Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: pro-drug

Sortuj według:

Ogranicz wyniki do:

Hypolipidemic effect of a pro-drug containing nicotinic acid in rats

100%

Filip C. , Albu E. , Gheorghita N. , Ghitler N. , Mocanu G. , Nechifor M.

Open Medicine

2006

tom 1

nr 4

348-355

We studied the release of nicotinic acid from a macromolecular pro-drug containing niacin bound to a polymeric support of dextran. Using a modified High-performance Liquid Chromatography (HPLC) method to provide an improved separation between nicotinic acid and its metabolites, we compared the plasma levels of nicotinic acid 24 h after administration of the pro-drug or a similar dose of unbound nicotinic acid to rats. Nicotinic acid exerts a number of pharmacological activities among which is the hypolipidemic effect. To determine the hypolipidemic effect of the pro-drug, we measured the triglyceride levels and examined the correlation with the plasma levels of nicotinic acid.Starting 6 h after administration of the pro-drug, the plasma levels of nicotinic acid were high enough to cause a decrease in the triglyceride level. These results suggest that nicotinic acid was gradually released from the polymeric support, leading to the sustained presence of the active substance and, therefore, a reduction in the level of triglycerides.

Physicochemical properties of oxprenolol esters pro-drugs

75%

Nogowska M.

Chemia Analityczna

1999

tom Vol. 44, No. 1

97-102

The pKa vallles, Rr va]lIes and partition coefficients of a series of O-acyl and O-aryl oxprenoIoI pro-drllgs were estimated. AII derivatives showed increased lipophi]icity, dlle to lhe introdllclion of a lipophi]ic grollps.

Oznaczono wartości pKa, wartości Rr i wspólczynniki podziałll w serii O-acyIowych i O-aryłowych estrów oksprenoloIu. Wszystkie pochodne wykazllją zwiększoną IipofiI-ność, co jest następstwem wprowadzenia Iipofilnej grupy estrowej.