Wyniki wyszukiwania - Biblioteka Nauki

1

Etiopathogenesis of allergic diseases

100%

Kanikowska A. , Napiorkowska-Baran K. , Graczyk M. , Kucharski M. , Zietkiewicz M.

Health Problems of Civilization

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2018

|

tom 12

|

nr 3

EN

Allergic diseases are the most common chronic diseases, particularly widely spread among children, adolescents and young adults. The problem is that there is an increasing incidence of allergic diseases. The causes of such a sudden increase of incidence rate are not well known. Complex interactions of environmental factors seem to play their role in the phenomenon. These include: change in the dietary and hygienic habits, progressing industrialization and increased use of numerous chemical agents. It was shown that inhabitants of highly industrialised nations, as compared to those from the developing countries, suffer from allergic diseases more frequently (most often in USA, Australia, Great Britain, Ireland and New Zealand, least frequently in Eastern Europe, Russia, China, India and Ethiopia), inhabitants of cities rather than those of rural areas, children who have no siblings rather than those from large families [1]. Knowledge of the factors that cause or influence the course of allergy is significant as it can help prevent and properly treat this disorder. It seems especially vital as in some patients allergy can manifest itself in the form of severe anaphylactic reactions, including an anaphylactic shock burdened with high risk of death.

PL

Choroby alergiczne są jednymi z najczęściej występujących schorzeń przewlekłych, szczególnie rozpowszechnione wśród dzieci, młodzieży i młodych dorosłych. Problem stanowi fakt, że częstość występowania tych chorób stale wzrasta. Przyczyny tak gwałtownego wzrostu zachorowań nie są do końca poznane. Podkreślana jest rola złożonych interakcji czynników środowiskowych takich jak: zmiana nawyków żywieniowych i higienicznych, postępujące uprzemysłowienie i wzrost stosowania wszelakich środków chemicznych. Wykazano, że na schorzenia alergiczne częściej chorują mieszkańcy krajów wysoko uprzemysłowionych niż krajów rozwijających się (najczęściej w USA, Australii, Wielkiej Brytanii, Irlandii i Nowej Zelandii, najrzadziej w Europie Wschodniej, Rosji, Chinach i Indiach i Etiopii), mieszkańcy miast niż wsi, dzieci nieposiadające rodzeństwa niż dzieci z licznych rodzin [1]. Znajomość czynników, które wywołują lub wpływają na przebieg alergii jest bardzo ważna, aby móc zapobiegać i odpowiednio leczyć te schorzenia . Tym bardziej, że u części pacjentów alergia może objawiać się ciężkimi reakcjami anafilaktycznymi, w tym wstrząsem anafilaktycznym obarczonym wysokim ryzykiem zgonu.

2

Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

100%

Galecka M. , Szachta P. , Bartnicka A. , Lykowska-Szuber L. , Eder P. , Schwiertz A.

Polish Journal of Microbiology

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2013

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tom 62

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nr 1

EN

The aim of the study was evaluation of the correlation between the level of clinical activity of Crohn’s disease (CD) and the number of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA) in stool. 34 individuals diagnosed with Crohn’s disease participated in this study in 2011. The disease activity was determined according to the Crohn Disease Activity Index (CDAI). The number of Faecalibacterium prausnitzii and total number of bacteria were monitored by RT-PCR. The concentrations of SCFA were determined by gas chromatography. In CD patients, Faecalibacterium prausnitzii number and percentage of the total number of bacteria were greatly reduced. In patients with CD the percentage of acetate was elevated (70%), while the percentages of propionate and butyrate were significantly reduced (14.9% and 7.99%, respectively).

3

Pathophysiology of portal hypertension

100%

Cichoz-Lach H. , Celinski K. , Slomka M. , Kasztelan-Szczerbinska B.

