baek S.-I. , So W.-Y.

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nr 2

224-229

EN

The purpose of this study was to investigate the relationship between weight status and recreational drug use in Korean adolescents. A total of 72,399 adolescent students (38,152 boys and 34,247 girls) from the middle first to high third grade participated in the 5th Korea Youth Risk Behaviour Web-based Survey (KYRBWS-V) project in 2009. They were assessed for body mass index (BMI) and recreational drug abuse. The associations between BMI and recreational drug use were examined using multivariable logistic regression analysis after adjusting for the covariate variables of age, smoking frequency and cigarette consumption, frequency of alcohol consumption and severe alcohol intoxication, amount of alcohol consumed, parents’ education level, economic status, sedentary activities during the week, mental stress, sleep duration, frequency of vigorous and moderate physical activities, and muscular strength exercises during the week. For boys, the odds ratio (OR) (95% confidence interval [CI]) between overweight and drug use were 0.990 (0.723–1.356; p = 0.950) for almost none, 0.939 (0.521–1.693; p = 0.834) for past use, and 0.791 (0.385–1.624; p = 0.523) for present use. The OR (95% CI) between obesity and drug use was 0.731(0.508–1.052; p = 0.091) for almost none, 0.755 (0.389–1.465; p = 0.407) for past use, and 0.701 (0.314–1.565; p = 0.386) for present use. For girls, the OR (95% CI) between overweight and drug use was 1.112 (0.702–1.763; p = 0.650) for almost none, 1.103 (0.464–2.619; p = 0.825) for past use, and 0.927 (0.267–3.218; p = 0.905) for present use. The OR (95% CI) between obesity and drug abuse was 0.594 (0.261–1.352; p = 0.215) for almost none, 1.318 (0.462–3.764; p = 606) for past use, and <0.001(<0.001–<0.001; p = 0.998) for present use. We concluded that recreational drug use had no correlation with overweight and obesity in Korean adolescents.

2

Effect of Modified High Intensity Interval Training on Fat Loss

100%

Dominic D. , Kishore S.

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nr 3

49-56

EN

Exercise has multiple health benefits and is a critical component in managing overweight and obesity. High Intensity Interval Training (HIIT) involves brief high-intensity anaerobic exercise followed by rest or very low intensity exercise. 24 men and women (age 18–60 years) volunteered to participate in a 6 weeks of modified HIIT exercises program where whole body functional training exercises was provided. Their body weight, body mass index, waist to hip ratio and skin fold fat were measured at the beginning and at the end of the 6 weeks duration. Statistical significance was found between the variables at p < 0.05. The results showed that a Modified HIIT exercise Program based on Body weight training results in considerable decrease in level of sub-cutaneous adiposity up to 77.8%. Obesity and overweight have become complex pandemic disorders where in physical inactivity and lack of time to exercise plays a major role leading to various complications. Reduction in adiposity through structured exercises protocols will improve body composition and Cardio-metabolic health . Novel interventions such as modified HIIT serve as the perfect pathway to address the time factor and enhancement of physical activity as well.

3

Obesity – is it really so bad for a patient with coronary heart disease?

100%

Pogorzelski S. , Kuźma Ł. , Struniawski K. , Wróblewski D. , Gajewska_Bachórzewska, H , Dobrzycki S.

Progress in Health Sciences

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2018

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tom 8(2)

194-201

EN

According to American Obesity Medicine Association obesity is a chronic, relapsing, multifactorial, neurobehavioral disease, wherein an increase in body fat promotes adipose tissue dysfunction and abnormal fat mass physical forces, resulting in adverse metabolic, biomechanical, and psychosocial health consequences. Obesity has been renowned as a risk factor of cardiovascular, endocrinological, orthopedic and many other diseases. But for the last two decades, there have been many reports of beneficial influence of overweight or obesity on patients with coronary heart disease. This phenomenon got a name of obesity paradox. It’s existence is a matter of lively discussion in medical world, and even if true, the protecting mechanisms of obesity need much deeper understanding.

