Wyniki wyszukiwania - Biblioteka Nauki

1

Malignant mixed mullerian tumor in two patients receiving tamoxifen therapy

100%

Koukouliata A.

Progress in Health Sciences

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2011

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tom 1

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nr 1

167-170

EN

Patients with breast cancer exhibit an increased risk in developing neoplasms of other organs. In the case of the endometrium, the increased risk might be due to tamoxifen adjuvant therapy. We present two cases of homologous malignant mixed mullerian tumor (MMMT) of the uterine in two women, 77-year-old and 76-year-old, respectively, after tamoxifen treatment for postmenopausal breast cancer with positive estrogen receptors. The findings for two patients were studied and compared with similar ones discussed in the relevant literature.

2

The pulmonary embolism after switching from letrozole to tamoxifen in a patient with breast cancer. A case report and literature review

100%

Tomaszewska A. , Żach-Muzolf M. , Grabysa R.

OncoReview

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2020

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tom 10

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nr 1

31-36

EN

Women with breast cancer are affected by deep venous thrombosis and/or pulmonary embolism 3 times more often than the group of healthy women in the same age. Thrombosis can be the first manifestation of a malignant disease, but it can also result from hormonal therapy with aromatase inhibitors or tamoxifen which is used in cancer treatment. The necessary clinical problem to solve in this population is the issue of prophylactic antithrombotic treatment. In this paper we present a case of pulmonary embolism in the course of the breast cancer, which was associated with tamoxifen hormone therapy and inadequate thromboprophylaxis.

3

Can transforming growth factor-β1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?

75%

Czeczuga-Semeniuk E. , Anchim T. , Dzięcioł J. , Dąbrowska M. , Wołczyński S.

Acta Biochimica Polonica

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2004

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tom 51

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nr 3

733-745

EN

Retinoic acid and transforming growth factor-β (TGF-β) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [3H]thymidine incorporation and the proliferative activity of PCNA- and Ki 67-positive cells. The apoptotic index and expression of the Bcl-2 and p53 antigens in MCF-7 cells were also determined. Exogenous TGF-β1 added to the cell culture showed antiproliferative activity within the concentration range of 0.003-30 ng/ml. Irrespective of TGF-β1 concentrations, a marked reduction in the stimulatory action of estradiol (10-9 and 10-8 M) was observed whereas in combination with tamoxifen (10-7 and 10-6 M) only 30 ng/ml TGF-β1 caused a statistically significant reduction to aproximately 30% of the proliferative cells. In further experiments we examined the effect of exposure of breast cancer cells to retinoids in combination with TGF-β1. The incorporation of [3H]thymidine into MCF-7 cells was inhibited to 52 ± 19% (control =100%) by 3 ng/ml TGF-β1, and this dose was used throughout. It was found that addition of TGF-β1 and isotretinoin to the culture did not decrease proliferation, while TGF-β1 and tretinoin at low concentrations (3 × 10-8 and 3 × 10-7 M) reduced the percentage of proliferating cells by aproximately 30% (67±8% and 67±5%, P <0.05 compared to values in the tretinoin group). Both retinoids also led to a statistically significant decrease in the stimulatory effect of 10-9 M estradiol, attenuated by TGF-β1. In addition, the retinoids in combination with TGF-β1 and tamoxifen (10-6 M) caused a further reduction in the percentage of proliferating cells. Immunocytochemical analysis showed that all the examined compounds gave a statistically significant reduction in the percentage of cells with a positive reaction to PCNA and Ki 67 antigen. TGF-β1, isotretinoin and tretinoin added to the culture resulted in the lowest percentage of PCNA positive cells. However, the lowest fraction of Ki 67 positive cells was observed after addition of isotretinoin. The obtained results also confirm the fact that the well-known regulatory proteins Bcl-2 and p53 play an important role in the regulation of apoptosis in the MCF-7 cell line, with lowered Bcl-2 expression accompanying easier apoptotic induction. The majority of the examined compounds act via the p53 pathway although some bypass this important proapoptotic factor.

4

Bipolar affective disorder: A review of novel forms of therapy

75%

Dziwota E. , Drapala B. , Gaj M. , Skoczen N. , Olajossy M.

