Wyniki wyszukiwania - Biblioteka Nauki

1

The rare case of metastasis to lumbar part of spinal column from laryngeal cancer

100%

Olejniczak I. , Łukomski M. , Durko T. , Pietruszewska W.

Otolaryngologia Polska

|

2008

|

tom 62(6)

787-790

EN

A rare case of distant metastasis to spinal column – lumbar vertebra (L5) – from laryngeal cancer was reported. It must be noted that in 10 % of cases metastases to vertebral column are fi rst symptom of a neoplastic disease and sixty-fi ve percent of patients with advanced cancer present bone metastases. Metastatic involvement of the bone is one of the most frequent causes of pain in cancer patients and represents one of the fi rst signs of widespread neoplastic disease. Nevertheless metastases to lumbar vertebral column from laryngeal cancer is very rare. In presented case MRI and CT were performed to confi rm metastasis. Laryngological examination revealed tumor of a right part of larynx – squamous cell carcinoma (G2) in histopathological examination. The patient was qualifi ed to palliative radiotherapy and still is under laryngological observation.

2

Clear cell renal carcinoma metastasis in the oral cavity - case report

100%

Milner P. , Janas A. , Grzesiak-Janas G.

Journal of Pre-Clinical and Clinical Research

|

2014

|

tom 08

|

nr 2

EN

Introduction. Metastatic renal cell carcinoma can spread from the primary renal cell carcinoma to other organs, practically to all tissues. Distant metastases – to the tissue of the head and neck – are transferred through the blood and lymph vessels. A case of such a metastasis localized on the palate is relatively rare and therefore poses interesting material for description. Objective. Analysis of a case of cell renal carcinoma meastasis of the palate in a 67-year-old patient, based on clinical observations and medical publications. Conclusion. Clear cell carcinoma metastases to distant organs are often the first sign of a covertly progressing disease of which the primary tumour is localized in the kidney. The treatment is surgical, and prognosis is poor in the case of distant metastases since tumours recur even after a few years.

3

Antiangiogenic gene therapy in inhibition of metastasis.

100%

Szala S. , Szary J. , Cichoń T. , Sochanik A.

Acta Biochimica Polonica

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2002

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tom 49

|

nr 2

313-321

EN

This short review attempts to demonstrate the usefulness of antiangiogenic gene therapy in achieving inhibition of growth in experimentally-induced metastases. Certain normal tissues (for example skeletal muscle) may be used in vivo, after genetic modification, as a "bioreactor", able to produce and secrete into the bloodstream proteins known to exert antiangiogenic effects. By inhibiting neoangiogenesis these proteins would thus prevent the development of metastases. The review discusses also the perspectives of antimetastatic therapy based on certain types of allogenic cells (for example myoblasts and fibroblasts) that had been genetically modified and then microencapsulated. The strategy of encapsulation is aimed at protecting the modified cells secreting antiangiogenic factors from being eliminated by the immune system. Secretion of antiangiogenic proteins by these microencapsulated cells can be controlled with inducible promoters. Antiangiogenic genes remaining under the transcriptional control of such promoters may be switched on and off using antibiotics, such as tetracycline derivatives, or steroid hormones.

4

Paraplegia as a rare presentation of nasopharyngeal carcinoma

100%

Mohamad A. , Devi Susibalan B. , Mohamad I.

Pediatria i Medycyna Rodzinna

|

2018

|

tom 14

|

nr 2

241-244

EN

Nasopharyngeal carcinoma is a common encounter in otorhinolaryngology. It is a non-lymphomatous squamous cell carcinoma that occurs in the epithelial lining of the nasopharynx and shows varying degrees of differentiation. The aetiology is multifactorial. The disease is more common in the Chinese, those exposed to Epstein–Barr virus and in individuals with environmental factors, such as cigarette smoking, consumption of salted fish or preserved vegetables containing volatile nitrosamine, and exposure to industrial fumes or household smoke. Signs and symptoms include neck swelling, hearing loss, nasal blockage, epistaxis, cranial nerve palsy, headache, neck pain, earache or discomfort, weight loss and central nervous system manifestation when distant metastasis is present. Amongst these manifestations, 60% of patients will present with cervical lymphadenopathy followed by epistaxis which occurs in 40% of cases. However, distant site involvement uncommonly becomes the sole presenting symptom. We report a 58-year-old Chinese patient with nasopharyngeal carcinoma who presented with bilateral lower limb weakness. The patient was initially seen by an orthopaedic surgeon, with various radiological investigations conducted, including magnetic resonance imaging. Metastatic lesions were detected at the lumbar vertebra, sacrum and iliac bone. After positron emission tomography, a suspicious primary malignant lesion was detected in the nasopharynx and its biopsy confirmed the diagnosis of nasopharyngeal carcinoma. The patient was referred to the oncology team for definitive treatment, but refused further therapy.