Journal of Physiology and Pharmacology. Supplement

|

2008

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tom 59

|

nr 2

EN

In last years significant progress in recognizing mechanisms of portal hypertension pathophysiology was done. However, some unclear topics in this disease still exist. Portal hypertension is primarily caused by the increase in resistance to portal outflow and secondly by an increase in splanchnic blood flow. Portal hypertension is associated with changes in the intrahepatic, systemic, and portosystemic collateral circulation. Alterations in vasoreactivity (vasodilation and vasoconstriction) play a central role in the pathophysiology of portal hypertension by contributing to increased intrahepatic resistance, hyperdynamic circulation, and expansion of the collateral circulation. Among vasoactive substances which are activated in portal hypertension nitric oxide (NO) is considered as the most important vasodilator. Endothelin-1 and cyclooxygenase-derived prostaglandins are the main vasoconstrictor factors. The imbalance between the hyperresponsiveness and overproduction of vasoconstrictors and the hyporesponsiveness and impaired production of vasodilators are the mechanisms responsible of the increased vascular tone in the sinusoidal area of the liver. New concepts in the pathophysiology of portal hypertension find the significant role of hepatic stellate cells activated by endothelial factors which cause vascular remodeling as an adaptive response of the portal vessels wall. The most frequent causes of portal hypertension include portal vein thrombosis, storage diseases of the liver, hepatic cirrhosis (independent of etiology), hepatic veins thrombosis and schistosomiasis. Understanding the pathophysiology of portal hypertension could be of great utility in preventing and curing the complications of portal hypertension, such as esophageal varices, hepatic encephalopathy, ascites.

4

The protective role of the HLA-DR locus in patients with various clinical types of alopecia areata

86%

Broniarczyk-Dyla G. , Prusinska-Bratos M. , Dubla-Berner M. , Arkuszewska C. , Borowiec M. , Kowalski M. L. , Woszczek G.

Archivum Immunologiae et Therapiae Experimentalis

|

2002

|

tom 50

|

nr 5

5

The detection of Helicobacter pylori in paraffin sections using the PCR technique and various primers as compared to histological techniques

86%

Ciesielska U. , Dziegiel P. , Jagoda E. , Podhorska-Okolow M. , Zabel M.

Folia Morphologica

|

2004

|

tom 63

|

nr 2

EN

Helicobacter pylori is thought to represent a significant etiopathogenic factor in diseases of the upper gastrointestinal tract. It seems, therefore, important to elaborate effective techniques for its detection. The aim of the present study was to evaluate the effectiveness of Helicobacter pylori detection using the PCR technique on paraffin sections with various pairs of primers and to compare the results with those of a histological appraisal. Material for the studies involved 50 paraffin blocks with gastric mucosa biopsies fixed in 4% buffered formalin. In this material 4 tests were performed with the aim of diagnosing Helicobacter pylori infection: 1) H+E staining, 2) staining by the Giemsa technique, 3) an immunocytochemical technique with antibodies against H. pylori and 4) the PCR technique with various primers. In the present study the most reliable results for H. pylori detection as well as the most pronounced correlation were obtained by using the PCR technique with primers for the ureC gene, immunohistochemistry and staining according to Giemsa. Less compatible results were obtained employing the two PCR techniques which utilise various primers. The experiments confirmed the usefulness of the PCR technique in the detection of Helicobacter pylori in paraffin sections by using a suitable pair of primers, and also indicated that Giemsa staining and immunohistochemistry should be taken into account.

6

Increasing incidence of diabetes mellitus type 1 in children - the role of environmental factors

86%

Mysliwiec M. , Balcerska A. , Zorena K. , Jedrzejczyk A. , Malinowska E. , Mysliwska J.

Polish Journal of Environmental Studies

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2007

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tom 16

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nr 1

EN

The incidence of diabetes type 1, a chronic autoimmune disease, may reach the status of an epidemic in the 21st century. The highest incidence of diabetes in the world is observed in Finland. However, in the last 8 years a dynamic rise has been observed in Poland, moving the country toward an intermediate level incidence classification. Environmental factors seem to play a part in the observed increase in diabetes incidence both in Poland and in the world since, by acting on genetically predisposed ground prompt to auto-aggression, they may provoke disease occurrence. The study was carried out on a group of 511 children aged 0-15 years (255 girls and 256 boys). During the period of analysis (1998-2005) almost a two-fold increase in the diabetes incidence rate was observed (1998-10.4 vs 2005-20.4). The identification of all the factors increasing the risk of diabetes mellitus type 1 shall allow for understanding of diabetes ethiopathogenesis, and thus might create a chance for development of new prevention strategies.

7

Psoriasis vulgaris with the early and late onset - HLA phenotype correlations

86%

Szczerkowska-Dobosz A. , Placek W. , Szczerkowska Z. , Roszkiewicz J.

