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The presence and location of specific binding sites for progesterone and 17β-estradiol in cells of wheat were estimated using radioligand binding assay. Membrane and cytosolic fractions of non-vernalized and vernalized plants were tested using tritium-labelled ligands. Specific binding of [3H]progesterone and [3H]17β-estradiol occurs in wheat cells. The binding sites are located in membranes and in the cytosol. Specific binding of [3H]17β-estradiol is higher in the membranes than in the cytosol. Specific binding of both ligands in the cytosolic fraction is higher in vernalized plants than in non-vernalized ones. The possibility of the occurrence of steroid binding proteins specific for progesterone and 17β-estradiol, putative steroid receptors for these steroids in Triticum aestivum L., is discussed.
The aim of the study was to estimate the uterus involution and progesterone level after antigestagene therapy in 12 bitches with a closed form of endometritis-pyometra complex (EPC). The bitches were of pure and mixed breeds, between 2 and 13 years of age. All the animals were treated with the same pattern: aglepristone was administrated at the dose of 0.33 mL/kg, s.c. on days 1, 2, 7, and 14. Additionally, amoxycyline was given at the dose of 1 mL/l0kg, s.c. every 48 h for 10 d. Complete elimination of puss masses and uterus involution were observed after 7-14 d of the treatment. Progesterone concentration was highly increased at the beginning of the treatment and was decreasing to low values during the first week of the therapy. Detectable uterus changes in the USG examination and physiological health status are not the only recovery criteria, but, most importantly, lack of recurrence of the EPC and the ability to deliver healthy progeny.
The objective of the present study was to determine the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) representing different chemical groups on progesterone (P₄) production by cultured bovine steroidogenic luteal cells. The cells were enzymatically isolated from corpora lutea collected on days 8-12 of the estrous cycle. After 24 h preincubation they were incubated for 24 h with medium only (control) or stimulated with bovine luteinizing hormone – LH (100 ng/ml; positive control) or increasing concentrations (10⁻⁸ to 10⁻⁴ M) of acetylsalicylic acid, indomethacin, ibuprofen, naproxen, piroxicam, phenylbutazone, dipyrone or nimesulide. Concentartions of P₄ in the culture media were determined by enzyme immunoassay. LH significantly increased P₄ secretion, while acetylsalicylic acid and indomethacin did not affect the production of this hormone. A significant increase in P₄ secretion was observed after administration of dipyrone at all concentrations, piroxicam at concentrations of 10⁻⁸, 10⁻⁷ and 10⁻⁵ M, phenylbutazone and naproxen at concentrations of 10⁻⁷ and 10⁻⁶ M and ibuprofen at concentrations of 10⁻⁵ and 10⁻⁴ M. Nimesulide did not affect P₄ production at concentrations of 10⁻⁸ – 10⁻⁵ M, while at a concentration of 10⁻⁴ M it inhibited P₄ secretion. The results obtained indicate that NSAIDs may change the production of P₄ in bovine luteal cells, however, these changes are dependent on the substance used.
This study investigated an influence of oestradiol and progesterone on expression of LH/hCG receptors in the porcine uterine broad ligament. The tissues were obtained from nineteen ovariectomized crossbred gilts. The animals received i.m. injections of 2 ml of corn oil (control; n=4), 25 μg kg-1 of oestradiol benzoate (n=5), 500 μg kg-1 of progesterone (n=5) or 25 μg kg-1 of oestradiol benzoate with 500 μg kg-1 of progesterone (n=5) daily for 5 consecutive days before slaughter. It was found that oestradiol increased the number of receptors in arteries of all areas in the uterine broad ligament, in veins located near the uterine horn and in the ovarian vein as well as in the ligament musculature in the area of vessels located near uterine horn. Progesterone decreased the expression of receptors in all tissues from the area of vessels located about 4 cm below the uterine horn, but augmented their expression in the ovarian vein and in muscular layers of the broad ligament in the area of the uterine vessels trunk. Oestradiol with progesterone increased amount of receptors in arteries from the area of uterine vessels branches, in ovarian vessels^ in veins from areas of branches and trunk of uterine vessels as well as in muscular layers of the broad ligament collected from areas of uterine vessels trunk and paraovarian plexus. These results indicate that oestradiol and progesterone are responsible for changes in expression and distribution of LH/hCG receptors in the broad ligament of the porcine uterus.
The cytochrome P-450 dependent monooxygenase system is responsible for metabolism of exo- and endogenous compounds. It is induced or inhibited by many factors, including hormones. The effects of hormones on this system depend on the dose, manner and route of administration. The aim of this study was to test a controlled long-acting system of estradiol-progesterone release from a biodegradable copolymer and to evaluate the influence of the copolymer alone, or the copolymer with estradiol or progesterone on the hepatic enzymatic system responsible for biotransformation of xenobiotics. We have shown that the copolymer slightly affects the activity of the cytrochrome P-450 - dependent mixed oxygenase system (MFO), but not the desaturase system. Estradiol and progesterone modified the MFO activity in a typical manner.
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