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Peripherally and non-peripherally tetrasubstituted-[(N-methyl-2-pyridylthio)]phthalocyaninato magnesium (II) (5 and 6) and chloro aluminium (III) (7 and 8) tetraiodide have been synthesized and characterized. The photophysical properties of the complexes in dimethyl sulfoxide (DMSO) and aqueous medium in the presence and absence of cremophore EL have been studied. These complexes show high solubility in aqueous medium though they were aggregated. The triplet state quantum yields (FT) and the triplet lifetimes (tT) were found to be higher in DMSO with ΦT ranging from 0.32 to 0.51, while tT ranged from 282 to 622 ms in DMSO, compared to aqueous medium (pH 7.4 buffer) where ΦT ranged from 0.15 to 0.19 and tT from 26 to 35 ms. Addition of cremophore EL in aqueous solution resulted in partial disaggregation and increased photoactivity. The fluorescence lifetimes of the complexes showed strong dependence on their immediate environment. The ionic magnesium(II) and aluminium(III) phthalocyanines strongly bind to bovine serum albumin (BSA).
Photodynamic therapy (PDT) is a novel non-invasive form of light therapy. PDT can be widely applied in various fields of clinical approach, particularly in the treatment of dysplastic conditions and malignant tumours of the brain, gastrointestinal tract, respiratory and reproductive systems. PDT is most frequently utilised in oncological dermatology; however, it could be easily used in the treatment of acne, skin mycosis or viral infections, e.g. HSV infection. The mechanism of PDT is based on the irritation of a chemical, a so-called photosensitizer that was selectively accumulated in a particular pathological tissue, by the light. The outcome of this irritation is a photochemical reaction that transform the photosensitizer into an active toxic substance that destroys the non-functional cells. The advantages of PDT include high efficacy and selectivity, the possibility of multiple administration of light doses and no evident contraindications of simultaneous usage of PDT and other therapeutic methods in patients of various clinical conditions. Moreover, virtually none side effects and excellent cosmetic effects are making PDT a very well tolerated therapy for many patients. Further steps are taken to introduce PDT in the treatments of cardiovascular disorders, e.g. atherosclerosis, eye disorders or photojuvenation of the skin.
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