Introduction: DIPNECH is a very rare condition with under 100 cases reported in the scientific literature worldwide. The new WHO classification of lung tumors considers it as a preneoplastic condition, leading to further growth of pulmonary carcinoid tumors. Prior to that, proliferating neuroendocrine, or NE cells in the respiratory epithelium develop into tumorlets – lesions less than 5mm in the largest size, visible in diagnostic imaging as round shadows and sometimes mistake for metastases of a tumor of unknown origin. Purpose: The goal here is to strongly recommend the foundation of a world wide web (www) based portal with clinical information about DIPNECH, also, if possible, containing reports of all the cases ever diagnosed. This will create an easily accessible source of information, which could increase the rate of diagnosis for this condition. Thanks to further possibilities of scientific exchange and development such as a database could become a vast archive of pulmonary preneoplastic lesions with possible clues to understanding mechanisms of carcinogenesis. Discussion: It is yet unclear, if DIPNECH could be a predecessor of other neuroendocrine tumors, at least being one of their possible origins, or is the growth of NE cells around the primary neuroendocrine tumor a reaction for airway obstruction and hypoxia. Conclusion: According to information gathered through electronic search, further scientific investigation of DIPNECH might be very helpful in understanding carcinogenesis in lung.
Celem pracy było zbadanie wpływu chlorfenwinfosu, w dawce jednorazowej, na stężenie mleczanów i glukozy w surowicy krwi oraz na obraz glikogenu w wątrobie.
EN
The aim of this work was to estimate the effect of chlorphenvinphos on the concentration of lactate and glucose in blood serum and glycogen in the liver. The test animals received oil alone or oil solution of chlorphenvinphos at 0.5 or 0.1 LD50. The test material was collected at hour 1, 24 and 48 since the exposure. The following were assayed: serum glucpse by the Biochem Test, serum lactate by the Sigma test, and liver glycogen by the histological method. It was found that exposure to a single dose of chlorphenvinphos resulted in reduced number of glycogen granules, vacoulated degeneration of hepatocytes and colliguative necrosis. The changes were more evident in the animals exposed to the higher dose of the pesticide. The acute poisoning with chlorphenvinphos resulted also in hyperglycaemia and lactate acidosis.
Nowotwory neuroendokrynne głowy i szyi stanowią rzadki rodzaj nowotworu. Najczęstszym miejscem lokalizacji nowotworów neuroendokrynnych głowy i szyi jest krtań, zwłaszcza nagłośnia i okolica nadgłośniowa. Pierwszy opisany przypadek neuroendokrynnego raka krtani został przedstawiony w 1969 roku przez Goldmana i wsp. Wśród cech guzów neuroendokrynnych, wykrywanych w badaniach immunohistochemicznych, należy wymienić ekspresję dwóch kluczowych markerów: synaptofizyny i chromograniny wraz z cząsteczką adhezji komórek nerwowych (CD56). Wykrycie zakażenia wirusem brodawczaka ludzkiego (HPV 16/18) w neuroendokrynnym raku krtani może stanowić jeden z czynników etiologicznych i powinno być traktowane jako standardowa procedura w diagnostyce i terapii. Metody: Przegląd artykułów opublikowanych w czasopismach na całym świecie; interdyscyplinarne konsylium pomiędzy patologami a klinicystami na temat nowotworów neuroendokrynnych głowy i szyi.
Neuroendocrine carcinoma is a rare neoplasm, and its most common location in the head and neck area is the larynx, especially the epiglottis and the supraglottic region. The first case of neuroendocrine carcinoma of the larynx was reported in 1969 by Goldman et al. Expression of the two crucial markers, synaptophysin and chromogranin, along with neural cell adhesion molecule (CD56) should be mentioned among the neuroendocrine features detected on immunohistochemistry. Human papilloma virus (HPV16/18) infection in the laryngeal neuroendocrine carcinoma can be one of the causal factors, and the detection of HPV should be considered as a standard procedure for the diagnosis and treatment.