Current Issues in Pharmacy and Medical Sciences

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2015

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tom 28

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nr 2

105-110

EN

Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD). Long-term studies on the mechanisms of action of such medications, as well as on the pathogenetic background of BD, have led to the discovery of effective, albeit unconventional pharmacotherapeutic approaches. These methods have the potential to successfully treat mania and depression, as well as to counter affective episode relapse. Allopurinol - commonly used to treat gout, secondary hyperuricemia and Lesch-Nyhan syndrome, acts by inhibiting the synthesis of uric acid, levels of which are often increased in manic patients. Due to this, an evaluation of the potential effect of allopurinol on the reduction of mania symptoms seems to be reasonable. Additionally, the numerable research papers coming out of research regarding the role of purine neurotransmitters in mood alterations, indicate that adenosine agonists act analogously to dopamine antagonists. N-acetylcysteine (NAC), a supporting agent in the pharmacotherapy of depressive episodes in bipolar disorder, substantially accelerates mood stabilization in patients. In turn, memantine, known for its procognitive effect, not only has antimanic and normothymic properties, but also boosts the neuroprotective action of traditional lithium therapy. In view of the latest opinions, the subtle pro-inflammatory process is typical for the pathophysiology of bipolar disease. Acetylsalicylic acid (ASA) (a popular analgesic, antipyretic and antiphlogistic agent) may be useful in BD therapy. This is because that, via its effect upon cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), ASA modulates leukocyte recruitment in neuro-inflammation. Apart from the above-mentioned medications, this article introduces the results of recent investigations of ketamine, modafinil and tamoxifen, including their receptor mechanisms, as well as certain genetic aspects or elements of their pharmacodynamics, for use in BD therapy. We put forward that, possibly, more insightful cognition of these drugs will allow significant enrichment in the range of pharmacotherapy for BD in the near future.

5

Tamoxifen and vitamin E treatments delay symptoms in the mouse model of Niemann-Pick C

75%

Bascunan-Castillo E. C. , Erickson R. P. , Howison C. M. , Hunter R. J. , Heidenreich R. H. , Hicks C. , Trouard T. P. , Gillies R. J.

Journal of Applied Genetics

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2004

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tom 45

|

nr 4

6

Influence of chronically administered tamoxifen and sodium fluoride on tissues of the oral cavity in rats

75%

Mielcarek-Samochowiec K. , Put A. , Juzyszyn Z. , Samochowiec J.

Acta Poloniae Toxicologica

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2000

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tom 08

|

nr 2

7

Effects of cytostatics on the selected parameters of cell-mediated immunity in dogs

63%

Brodzki P. , Wrona Z. , Piech T. , Brodzki A.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

|

nr 1

EN

The aim of the study was to assess the effects of tamoxifen and cyclophosphamide on the selected cell-mediated immunity parameters in dogs. The study included 18 dogs aged 5-10 years. The experimental group consisted of 12 animals with neoplastic lesions classified as the first or second staging group (according to the WHO TMN classification). This group was divided into two subgroups: I - six dogs receiving oral tamoxifen, and II - six dogs with cyclophosphamide administered orally. The control group included six healthy dogs. The blood was sampled from the saphenous access vein two times at 14-d intervals before the drug administration, three times every 7 d during administration, and two times every 14 d after completion of the therapy. The basic blood tests were carried out and the subpopulations of TCD4+ and TCD8+ lymphocytes, and phagocytic activity of granulocytes and monocytes were determined using flow cytometry. It was found that tamoxifen induced a marked increase in WBC and neutrophil counts, increased phagocytic activity of monocytes, and changed the CD4+:CD8+ ratio (in favour of cytotoxic lymphocyte subpopulation). These findings indicated the stimulation of cell-mediated immunity mechanisms. Cyclophosphamide caused a substantial decrease in the overall leukocyte pool and reduced the percentage of cells activated for phagocytosis, both neutrophils and monocytes even after completion of its administration, which proves its immunosuppressive effects.

8

Effect of tamoxifen on morphology and activity of oxidative enzymes in the liver, stomach, and kidneys of rats

63%

Kuzna-Grygiel W. , Kolodziejczyk L. , Czerny B. , Put A.