PL

Rak jamy nosowo-gardłowej to często spotykany nowotwór w praktyce lekarza otorynolaryngologa. Jest to nielimfoidalny rak płaskonabłonkowy rozwijający się w warstwie nabłonkowej jamy nosowo-gardłowej i wykazujący różne stopnie zróżnicowania. Etiologia jest wieloczynnikowa. Częściej chorują Chińczycy, a inne czynniki, np. zakażenie wirusem Epsteina–Barr oraz czynniki środowiskowe, takie jak palenie tytoniu, spożywanie peklowanych ryb lub warzyw konserwowych zawierających lotne nitrozoaminy, a także ekspozycja na opary przemysłowe lub pochodzące z gospodarstw domowych, mogą dodatkowo predysponować do rozwoju choroby. Rak nosogardła objawia się obrzękiem szyi, utratą słuchu, niedrożnością nosa, krwawieniem z nosa, porażeniem nerwów czaszkowych, bólem głowy i szyi, bólem lub uczuciem dyskomfortu w uchu i utratą masy ciała, a także dolegliwościami ze strony ośrodkowego układu nerwowego w przypadku przerzutów odległych. Występują powiększone węzły chłonne szyjne (u 60% chorych), a następnie krwawienie z nosa (w 40% przypadków). Niemniej przerzuty odległe rzadko powodują jedyne pierwsze objawy choroby. Przedstawiamy przypadek 58-letniego pacjenta narodowości chińskiej z rakiem jamy nosowo-gardłowej manifestującym się obustronnym osłabieniem kończyn dolnych. Początkowo pacjent zgłosił się do ortopedy, który zlecił różne badania radiologiczne, w tym badanie rezonansem magnetycznym. Zmiany przerzutowe wykryto w obrębie kręgów lędźwiowych, kości krzyżowej i kości biodrowej. Pozytonowa tomografia emisyjna wykazała obecność podejrzanej pierwotnej zmiany złośliwej w jamie nosowo-gardłowej, a biopsja potwierdziła rozpoznanie raka nosogardła. Pacjent został skierowany na oddział onkologiczny celem leczenia radykalnego, lecz odmówił dalszej terapii.

5

S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13

100%

Wang L. , Wang X. , Liang Y. , Diao X. , Chen Q.

Acta Biochimica Polonica

|

2012

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tom 59

|

nr 4

593-598

EN

S100A4 is a member of the S100 family of calcium-binding proteins that is directly involved in tumor metastasis. In the present study, we examined the potential role of S100A4 in metastasis in breast cancer and its relation with matrix metalloproteinase-13 (MMP-13). Analysis of 100 breast cancer specimens including 50 with and 50 without lymph node metastasis showed a significant upregulation of S100A4 and MMP-13 expression in metastatic breast cancer tissues. Positive immunoreactivity for S100A4 was associated with MMP-13 expression. Overexpression of S100A4 in the MDA-MB-231 breast cancer cell line upregulated MMP13 expression leading to increased cell migration and angiogenesis. SiRNA-mediated silencing of S100A4 downregulated MMP13 expression and suppressed cell migration and angiogenesis. Moreover, neutralization of MMP-13 activity with a specific antibody blocked cell migration and angiogenesis in MDA-MB-231/S100A4 cells. In vivo siRNA silencing of S100A4 significantly inhibited lung metastasis in transgenic mice. The present results suggest that the S100A4 gene may control the invasive potential of human breast cancer cells by modulating MMP-13 levels, thus regulating metastasis and angiogenesis in breast tumors. S100A4 could therefore be of value as a biomarker of breast cancer progression and a novel therapeutic target for human breast cancer treatment.

6

Sialyl Lewis a: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells.

88%

Ugorski M. , Laskowska A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 2

303-311

EN

Neoplastic transformation is often associated with characteristic changes in the expression of the sialyl Lewisa and sialyl Lewisx antigens, representing typical tumor-associated carbohydrate antigens. High amounts of sialyl Lewisa are present in human adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate structure is the ligand for E-selectin. Sialylated Lewis structures present on the surface of tumor cells are carried by the carbohydrate chains of glycoproteins and glycolipids. There are several lines of evidence showing that sialyl Lewisa is responsible for the adhesion of human cancer cells to endothelium. E-selectin present on endothelial cells mediates these interactions. Selectins and their carbohydrate ligands can thus play an important role in the selective homing of tumor cells during metastasis. However, the presence of sialyl Lewisa antigen on the surface of tumor cells and their adhesion to E-selectin-expressing cells in in vitro adhesion assay by itself can not be directly related to metastatic properties of all cancer cells.