Archivum Immunologiae et Therapiae Experimentalis

|

1996

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tom 44

|

nr 4

8

Emerging concepts in the molecular pathogenesis of systemic lupus erythematosus

86%

Nambiar M. P. , Juang Y. T. , Tsokos G. C.

Archivum Immunologiae et Therapiae Experimentalis

|

2002

|

tom 50

|

nr 1

9

Vitamin D and its relevance in the etiopathogenesis of oral cavity diseases

72%

Slebioda Z. , Szponar E. , Dorocka-Bobkowska B.

Archivum Immunologiae et Therapiae Experimentalis

|

2016

|

tom 64

|

nr 5

10

Cytokine-mediated cross-talk between glia and neurons: neuropathological implications for epilepsy

72%

Vezzani A. , Balosso S. , Maroso M. , Rizzi M. , Noe F. , Zardoni D. , Frasca A. , Ravizza T.

Acta Neurobiologiae Experimentalis

|

2009

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tom 69

|

nr 3

EN

Recent fi ndings in experimental models and in the clinical setting highlight the possibility that infl ammatory processes in the brain contribute to the etiopathogenesis of seizures and to the establishment of a chronic epileptic focus. Prototypical infl ammatory cytokines such as IL-1β and TNF-α are overexpressed in epileptogenic brain areas, prominently by glia and to a lesser extent by neurons and endothelial cells of the blood brain barrier. Cytokine receptors are also upregulated, and the related intracellular signalling is activated, highlighting both autocrine and paracrine actions of cytokines in diseased brain. Cytokines can profoundly affect neuronal network excitability, and the recent demonstration of molecular and functional interactions between cytokines and classical neurotransmitters, such as glutamate and GABA, provides one mechanism by which cytokines affect neuronal activity. These interactions may result in increased tissue excitability leading to seizures and cell loss. These fi ndings describe novel communications between glia and neurons which may contribute to pathological conditions (e.g. seizures, neurodegeneration) characterized by the activation of infl ammatory processes, thus highlighting potential new targets for therapeutic intervention.

11

Etiopatogeneza nadciśnienia tętniczego u kobiet ciężarnych

72%

Maksym M. , Madej P. , Lemm M. A.

Annales Academiae Medicae Silesiensis

|

2015

|

tom 69

69-75

EN

Hypertension during pregnancy is one of the most severe complications of pregnancy and can cause materno-foetal morbidity and mortality. Research on preventing pregnancy-induced hypertension, preeclampsia and eclampsia has been gaining interest in recent years. However, due to the unknown etiology of these diseases, their prevention is currently not possible. The aim of this article is to explore current data on the etiopathogenesis of the aforemen-tioned afflictions, as well as on the possibilities for their early diagnosis in pregnant women.

PL

Nadciśnienie tętnicze w przebiegu ciąży jest jednym z najpoważniejszych powikłań ciąży i może stanowić zagrożenie dla życia ciężarnej oraz jej dziecka. W ostatnich latach coraz szerszym zainteresowaniem cieszą się badania nad profilaktyką nadciśnienia indukowanego ciążą, stanu przedrzucawkowego i rzucawki. Jednakże ze względu na nieznaną etiologię tych schorzeń pierwotna profilaktyka nie jest obecnie możliwa. W niniejszej pracy starano się przybliżyć stan wiedzy na temat etiopatogenezy oraz możliwości wczesnego wykrywania ciężarnych zagrożonych występowaniem tych zaburzeń.

12

Changes in the lymphatic vessels network of the larynx caused by atrophy and hypertrophy of mucosa

72%

Skarzynski H. , Skarzynska B. , Kukwa A. , Nowak M.

Folia Morphologica

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1988

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tom 47

|

nr 1-4

13

Entezopatie i zapalenie entez. Część I. Etiopatogeneza

72%

Sudoł-Szopińska I. , Kwiatkowska B. , Prochorec-Sobieszek M. , Maśliński W.

