Wyniki wyszukiwania - Biblioteka Nauki

1

Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor.

100%

Funa K. , Uramoto H.

Acta Biochimica Polonica

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2003

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tom 50

|

nr 3

647-658

EN

PDGF is one of the most potent serum mitogens, and the signalling mechanism by way of its receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in various tumours and stroma led to the proposal of the PDGF-mediated autocrine and paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival of cells, the expression and activity of PDGF receptors are tightly controlled by both positive and negative feedback mechanisms at different levels. The deregulation of the control system can result in serious pathological conditions such as chronic inflammation and tumours. Understanding the molecular mechanisms for the regulatory system and the signalling pathway of PDGF is essential in order to find effective therapies in the diseases where PDGF is involved.

2

Influence of nonselective ETA-ETB receptor blockade on renal function in conscious rats: effects of renal denervation

100%

Girchev R. , Markova P. , Vuchidolova V.

Journal of Physiology and Pharmacology

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2004

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tom 55

|

nr 2

EN

The effects of nonselective ETA/ETB receptor blockade with intravenous bolus injection of bosentan (10 mg/kg) on renal excretory function and blood pressure were investigated in conscious, male, normotensive Wistar rats before and one week after bilateral renal denervation. Renal denervation was followed by an increase in urine flow rate from 4.54±0.38 to 5.72±0.36 µl/min.100 g b.w. (p<0.05) and a decrease in urine osmolality from 855.5±44.6 to 707.4±47.5 mosm/kg H2O (p<0.05). Bosentan administration in sham-operated rats resulted in decrease in urine flow rate from 4.54±0.38 to 3.49±0.34 µl/min.100 g b.w. (p<0.05), and increase in urine osmolality from 855.5±44.6 to 1075.0±76.1 mosm/kg H2O (p<0.05). Sodium excretion decreased from 226.9±20.0 to 155.1±11.0 nmol/min.100 g b.w. (p<0.01). Bosentan administration in renal denervated rats did not produce any changes in renal water or electrolyte excretions. Blood pressure, heart rate, clearance of Inulin or clearance of paraaminohippuric acid (PAH) did not change in sham-operated or renal denervated rats during nonselective ETA/ETB receptor blockade. Bosentan did not alter the baroreflex sensitivity or sympatho-vagal balance in sham-operated or renal denervated rats. In conclusion, an interaction between renal nerves and endothelins appears to be involved in the regulation of the renal excretory function.

3

Specific, irreversible inhibitors of the epidermal growth factor receptor [EGFR] family of tyrosine kinases

100%

Fry D. W.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

4

Expression of vascular endothelial growth factor [VEGF] and its receptor FLK-1 in non-small cell lung cancer [NSCLC] - a preliminary report

100%

Dziadziuszko R. , Chyczewski L. , Jassem E. , Jassem J.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

|

nr 1

5

Receptor for ferrioxamine B in Staphylococcus aureus B 47 strain

100%

Wysocki P. , Lisiecki P. , Mikucki J.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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2003

|

tom 51

|

nr 4

6

Basic fibroblast growth factor and its receptors in human embryonic stem cells

100%

Dvorak P. , Hampl A.

Folia Histochemica et Cytobiologica

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2005

|

tom 43

|

nr 4

7

Assessment of endocrine disruptors: approaches, issues, and uncertainties

100%

Chen C. W.

Folia Histochemica et Cytobiologica. Supplement

|

2001

|

tom 39

|

nr 1

8

Opakowania żywności do ogrzewania w kuchenkach mikrofalowych

86%

Przetaczek-Rożnowska I.

Przemysł Spożywczy

|

2010

|

tom T. 64, nr 1

40-43

PL

Konsumenci wykorzystują kuchenki mikrofalowe do szybkiego rozmrażania, podgrzewania oraz pieczenia i gotowania posiłków. Dlatego istotny jest dobór odpowiedniego opakowania, aby podczas podgrzewania żywności w opakowaniu w polu mikrofalowym nie uległo ono deformacji, nie roztopiło się, a także nie wpłynęło w żaden sposób na jakość i bezpieczeństwo żywności. Przed doborem opakowania producent musi również podjąć decyzję czy produkt podczas ogrzewania w kuchence mikrofalowej ma uzyskać chrupiącą skórkę, brązowe zabarwienie czy może opakowanie ma być pomocne w ograniczeniu miejscowych przypaleń. Aby dobrać odpowiednie opakowanie, należy znać właściwości materiału, z którego jest wykonane opakowanie.

EN

Consumers use microwave ovens for thawing out a meal, warming up a lunch, cooking a cake and boiling. Therefore the package cannot be deformated during microwave irradiation and also it should not melt, distort or be otherwise affected by the hot food. Manufacturers ought to decide whether the packaging materials should permit formation of crisp crusts or a foil shielding should prevent meal from local overheating. Before making decision, the manufacturers should have sufficient knowledge about properties of packaging materials.

9

Dual representation of samples for negative selection issues

86%

Chmielewski A. , Wierzchoń S. T.

Computer Assisted Mechanics and Engineering Sciences

|

2007

|

tom Vol. 14, No. 4

579-590

EN

This paper presents a new dual model combining binary and real-valued representations of samples for negative selection algorithms. Recent research show that the two types of encoding can produce quite good results for some types of datasets when they are applied separately in such algorithms. Besides a number of efficient algorithms, various affinity (or similarity) functions fitted to particular implementation was investigated. Basing on a series of experiments, we propose a dual representation enabling overcome some of the existing drawbacks of these algorithms, and allowing significant speed up the classification process. This new model was designed mainly for detecting anomalies in real-time applications, were the time of classification is crucial, e.g. intrusion detection systems.