7

Advances in studies on invasive tumor growth and metastasis

88%

Radzikowski C.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

8

Effect of alpha3beta1 and alphavbeta3 integrin glycosylation on interaction of melanoma cells with vitronectin

75%

Janik M. E. , Przybylo M. , Pochec E. , Pokrywka M. , Litynska A.

Acta Biochimica Polonica

|

2010

|

tom 57

|

nr 1

55-61

EN

The metastatic transformation of melanocytes is associated with altered expression of adhesion molecules, including αvβ3 and α3β1 integrins. Integrin αvβ3 is a primary vitronectin (VN) receptor, while both integrin types take part in adhesion to VN when they are in complex with uPAR. Although their role in melanoma cell interaction with VN is of great interest, the influence of N-oligosaccharides attached to these glycoproteins is still unappreciated. The present study assesses the role of αvβ3 and α3β1 integrins and the influence of their glycosylation status on WM9 and WM239 metastatic melanoma cell interactions with VN. Cell adhesion to and migration on VN were selected as the studied cell behaviour parameters. Functionblocking antibodies and swainsonine (SW) treatment were used in these tests. Both cell lines interacted with VN in an integrin-mediated but cell-line-specific manner. In WM9 cells, migration was not completely inhibited by antibodies against α3β1 or αvβ3 integrins, suggesting the participation of other VN receptors. In both cell lines in coprecipitation test the formation of an integrins/uPAR complex was shown. In the presence of SW formation of the complex did not occur, suggesting the participation of glycosylation in this proccess. Additionally, the adhesion properties of WM9 cells were changed after SW treatment. Our results suggest that in these two metastatic cell lines integrin-linked N-oligosaccharides influence the VN adhesion receptor activity and function.

9

The C-terminal region of the focal adhesion kinase F1 domain binds akt1 and inhibits pressure-induced cell adhesion

75%

Basson M. D. , Zeng B. , Wang S.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 3

10

Foot metastasis as a first clinical manifestation of rectal carcinoma

75%

Baraniak J. , Krupski W. , Sompor J. , Prystupa A.

Journal of Pre-Clinical and Clinical Research

|

2008

|

tom 02

|

nr 2

11

Flow cytometric analysis of CD133- and EpCAM-positive cells in the peripheral blood of patients with lung cancer

75%

Skirecki T. , Hoser G. , Kawiak J. , Dziedzic D. , Domagala-Kulawik J.

Archivum Immunologiae et Therapiae Experimentalis

|

2014

|

tom 62

|

nr 1

12

Myeloid-derived suppressor cells in the tumor microenvironment: current knowledge and future perspectives

75%

Ibanez-Vea M. , Zuazo M. , Gato M. , Arasanz H. , Fernandez-Hinojal G. , Escors D. , Kochan G.

Archivum Immunologiae et Therapiae Experimentalis

|

2018

|

tom 66

|

nr 2

13

Malignant melanoma of unknown primary site in patient with pustulosis plantaris

75%

Piotr B. , Abdulaziz A. , Andruszkiewicz J. , Chiriac A.

OncoReview

|

2014

|

tom 4

|

nr 2

A69-71

EN

We reported a 57 year old woman treated for 2 years because of pustulosis plantaris (periodic exacerbations and remissions). In July 2013 she reported to the Outpatient Surgery because of a tumor in the left groin area. The biopsy revealed: metastases melanomatosis in lymphonodus. The patients was in October at the surgical removal of lymph nodes from left groin area (lymphadenectomy groin - ilio - obturatorii right). Full diagnostic was carried out and searching of of primary foci to no results. In the patient revealed the presence of BRAF and she was qualified to study of drug vemurafenib.

14

Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells

75%

Wybieralska E. , Koza M. , Sroka J. , Czyz J. , Madeja Z.