4

Effects of indoor cycling associated with diet on body composition and serum lipids

100%

do Valle V. , de Mello D. , Fortes M. d. S. , Dantas E.

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tom 1

11-15

EN

Study aim: To determine the effects of indoor cycling training combined with restricted diet, lasting 12 weeks, on serum lipid concentrations in obese women.Material and methods: Twenty women aged 23.8 ± 3.6 years were randomly assigned into two groups: control (C) and experimental (E), the latter subjected to indoor cycling at various loads, 3 sessions weekly, every session lasting 45 min, combined with restricted diet (about 1200 kcal daily) for 12 weeks. The following variables were recorded: body height and mass, BMI, relative body fat content (from 7 skinfolds), fat-free mass, triglycerides, cholesterol and lipoproteins (HDL, LDL, VLDL).Results: Significant increase in HDL and significant decreases in all other variables (except body height) were noted only in the experimental group.Conclusions: Indoor cycling associated with restricted diet is an excellent option in controlling obesity and serum lipids.

5

The effect of orlistat on body weight in obese Czech adults

100%

Pavlík V. , Fajfrová J. , Drahokoupilová E.

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nr 5

553-557

6

The effect of milk consumption on bone mass density in obese and thin adult women

100%

Habibzadeh N.

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2010

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tom 2

81-84

EN

Study aim: To assess the effect of milk consumption lasting two months on BMD of obese and thin young women.Material and methods: A group of 38 untrained women (18 obese [O] - BMI>30, and 20 thin [T] - BMI<20), aged 20 - 25, years participated in the study. They were randomly assigned into BMI-matched experimental [E] or control [C] groups containing 9 obese and 10 thin subjects each. Experimental groups were given 2 glasses of milk (600 mg/day of calcium; fat content 1.5%) for 2 months, 3 days a week. At the beginning (Pre) and at the end (Post) of the study, bone mass density (BMD) at the hip and spine (L2-L4) was measured using DEXA technique, and oestrogens, calcium and phosphorus were determined in serum. Body fat content (%F) and lean body mass (LBM) were determined using the bioimpedance (BIA) technique.Results: In both experimental groups BMD significantly (p<0.05 - 0.001) increased in both areas by 4 - 7%. In the TE group, %F significantly (p<0.05) decreased by 8% and LBM significantly (p<0.001) increased by 3%. Serum calcium decreased in all groups except OC by 3 - 5% (p<0.05 - 0.01) and oestrogens markedly increased in all groups except TC.Conclusion: The data suggest that adequate milk intake (thus calcium) in adolescence is an indicator of attaining adequate bone mass density, thus preventing the risk of osteoporosis.

7

B-cell activating factor (BAFF) - a new factor linking immunity to diet?

88%

Bienertova-Vasku J. , Bienert P. , Zlamal F. , Tomandl J. , Forejt M. , Tomandlova M. , Vavrina M. , Kudelková J. , Splichal Z. , Vasku A.

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nr 3

275-283

EN

B cell activation factor (BAFF) is a recently discovered member of the TNF ligand superfamily secreted by adipocytes, previously linked to autoimmune and lymphoproliferative disease. The aim of this study was to investigate the relationship between BAFF plasma levels and the non-modified, usual dietary composition as well as obesity-related anthropometric parameters in a cohort of 58 obese and non-obese Central-European Caucasian individuals. We found that BAFF had an independent predictive role for percentage of body fat; moreover, BAFF levels were correlated with waist and hip circumference. BAFF plasma levels were also significantly correlated with investigated dietary composition based on the 7-day food records, as the BAFF levels correlated with the percentage of energy derived from the carbohydrates and with energy derived from the dietary fat. Our results suggest that BAFF may play a role in linking the immune status and metabolic response to diet.