Journal of Ultrasonography

|

2015

|

tom 15

|

nr 60

72-84

EN

The pathologies of tendon and ligament attachments are called enthesopathies. One of its types is enthesitis which is a characteristic sign of peripheral spondyloarthropathy. Clinical diagnosis of enthesitis is based on rather non-specific clinical signs and results of laboratory tests. Imaging examinations are highly promising. Numerous publications prove that enthesitis can be differentiated from other enthesopathic processes in an ultrasound examination or magnetic resonance imaging. However, some reports indicate the lack of histological criteria, specific immunological changes and features in imaging examinations that would allow the clinical diagnosis of enthesitis to be confirmed. The first part of the publication presents theories on the etiopathogenesis of enthesopathies: inflammatory, mechanical, autoimmune, genetic and associated with the synovio-entheseal complex, as well as theories on the formation of enthesophytes: inflammatory, molecular and mechanical. The second part of the paper is a review of the state-of-the-art on the ability of imaging examinations to diagnose enthesitis. It indicates that none of the criteria of inflammation used in imaging medicine is specific for this pathology. As enthesitis may be the only symptom of early spondyloarthropathy (particularly in patients with absent HLA-B27 receptor), the lack of its unambiguous picture in ultrasound and magnetic resonance scans prompts the search for other signs characteristic of this disease and more specific markers in imaging in order to establish diagnosis as early as possible.

PL

Patologie przyczepów ścięgien i więzadeł są określane mianem entezopatii. Jednym z rodzajów entezopatii jest zapalenie (enthesitis), które stanowi charakterystyczny objaw spondyloartropatii obwodowych. Enthesitis jest rozpoznawane przez klinicystów na podstawie mało specyficznych objawów klinicznych i wyników badań laboratoryjnych. Duże nadzieje wiązane są z badaniami obrazowymi. Wiele prac naukowych dowodzi możliwości różnicowania zapalenia entez z innymi procesami entezopatycznymi w badaniach ultrasonograficznych albo metodą rezonansu magnetycznego. W sprzeczności pozostają doniesienia wskazujące na brak kryteriów histologicznych, specyficznych zmian immunologicznych oraz cech w badaniach obrazowych pozwalających na potwierdzenie klinicznego rozpoznania zapalenia. W pierwszej części publikacji przedstawiono teorie etiopatogenezy entezopatii: zapalną, mechaniczną, kompleksu entezy, autoimmunologiczną i genetyczną oraz koncepcje powstawania entezofitów: zapalną, molekularną i mechaniczną. Druga część pracy stanowi przegląd aktualnej wiedzy na temat możliwości badań obrazowych w rozpoznawaniu enthesitis. Wskazuje on, że żadne ze stosowanych w badaniach obrazowych kryteriów zapalenia nie jest specyficzne dla tej patologii. Ze względu na fakt, że może być ono jedynym objawem spondyloartropatii w początkowym ich okresie (zwłaszcza u chorych z nieobecnym antygenem HLA-B27), brak jednoznacznego obrazu enthesitis w badaniach ultrasonograficznych i rezonansu magnetycznego wymaga poszukiwania innych objawów charakterystycznych dla tych chorób oraz bardziej specyficznych markerów w badaniach obrazowych w celu jak najszybszego ustalenia rozpoznania.

14

Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review

72%

Slebioda Z. , Szponar E. , Kowalska A.

Archivum Immunologiae et Therapiae Experimentalis

|

2014

|

tom 62

|

nr 3

15

Prevalence of fungi in cases of geographical and fissured tongue

72%

Dudko A. , Kurnatowska A. J. , Kurnatowski P.

Annals of Parasitology

|

2013

|

tom 59

|

nr 3

16

Etiopatogeneza i profilaktyka zakaźnego zanikowego zapalenia nosa świń w świetle najnowszych badań

72%

Szweda W.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

|

1988

|

tom 18

17

Toxic-shock syndrome with special regard to clinical aspects in animals. Selected problems

72%

Furowicz A. J. , Borkowski J. , Ferlas M.

Advances in Agricultural Sciences

|

2004

|

tom 09

18

Pathophysiology and pharmacology of systemic lupus erythematosus

72%

Schneider M.

Journal of Physiology and Pharmacology

|

1993

|

tom 44

|

nr 3

19

Evaluation of interleukin-1 and -6 in the etiopathogenesis of idiopathic osteoporosis and osteopenia in children

72%

Rusinska A. , Chlebna-Sokol D.

Archivum Immunologiae et Therapiae Experimentalis

|

2005

|

tom 53

|

nr 3

20

The value of magnetic resonance imaging in diagnosis and monitoring of treatment in multiple sclerosis

72%

Bekiesinska-Figatowska M. , Walecki J. , Stelmasiak Z.

Acta Neurobiologiae Experimentalis

|

1996

|

tom 56

|

nr 1