Cellular and Molecular Biology Letters

|

2008

|

tom 13

|

nr 1

103-111

EN

The results of several experimental studies have shown that ascorbic acid inhibits tumor growth and metastasis. Ascorbic acid is an antioxidant that acts as a scavenger for a wide range of reactive oxygen species (ROS). Both tumour metastasis and cell migration have been correlated with the intracellular ROS level, so it was postulated that the inhibitory effect of ascorbic acid derivatives on cell motility may be caused by scavenging of ROS. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and the cell displacement were inhibited by ascorbic acid applied in concentrations ranging from 10 to 250 μM. This effect correlated with a reduction in the intracellular ROS level in WC 256 cells, suggesting that ROS scavenging may be a mechanism responsible for the inhibition of WC 256 cell migration. However, another potent antioxidant, N-acetyl-L-cysteine, also efficiently decreased the intracellular ROS level in WC 256 cells, but did not affect the migration of the investigated cells. These results demonstrate that intact, unmodified ascorbic acid applied in physiologically relevant and nontoxicconcentrations exerts an inhibitory effect on the migration of WC 256 carcinosarcoma cells, and that this may be one of the factors responsible for the anti-metastatic activity of vitamin C. However, our data does not support the hypothesis that the scavenging of intracellular ROS is the main mechanism in the inhibition of cancer cell migration by ascorbic acid.

15

Investigation of radiation therapy for gynecologic cancer patients with supraclavicular lymph node metastases

75%

Tanaka O. , Hayashi M. , Hayashi S. , Takayoshi I.

Current Gynecologic Oncology

|

2016

|

tom 14

|

nr 2

85-88

EN

Purpose: The aim of this study was to retrospectively investigate the benefit of radiotherapy for supraclavicular lymph nodes by determining the characteristics and survival of patients with recurrent gynecologic cancer after definitive radiotherapy. Material and methods: We reviewed the treatment outcomes of 18 gynecologic cancer patients with supraclavicular lymph nodes metastases treated. Twelve cervical cancer patients, 4 corporeal cancer patients and 2 ovarian cancer patients were investigated. Tumor responses, adverse events and the overall survival were examined. Results: The median overall survival was 12 months. The 1- and 2-year overall survival rates were 48.6% and 9.7%, respectively. The 2-year local control rate was 75.8%. Following therapy, the symptom of pain was relieved in 2 patients (2/2), and edema and swelling were improved in 6 out of 7 symptomatic patients. Eleven asymptomatic patients did not develop any symptoms during the follow-up period. Common Terminology Criteria for Adverse Events grade 2 toxicities were found in 5 patients (2 dermatitis and 4 hematologic toxicities), and grade 3 toxicities were found in 3 patients (3 hematologic toxicities). Conclusion: Radiotherapy for supraclavicular lymph nodes is effective as palliative irradiation. The 2-year local control rate was 75.8% in patients receiving this therapy, their symptoms improved and asymptomatic patients did not become symptomatic during the follow-up period. Radiotherapy for supraclavicular lymph nodes metastases is therefore recommended for preserving the patient’s life.

PL

Cel pracy: Celem badania była retrospektywna ocena korzyści wynikających z zastosowania radioterapii na okolicę węzłów chłonnych nadobojczykowych poprzez określenie charakterystyki chorych z nawracającymi nowotworami ginekologicznymi po radykalnej radioterapii oraz parametrów ich przeżycia. Materiał i metody: Przeanalizowano wyniki leczenia 18 chorych na nowotwory kobiece z poddanymi terapii przerzutami do węzłów chłonnych nadobojczykowych. Praca obejmowała 12 pacjentek z rakiem szyjki macicy, 4 pacjentki z rakiem trzonu macicy oraz 2 pacjentki z rakiem jajnika. Badano odpowiedź guzów na leczenie, zdarzenia niepożądane oraz całkowity czas przeżycia chorych. Wyniki: Mediana całkowitego czasu przeżycia wyniosła 12 miesięcy, a odsetki rocznych i dwuletnich przeżyć całkowitych – odpowiednio 48,6% i 9,7%. Uzyskano dwuletnią kontrolę miejscową na poziomie 75,8%. Leczenie uśmierzyło ból u 2 pacjentek (2/2), natomiast obrzęk i opuchlizna zmniejszyły się u 6 spośród 7 chorych objawowych. U 11 bezobjawowych chorych nie rozwinęły się w okresie obserwacji żadne objawy. Toksyczność 2. stopnia wg klasyfikacji Common Terminology Criteria for Adverse Events wystąpiła u 5 pacjentek (2 przypadki zapalenia skóry i 4 przypadki toksyczności hematologicznej), natomiast objawy toksyczności 3. stopnia zaobserwowano u 3 chorych (3 przypadki toksyczności hematologicznej). Wniosek: Stosowanie radioterapii na okolicę nadobojczykowych węzłów chłonnych to skuteczny sposób napromieniania paliatywnego. Odsetek dwuletniej kontroli miejscowej u chorych otrzymujących to leczenie wyniósł 75,8%. Odnotowano poprawę w zakresie objawów, a u chorych bezobjawowych nie wystąpiły w okresie obserwacji żadne symptomy. Stosowanie radioterapii w leczeniu przerzutów do węzłów chłonnych nadobojczykowych jest zatem zalecanym sposobem przedłużania życia pacjentom.