8

Differences in the body composition and biochemistry in women grouped as normal-weight, overweight and obese according to body mass index and their relation with cardiometabolic risk

88%

Ozenoglu A. , Ugurlu S. , Can G. , Sarkis C. , Demirel Y.

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nr 6

724-732

EN

Morbidity of obesity-related diseases tends to increase due to a rise in the body mass index (BMI). We aimed to investigate how the body composition and biochemical parameters change while BMI increases in adult women were categorized as so: as normal weight, overweight and obese. Our objectives are to study the effects of those changes in the development of metabolic disturbances and to find out which parameters are the most sensitive to predict cardiometabolic risks. Three hundred and twenty two records of adult women (mean age: 38.62±12.71 year) who admitted to our unit concerning about losing or preserving their weights, were analyzed in the study. All patients had undergone anthropometric measurements and body composition analyses as well as some biochemical tests. Body composition analyses were performed by means of the Bioelectrical Impedance Analyzer (BIA). Increase in BMI significantly increased the body fat, blood sugar, insulin, triglyceride and uric acid levels. BMI and circumference of the waist were significantly and negatively correlated with the ratio of body water and lean mass/fat mass. However they were positively correlated with the ratio of fat mass and basal metabolism. Furthermore, it was also found that BMI and circumference of the waist were significantly and positively correlated with level of fasting blood sugar, insulin, triglyceride, homeostasis model assessment insulin resistance (HOMA-IR), uric acid and fibrinogen levels, and negatively correlated with high density lipoprotein (HDL) cholesterol level. In multiple regression analyses, circumference of waist measurements was significantly correlated with insulin, triglyseride and HDL, whereas the correlation between BMI and these parameters was not found significant. Total body fat mass (as %) showed significant correlation only with HDL-C level. It could be said that obesity which is a disorder that causes many health complications and affects the quality of life in the short and long term could be prevented or cured by keeping negative environmental conditions under control. According to our results, visceral adipose tissue (VAT) measurement was thought to be more related for metabolic and cardiovascular disorders rather than BMI. We also propose to test fasting blood glucose, insulin, triglyceride, HDL, fibrinogen, homocystein (HOM) levels along with VAT measurements to predict more truly about not only global cardiometabolic risk but also dementia in later life.

9

The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

88%

Ilie I. , Pepene C. , Marian I. , Mocan T. , Hazi G. , Drăgotoiu G. , Ilie R. , Mocan L. , Duncea I.

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nr 1

64-75

EN

The study investigated the presence of early vascular damage and chronic inflammation, and their relationships with hormonal and metabolic parameters in 45 young women with PCOS in comparison with thirty-two healthy age-matched controls. Hormonal and metabolic profiles, high sensitivity C-reactive protein (hsCRP), tumoral necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), brachial flow-mediated vasodilation (FMD) and carotid intima-media thickness (CIMT) were determined in both groups. Compared with the controls, women with PCOS had significantly lower FMD and respectively higher ET-1 levels (p=0.001). No differences were observed between the groups in terms of CIMT or inflammatory markers. In the PCOS group, ET-1 levels were significantly correlated with only testosterone concentrations (r = 0.31, p = 0.037), whereas the hsCRP levels were independently predicted only by body mass index (BMI). Within the total group, the PCOS status was the sole significant predictor of ET-1 levels and the only independent predictor of FMD. In conclusion, there is evidence of endothelial dysfunction associated with increased levels of androgen hormones in young women with PCOS. The combination of endothelial dysfunction and coexistent obesity promoting inflammation contributes to the progression of atherogenesis in PCOS. The PCOS status should be regarded as a predictor marker of cardiovascular risk, along with well-known cardiovascular risk factors.

10

sRAGE is associated with low waist circumference and Hb levels in NAFLD

88%

Hyogo H. , Yamagishi S.-i. , Maeda S. , Nakahara T. , Kimura Y. , Chayama K.

