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Thioamides, especially thiobenzanilidies and related compounds, are characterized by a wide spectrum of biological activities (antimicrobial, anthelmintic, analgesic, anti-inflammatory) depending on the type of substitution. 2.4-dihydroxythiobenzanilides have been discovered to have interesting in vitro efficiency against dermatophytes, yeasts and moulds. The purpose of this study was to assess adverse reactions of thioamides after skin contact. The study was done on 29 guinea pigs. The guinea pig maximization test (acc. Magnusson Kligman test) was used to estimate the risk of the skin contact allergic reactions. Skin irritation of the examined substances in different concentrations was assessed after epidermal topical application. Cross- -reactions between thioamides and tetramethylthiuram disulfide was also examined. The leukocyte inhibition migration test (in vitro test) was done to confirm results of skin epidermal tests. Thioamides derivatives have very weak irritant properties and using these compounds in therapeutic concentrations (0.5-3%) has no risk of irritant adverse reaction after coming into contact with skin. Cross-reactivity was noticed among 2.4-dihydroksytiobenzamid and tetramethylthiuram disulfide. 2.4-dihydroksytiobenzamid is characterized by a weak sensitizing capacity (only 20% of animals were sensitized in GPMT) and according to OECD guidelines it may not be classified as a skin sensitizer (R43), but in special circumstances it may cause allergic contact dermatitis.
The objective of the studies was to determine the extensiveness and intensity of mallophagian lice invasion in guinea pigs in different laboratory animal husbandries and control of the invasion with preparates used to eliminate ectoparasites in domestic animals. A total of 1550 guinea pigs from 4 husbandries have been examined. In three husbandries all the animals were infested by mallophagian lice. The most prevalent appeared to be Gliricola porcelli (100%) then Gyropus ovalis (90%) and the less prevalent Trimenopon hispidum (40%). The intensity of invasion with individual species of mallophagian lice was similar because G. porcelli infected guinea pigs in a greater number — a mean number 456 parasites/animal, C. ovalis — 32 and T. hispidum — 37. Biocid 0.1%, Insectin 0.5%, Ivomec 200 µg and 400 µg and Pularyl applied according to the prescriptions of producers appeared to be very effective in the control of mallophagian infection excep of Pularyl in spray which was completely ineffective. Biocid 0.1% and Insectin 0.5% in spray used twice at 2 week interval enabled a total eradication of mallophagian lice invasion in guinea pig husbandries.
3-hydroxy-3-methylbutyric acid (HMB) in immunological reactions generated by nutritional allergy in guinea pigs The systemic immune responses were examined in pa- renterally milk-sensitized guinea pigs. This type of sensitization simulating alimentary allergy led to positive passive cutaneous anaphylactic (PCA) responses and high IgG titers against beta lactoglobulin (beta-LG). A further increase in IgG titers induced by a dietary supplement of HMB was observed. These results indicate that HMB increases immune responses of parenterally milk-sensitized guinea pigs as expressed by IgG beta-LG antibodies and PCA titers. What concerns the alimentary, this effects is not of an advantage and suggests that HMB - treated animals can be more allergic to food consumption.
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