16

Intestinal nematode infection afects metastasis of EL4 lymphoma cells

75%

Donskow-Lysoniewska K. , Krawczak K. , Machcinska M. , Brodaczewska K.

Archivum Immunologiae et Therapiae Experimentalis

|

2020

|

tom 68

|

nr 5

17

Epac1 is involved in cell cycle progression in lung cancer through PKC and Cx43 regulation

75%

Sun Q. , Wang D. , Ai G. , Tian L. , Zhao L. , Chen R. , Wang K. , Guo D. , Yao Y. , Liu W. , Kong X. , Chen X. , Zhang Y.

Folia Histochemica et Cytobiologica

|

2018

|

tom 56

|

nr 1

18

Antibody-based antiangiogenic and antilymphangiogenic therapies to prevent tumor growth and progression

75%

Bzowska M. , Mezyk-Kopec R. , Prochnicki T. , Kulesza M. , Klaus T. , Bereta J.

Acta Biochimica Polonica

|

2013

|

tom 60

|

nr 3

EN

Blood and lymphatic vessel formation is an indispensable factor for cancer progression and metastasis. Therefore, various strategies designed to block angiogenesis and lymphangiogenesis are being investigated in the hope to arrest and reverse tumor development. Monoclonal antibodies, owing to their unequalled diversity and specificity, might be applied to selectively inhibit the pathways that cancer cells utilize to build up a network of blood vessels and lymphatics. Among the possible targets of antibody-based therapies are proangiogenic and prolymphangiogenic growth factors from the VEGF family and the receptors to which they bind (VEGFRs). Here, we present molecular mechanisms of angiogenesis and lymphangiogenesis exploited by tumors to progress and metastasise, with examples of antibody-based therapeutic agents directed at interfering with these processes. The expanding knowledge of vascular biology helps to explain some of the problems encountered in such therapies, that arise due to the redundancy in signaling networks controlling the formation of blood and lymphatic vessels, and lead to tumor drug resistance. Nonetheless, combined treatments and treatments focused on newly discovered proangiogenic and prolymphangiogenic factors give hope that more prominent therapeutic effects might be achieved in the future.

19

Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma

75%

Godlewski J. , Kowalczyk A. , Kozielec Z. , Pidsudko Z. , Kmiec A. , Siedlecka-Kroplewska K.

Folia Histochemica et Cytobiologica

|

2013

|

tom 51

|

nr 2

20

The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment

75%

Tokarz P. , Blasiak J.

Acta Biochimica Polonica

|

2012

|

tom 59

|

nr 4

467-474

EN

microRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression by targeting specific mRNAs. microRNAs play a role in several physiological processes in the cell, including migration, proliferation, differentiation and apoptosis. Apart from their role in regular metabolism, abnormal profiles of miRNA expression accompany cancer transformation, including colorectal cancer (CRC) metastasis. microRNAs may play a role in each phase of CRC metastasis including angiogenesis, invasion, intravasation, circulation, extravasation and metastatic colonization. microRNA levels may serve as a predictive CRC marker, which was confirmed by the serum level of miR-29a targeting KLF4, a marker of cell stemness, and the plasma level of miR-221 down-regulating c-Kit, Stat5A and ETS1, which are signal transducers and transcription factor, respectively. In turn, the level of miR-143 in CRC cells decreasing the amount of MACC1 (metastasis-associated in colon cancer-1) and oncogenic KRAS protein, may be utilized as a prognostic marker. Also, single nucleotide polymorphisms of genes encoding miRNAs, including miR-423 and miR-608, which correlate with tumor recurrence, may be useful as diagnostic, prognostic and predictive indicators in CRC metastasis. Pre-miR-34a and pre-miR-199a decreased the level of Axl, a tyrosine-protein kinase receptor, so they can be considered as drugs in antimetastatic therapy. On the other hand, miR-222 targeting ADAM-17, a disintegrin and metalloproteinase, and miR-328 interacting with ABCG2, an ABC transporter, may overcome drug resistance of cancer cells. microRNAs may be considered in wide-range application to facilitate CRC metastasis diagnosis, prognosis, prediction and therapy, however, further clinical, epidemiological and in vitro studies should be conducted to verify their utility.