10

Analysis of T cell receptor alpha beta variability in tumor-infiltrating lymphocytes in primary and metastatic melanoma

86%

Zeuthen J. , Birck A. , Straten P. T.

Archivum Immunologiae et Therapiae Experimentalis

|

1995

|

tom 43

|

nr 2

11

Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor

86%

Funa K. , Uramoto H.

Acta Biochimica Polonica

|

2003

|

tom 50

|

nr 3

EN

PDGF is one of the most potent serum mitogens, and the signalling mechanism by way of its receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in various tumours and stroma led to the proposal of the PDGF-mediated autocrine and paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival of cells, the expression and activity of PDGF receptors are tightly controlled by both positive and negative feedback mechanisms at different levels. The deregulation of the control system can result in serious pathological conditions such as chronic inflammation and tumours. Understanding the molecular mechanisms for the regulatory system and the signalling pathway of PDGF is essential in order to find effective therapies in the diseases where PDGF is involved.

12

Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4 lymphocytes

86%

Jagodzinski P. P. , Trzeciak W. H.

Folia Histochemica et Cytobiologica

|

2000

|

tom 38

|

nr 1

13

VEGF, VEGFR-1 and VEGFR-2 immunoreactivity in the porcine arteries of vascular subovarian plexus [VSP] during the estrous cycle

86%

Postek A. , Andronowska A. , Doboszynska T. , Nieweglowski H. , Jankowska K.

Folia Histochemica et Cytobiologica

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2006

|

tom 44

|

nr 1

14

Three-dimensional structures of MHC class I-peptide complexes: implications for peptide recognition

86%

Persson K. , Schneider G.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

|

tom 48

|

nr 3

15

Interleukin 6 and its soluble receptor in periodontitis

86%

Pietruska M. , Pietruski J. K. , Stokowska W. , Jablonska E.

Archivum Immunologiae et Therapiae Experimentalis

|

1998

|

tom 46

|

nr 5

16

Involvement of central and peripheral histamine H3 receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat

86%

Obuchowicz R. , Pawlik M. W. , Brzozowski T. , Konturek S. J. , Pawlik W. W.

Journal of Physiology and Pharmacology

|

2004

|

tom 55

|

nr 1,2

EN

Data concerning cardiovascular effects of peripherally and centrally located histamine H3 receptor stimulation are contradictory, and despite excessive studies their role in the control of the cardiovascular function have not been cleared yet. Effect of histamine H3 receptors activation have been attributed to modulation of sympathetic system activity but exact role of peripherally and centrally located histamine H3 receptors stimulation in the modulation of vascular tone of the mesentery and intestinal metabolism remains unexplored. Aim of the present study was to evaluate the role of centrally and peripherally located histamine H3 receptors in the modulation of vascular tone of the mesentery and metabolic activity of intestinal tissue. In anesthetized rats total mesenteric blood flow (MBF), mucosal intestinal blood flow (LDBF), intestinal oxygen uptake (VO2) and arterial pressure (AP) were determined. Intestinal arterial conductance (C) was also calculated. Administration of the selective histamine H3 receptor agonist imetit (10 µmol/kg i.a) evoked marked changes in hemodynamic and metabolic parameters; MBF, LDBF, C and VO2 were significantly increased, whereas AP was significantly decreased. Pretreatment with histamine H3 receptor antagonist clobenpropit (4 µmol/kg i.a.) abolished imetit-induced circulatory and oxygen uptake responses. Clobenpropit (4 µmol/kg i.a.) alone failed to affect the MBF, LDBF, AP, C and VO2 values. Central administration of imetit (0.1 µmol i.c.v.) markedly increased AP and decreased MBF, LDBF, C and VO2. Pretreatment with histamine H3 receptor antagonist clobenpropit (0,4 µmol i.c.v.) diminished circulatory and metabolic responses to centrally injected imetit. Central histamine H3 receptors blockade by clobenpropit evoked no significant changes in the mesenteric arterial and mucosal microcirculatory blood flow, intestinal metabolism and mean arterial pressure. We conclude that, peripheral histamine H3 receptors when stimulated decreases vasoconstrictory tone of the mesenteric artery and precapillary structures and evokes increase of intestinal oxygen uptake. This might be in part due to inhibition of sympathetic postganglionic fibers vasopressor activity. Central histamine H3 receptor stimulation activates vasoconstrictory sympathetic adrenergic system with possible involvement of other, presumably non-histaminergic receptors system. At basal conditions neither central nor peripheral histamine H3 receptors are involved in the control of mesenteric macro - and microcirculation and intestinal oxygen consumption.

17

Three separate epitopes on human IFN - alpha variants defined by monoclonal antibodies and their role in the binding to receptors

86%

Kandefer-Szerszen M. , Lundgren E.

Archivum Immunologiae et Therapiae Experimentalis

|

1992

|

tom 40

|

nr 3-4

18

Modulation of NMDA receptor-mediated release of [3H]arachidonate in hippocampal slices of immature rats

86%

Salinska E. , Lazarewicz J. W.

Acta Neurobiologiae Experimentalis

|

1995

|

tom 55

|

nr 1

19

Bcl-2 expression in relation to progesterone and estrogen receptors status in endometrial adenocarcinoma in women

86%

Semczuk A. , Miturski R. , Gogacz M. , Tomaszewski J. , Jakowicki J. A.

Cellular and Molecular Biology Letters

|

1997

|

tom 02

|

nr 2

20

Interaction of human erythrocyte glycophorin with immunoglobulins G

86%

Mikulska J. , Gorczyca W. , Lisowski W.

Archivum Immunologiae et Therapiae Experimentalis

|

1996

|

tom 44

|

nr 1