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nr 6

830-834

EN

Advanced glycation end products (AGEs) and the receptor RAGE interaction is involved in nonalcoholic fatty liver disease (NAFLD). Although exogenously administered soluble RAGE (sRAGE) has been shown to block the harmful effects of AGEs in animal models, there is still controversy about the role of sRAGE in humans. We examined here which anthropometric, metabolic and clinical variables were independent correlates of sRAGE levels in NAFLD patients. The study involved 77 biopsy-proven, unmedictaed NAFLD patients (44 male and 33 female) with a mean age of 43.4±13.0 years old. We examined which anthropometric, metabolic and clinical variables, including liver steatosis and fibrosis markers, are independently associated with serum levels of sRAGE. Mean serum levels of sRAGE were 710.7±290.2 pg/mL. Univariate analysis revealed that waist circumference (inversely), hemoglobin (inversely), number of white blood cells (inversely), total-bilirubin (inversely), free fatty acid (inversely), ferritin (inversely), and HbA1c (inversely) were significantly correlated with serum levels of sRAGE. In multiple stepwise regression analysis, waist circumference (p<0.01, inversely) and hemoglobin (p<0.01, inversely) were independently associated with serum levels of sRAGE (R2=0.176). The present study reveals that low serum levels of sRAGE are independently associated with waist circumference and hemoglobin in patients with NAFLD.

11

Analyzing selected risk factors for the development of kidney cancer

88%

Kollárová H. , Azeem-Skřejpková K. , Tomášková H. , Horáková D. , Magnusková S. , Janout V.

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nr 1

78-84

EN

The aim of this study was to determine influence of selected lifestyle factors on kidney cancer. The study brings data from two centres of international multicentric hospital-based analytical observational case-control studies. Data were obtained from a group of 300 patients newly diagnosed with kidney cancer (ICD-O-2 code C64) and 335 controls from two centres in the Czech Republic. Results showed that smoking increased OR to 1.09 (95% CI 0.77–1.55) and 1.06 (95% CI 0.73–1.52), but the results were not statistically significant. Obesity (BMI⩾30) created adjusted OR 1.71 (95% CI 1.11–2.66) and 1.44 (95% CI 0.91–2.28), showing a minor, statistically insignificant, effect of obesity on the development of kidney cancer. For hypertension, adjusted OR was 1.73 (95% CI 1.25–2.40), suggesting a minor to moderate effect of hypertension on kidney cancer. The analysis results showed a positive association between hereditary predisposition and the development of kidney cancer with an OR of 1.97 (95% CI 1.41–2.76) and 1.97 (95% CI 1.40–2.77) depending on the model of adjustment. The reasons for the high incidence of kidney cancer are not fully understood. Genetic polymorphisms, together with other lifestyle and environmental factors, are likely to contribute to various rates of kidney cancer incidence throughout the world.

12

Physical self-concept, trait depression and readiness for physical activity of obese patients

88%

Boros S. , Halmy L.

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tom 1

60-62

EN

Study aim: To assess the physical self-concept, trait depression and readiness for physical activity in relation to the degree of obesity.Material and methods: Obese (Grade I and II; n = 59) and morbidly obese (Grade III; n = 42) patients aged 30 - 66 years, as well as 83 non-obese college students aged 30 ± 7.3 years were studied. Physical self-concept, trait depression and readiness for physical activity were determined apart from anthropometric measurements including body fat content.Results: Physical self-concept was inversely associated with the degree of obesity. Morbidly obese (Grade III) who were more satisfied with their body were also more ready for physical activity (r = 0.394; p<0.01). Trait depression and physical self-concept were negatively correlated in both groups.Conclusion: Body satisfaction may play an important role in the protection against depression and enhance the readiness for physical activity of obese patients.

13

Effect of Tetracarpidium conophorum nut extracts on body and organ weights of monosodium glutamate obesity-induced in albino wistar rats

88%

Abraham E. J. , Atangwho I. J. , Achukee C. K. , Udoubom I. A. , Abang C. , Ekon I. E. , Nwankwor K. C.

