Clinoptilolite, a natural zeolite from the Semnan region in the West of Iran, has been converted to a catalyst for the methanol dehydration to dimethyl ether process. To produce such a catalyst and to create acidic sites on the latter, the ion-exchange process has been used. In addition, to investigate and optimize the effective factors of the catalyst synthesis process, a L9 Taguchi experimental design method has been implemented. The effects of four factors have been considered: the type of ion-exchange solution (2 levels); ion-exchange solution concentration; calcination temperature and calcination time (the last three factors have been studied in 3 levels). The yield of catalyst (conversion x selectivity) has been chosen as the response of the system. The catalytic behaviour of the produced samples was investigated using a fixed bed reactor (T = 350 oC, P = 1 atm and WHSV = 4.78 h-1 ). The results of the statistical design showed that the optimum conditions were: calcination time - 3 h, calcination temperature - 500 oC, ionexchange solution concentration - 2M, and ion-exchange solution - ammonium chloride. The optimum catalyst was tested using a fixed bed reactor at 330 oC, 1 atm and WHSV= 3.8 h-1 resulting in 98.1% conversion and 96.5% selectivity. In order to investigate the catalyst behaviour under industrial operating conditions, the catalyst was tested in a fixed bed reactor at 300 oC, 16 atm pressure, and WHSV = 52.5 h-1. The results were 67.02% conversion and 99.74% selectivity.