Acta Poloniae Toxicologica

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2000

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tom 08

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nr 2

9

Influence of tamoxifen on sexual impulse and semen biological values in male dogs

63%

Brodzki P. , Wrona Z. , Krakowski L. , Brodzki A.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

|

nr 3

EN

The study was conducted on 12 male dogs (5 to 10 years of age). The animals were divided into 2 groups: the experimental one (6 tamoxifen-treated dogs) and the control one (6 clinically healthy dogs). Besides, a clinical examination evaluating the overall state of health and sexual impulse, the examination of testosterone level in the blood serum was performed as well as the examination of semen (spermatozoa concentration, percentage of dead spermatozoa, evaluation of spermatozoa morphology, and evaluation of spermatozoa cell membrane activity - HOS test). It was found that tamoxifen had a negative influence on the function of the reproductive system in the dogs and caused, already in the first week of the treatment, the worsening of most of the evaluated characteristics of the semen and later, after the second week of the treatment, it produced aspermia with the complete loss of male fertility. The loss of fertility turned out to be periodical and lasted for about 60 d. After that time, the dogs regained the ability to produce ejaculate, though of much weakened quality, but later it was gradually improving.

10

Can transforming growth factor-beta1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?

63%

Czeczuga-Semeniuk E. , Anchim T. , Dzieciol J. , Dabrowska M. , Wolczynski S.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 3

EN

Retinoic acid and transforming growth factor-ß (TGF-ß) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [ 3H] thymidine incorporation and the proliferative activity of PCNA- and Ki 67-positive cells. The apoptotic index and expression of the Bcl-2 and p53 antigens in MCF-7 cells were also determined. Exogenous TGF-ß1 added to the cell culture showed antiproliferative activity within the concentration range of 0.003-30 ng/ml. Irrespective of TGF-ß 1 concentrations, a marked reduction in the stimulatory action of estradiol (10-9 and 10-8 M) was observed whereas in combination with tamoxifen (10 -7 and 10 -6 M) only 30 ng/ml TGF-ß 1 caused a statistically significant reduction to aproximately 30% of the proliferative cells. In further experiments we examined the effect of exposure of breast cancer cells to retinoids in combination with TGF-ß 1. The incorporation of [3H]thymidine into MCF-7 cells was inhibited to 52 ± 19% (control = 100%) by 3 ng/ml TGF-ß1, and this dose was used throughout. It was found that addition of TGF-ß1 and isotretinoin to the culture did not decrease proliferation, while TGF-ß1 and tretinoin at low concentrations (3 x 10 -8 and 3 x 10-7 M) reduced the percentage of proliferating cells by aproximately 30% (67±8% and 67±5%, P < 0.05 compared to values in the tretinoin group). Both retinoids also led to a statistically significant decrease in the stimulatory effect of 10-9 M estradiol, attenuated by TGF-ß1. In addition, the retinoids in combination with TGF-ß1 and tamoxifen (10–6 M) caused a further reduction in the percentage of proliferating cells. Immunocytochemical analysis showed that all the examined compounds gave a statistically significant reduction in the percentage of cells with a positive reaction to PCNA and Ki 67 antigen. TGF-ß1, isotretinoin and tretinoin added to the culture resulted in the lowest percentage of PCNA positive cells. However, the lowest fraction of Ki 67 positive cells was observed after addition of isotretinoin. The obtained results also confirm the fact that the well-known regulatory proteins Bcl-2 and p53 play an important role in the regulation of apoptosis in the MCF-7 cell line, with lowered Bcl-2 expression accompanying easier apoptotic induction. The majority of the examined compounds act via the p53 pathway although some bypass this important proapoptotic factor.

11

The effect of doxorubicin and retinoids on proliferation, necrosis and apoptosis in MCF-7 breast cancer cells

63%

Czeczuga-Semeniuk E. , Wolczynski S. , Dabrowska M. , Dzieciol J. , Anchim T.

Folia Histochemica et Cytobiologica

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2004

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tom 42

|

nr 4

12

Can vitamin A modify the activity of docetaxel in MCF-7 breast cancer cells?

51%

Czeczuga-Semeniuk E. , Lemancewicz D. , Wolczynski S.

Folia Histochemica et Cytobiologica. Supplement

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2007

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tom 45

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nr 1

169-174

13

Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats

51%

Schendzielorz N. , Rysa A. , Reenila I. , Raasmaja A. , Mannisto P. T.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 4

14

Estrogen receptor beta participate in the regulation of metabolizm of extracellular matrix in estrogen alpha negative breast cancer

51%

Lesniewska M. , Miltyk W. , Swiatecka J. , Tomaszewska M. , Kuzmicki M. , Palka J. , Wolczynski S.

Folia Histochemica et Cytobiologica

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2009

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tom 47

|

nr 5

15

Oestrogen effects on kainate-induced toxicity in primary cultures of rat cortical neurons

51%

Kajta M. , Lason W.

Acta Neurobiologiae Experimentalis

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2000

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tom 60

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nr 3