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tom 52

1-11

EN

This study aimed to assess the effect of Tetracarpidium conophorum nut extracts on body weight and organ/tissue weight in monosodium glutamate obesity- induced in Wistar rats. With the global obesity epidemic lacking an effective cure, this investigation holds significance. Twenty-five Wistar rats (15 males and 10 females) were utilized, housed in well-ventilated cages at a 3:2 female-to-male ratio Monosodium glutamate was induced in pups using intraperitoneal monosodium glutamate injections from postnatal days 2 through 10. Normal controls received saline, and all experimental animals were raised on standard rat chow until reaching a weight of ≥150g. The study encompassed five groups, each consisting of 7 animals. Groups IV, V, and VI were treated with Tetracarpidium conophorum nut extracts: ethanol whole extract (EWE), ethyl acetate extract (EAE), and ethanol residue (ER), respectively. Group III, the standard control was given 5.14g/kg of Orlistat reconstituted in normal saline. Experimental animals of groups I and II served as the normal and obese controls, respectively. After a six-week treatment period, the animals were euthanized for organ harvesting. Results indicated varying weight changes among treatment groups compared to controls. The EWE-treated group displayed a notable decrease in weight (-1.40 ± 8.42) compared to the obese control (8.29 ± 8.29). Similarly, EAE-treated animals exhibited weight reduction (-6.90 ± 12.29), as did the ER-treated group (-0.10 ± 12.22). Evidently, EWE treatment induced the most substantial weight loss. Tetracarpidium conophorum nut extracts demonstrated potential in alleviating obesity-related weight gain in the rat model.

14

Metaboliczna otyłość z prawidłową masą ciała i otyłość z prawidłowymi wskaźnikami metabolicznymi a ryzyko metaboliczno-naczyniowe

88%

Nowak M. , Grzywa M.

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nr 3

270-278

PL

Otyłość jest czynnikiem ryzyka śmiertelności ogólnej, zgonów z przyczyn sercowo-naczyniowych i nowotworowych . Jest uznanym, niezależnym czynnikiem rozwoju miażdżycy naczyń. Ryzyko wystąpienia chorób somatycznych zwią- zanych z otyłością zależy nie tylko od stopnia otyłości, ale głównie od rozmieszczenia tkanki tłuszczowej. Kluczową rolę w rozwoju insulinooporności, nietolerancji glukozy, cukrzycy typu 2, nadciśnienia tętniczego oraz chorób układu sercowo naczyniowego odgrywa trzewna tkanka tłuszczowa. Przeprowadzone badania wskazały, że osoby otyłe nie są grupą jednorodną pod względem profiu metabolicznego, a BMI nie jest uniwersalnym wskaźnikiem otyłości. W latach 80. XX wieku Ruderman wyróżnił tzw. metaboliczną otyłość z prawidłową masą ciała, w której zwiększona ilość tkanki tłuszczowej trzewnej i podskórnej brzucha związana jest ze zwiększonym ryzykiem zaburzeń metabolicznych. Insulinooporność i hiperinsulinemia uznawane są za kluczowe zaburzenia w tej grupie osób. Wraz ze współistniejącymi zaburzeniami gospodarki węglowodanowej, lipidowej i podwyższonym ciśnieniem tętniczym wskazują na podwyższone ryzyko schorzeń układu sercowo-naczyniowego. Z kolei w populacji osób otyłych wyróżniono podgrupę osób metabolicznie zdrowych, u których akumulacja tkanki tłuszczowej nie prowadzi do rozwoju insulinooporności, zaburzeń gospodarki węglowodanowej i lipidowej oraz nadciśnienia tętniczego. Kilka z przeprowadzonych badań wskazało, że u osób otyłych prawidłowe wskaźniki metaboliczne mogą istotnie zmniejszać ryzyko chorobowe. Jednak w świetle obecnego stanu wiedzy otyłość z prawidłowymi wskaźnikami metabolicznymi nie jest w pełni bezpieczna.

EN

The obesity is a risk factor for cardiovascular, cancer and general mortality. It is also an independent risk factor for atherosclerosis. The incidence of obesity-related diseases depends not only on the degree of obesity but mainly on the fat tissue deposition. It is the visceral fat tissue that plays the major role in the development of insulin resistance, impaired glucose tolerance, diabetes, hypertension and cardiovascular diseases. The research showed that the population of obese people is not homogenous in terms of metabolic profie and that a BMI is not the universal obesity indicator. In the 80s Ruderman distinguished metabolic obesity with normal weight. It is defied as an increased amount of visceral and subcutaneous abdominal fat and is associated with an increased risk of metabolic disorders. Insulin resistance and hyperinsulinemia are considered to be the fundamental disorders in this group. The coexistence of impaired carbohydrate and lipid metabolism and hypertension leads to a high risk of cardiovascular disease. The fat tissue deposition enabled also to identify the obese patients that are not at risk of insulin resistance, glucose or lipid metabolism disorders and hypertension (“metabolically healthy”). There are some studies that show the reduction of cardiovascular risk among obese patients with normal metabolic parameters. However, the current knowledge does not allow us to regard obesity with normal metabolic parameters as completely safe.

15

The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss

88%

Jankiewicz-Wika J. , Kołomecki K. , Cywiński J. , Piestrzeniewicz K. , Stępień H. , Komorowski J.

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nr 2

136-147

EN

Bariatric surgery is the most effective method to achieve weight loss in obese subjects. The aim of this study was to evaluate some adipocytokines and insulin, as well as parameters of metabolic syndrome of the obese patients, for three and six months after vertical banded gastroplasty, in the time of dynamic weight loss. Seven males and two females aged 28 to 49 years, with long lasting simple obesity and the presence of metabolic syndrome, were studied. After surgical treatment the values of the body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, triglycerides, and blood concentrations of leptin decreased significantly. Before surgical operation of all obese patients no statistically significant correlations between studied parameters were noted. Three and six months later a lot of correlations between studied parameters appeared. In conclusion, (a) vertical-banded gastroplasty is a valuable method in treatment of obese subjects, leading to a significant decrease in body weight and improvement in some parameters of metabolic syndrome in a few months after surgery, (b) adipocytokines, together with an unknown gastric factor, may be key factors in the control of some features of the metabolic syndrome.

16

Research on obesity – time to think about the next agendas

75%

Touray M.

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nr 2

40-52

EN

Purpose: The purpose of this paper is to highlight a fundamental gap in the economic research on obesity - the demand for unnecessary weight gain preventive goods. Such research is important as it will provide understanding of people’s preventive behaviours and for that matter inform policies and practices with regards to influencing people’s uptake of obesity preventive goods. Materials and methods: Using MeSH and PICO approaches, a search strategy was developed to search for relevant articles in a number of academic and scientific journal repositories including PubMed Central, EconLit, Medline, Medscape and relevant (economic) journals’ archives. The search strategy combined terms/phrases to look for publications. Results: A total of 1351 potentially relevant articles (titles and abstracts) were reviewed. No publications could be found that concerned people’s preventive behaviours in terms of demand with respect to obesity preventive goods. Only one article which was not specific to obesity looked into people’s preventive behaviours using an economic model. Conclusions: Despite the huge economic and health burden of obesity, participations in activities deemed supportive to weight gain prevention are dismal. It must not therefore be assumed that there will be demand for all effective weight preventive goods/services. As a result of the complex nature of the condition, the demand for obesity preventive goods requires understanding of the complex factors which influence individual decisions. The behavioural economic perspective could help to increase understanding of the preferences of people as it examines how decisions are made by individuals in complex socio-economic and socio-cultural circumstances and financial constraints involving trade-offs.

17

The changes in running economy during puberty in overweight and normal weight boys

75%

Maciejczyk M. , Gradek J. , Szymura J. , Cempla J. , Więcek M. , Tota Ł.

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nr 1

EN

Study aim: running economy (RE) is important indicator of endurance performance. During puberty dynamic changes in body composition and function are observed, as such RE is also expected to change. The aim of the study was to compare the running economy (RE) in overweight and normoweight boys during a running exercise performed with constant velocity, and the assessment of changes in RE during puberty. Material and methods: the RE of the subjects was evaluated twice: at the age of 11–12 and two years later. 18 overweight and 17 normal weight boys performed a graded test and a week later a submaximal run on a mechanical treadmill. During the exercise, physiological variables (oxygen uptake, heart rate, pulmonary ventilation, tidal volume and breathing frequency) were measured. Results: the intensity of work in both tests (%VO2max, %HRmax) was significantly higher in the overweight boys and decreased with age (non significantly) in both groups. The physiological response during the run in the overweight boys was significantly higher compared to normal weight. When the oxygen uptake was expressed as VO2.BM–0.75, the RE was similar in normal weight and overweight boys. During puberty, the inter-group differences in the metabolic cost of work stay at a relatively stable level. Conclusions: the lowered endurance performance in the overweight boys during puberty remains unchanged. The changes in physiological variables during puberty in both groups occurred in a similar way – the body composition did not influence the course of these changes in puberty.

18

Impact of ER gene polymorphisms on overweight and obesity in Down Syndrome

75%

Ferrara M. , Capozzi L. , Russo R.

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nr 3

271-278

EN

The impact of ER XbaI and PvuII α gene polymorphisms on overweight and obesity were studied in 77 subjects with Down Syndrome (DS), of which 32 were children (18 boys, 14 girls), mean age 8.7 ± 2.3 years, and 45 adolescents (28 boys, 17 girls) mean age 14 ± 2.5 years. Their lifestyle was compared to 40 healthy age-matched controls. DS subjects had significant lesser physical activity than controls (p<0.05) and a lower caloric intake than the recommended requirements, which was significantly lesser than controls (p<0.05). Body Mass Index (BMI), Arm Circumference (AC) and Triceps Skinfold Thickness (TST) were significantly higher in DS subjects than controls (p<0.05), while metabolic and cardiovascular parameters were not significantly different between the groups (p>0.05). The frequency of ER genotypes in DS subjects was compared with the healthy controls, finding that there was a high prevalence of XXER genotype in DS subjects. Children and adolescents with DS, lacking ER XbaI site, showed significantly higher BMI and body fat distribution than other XbaI genotypes. The lack of ER XbaI site can indicate added risk of obesity in DS. No differences in metabolic and cardiovascular parameters were observed among ER genotypes. However, childhood obesity is associated with increased cardiovascular risk.

19

Navigated versus conventional drilling of the knee in a model of obesity

75%

Beckmann J. , Tingart M. , Goetz J. , Anders S. , Grifka J. , Kock F.

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nr 1

89-95

EN

Core decompression by exact drilling into ischemic lesions of the femoral condyle stays a challenging procedure, particularly in obese patients. The precision of fluoroscopically-based drilling compared to conventional drilling was evaluated in an in-vitro model for obesity. 40 sawbones were prepared mimicking osteonecrosis in obese patients. 20 sawbones were drilled by guidance of an intraoperative navigation system VectorVision® (BrainLAB, Munich, Germany); the other 20 sawbones were conventionally drilled by fluoroscopic control only. Regarding the distance to the desired mid-point of the lesion, a statistically significant difference with 0.55 mm in the navigated group and 1.19 mm in the control group could be stated (p<0.001). Significant differences were further found for the number of drilling corrections (p<0.001) and radiation time needed (p<0.001). Even in difficult circumstances as in obese patients, the drilling guided by the VectorVision®-navigation system shows high precision with simultaneous enormous reduction of radiation time.