Wyniki wyszukiwania - Biblioteka Nauki

1

Inadvertent epidural infusion of paracetamol in an elderly patient

100%

Dehne M.

Open Medicine

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2011

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tom 6

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nr 5

595-597

EN

A 76 year old patient underwent a laparoscopic rectal resection performed under thoracic epidural anaesthesia and general anaesthesia. He was inadvertently given 1 g of paracetamol epidural and reported a position-independent holocephalic headache one day later. A severe nausea and vomiting lead to a gastrointestinal bleeding. The last neurological examination after 3 months revealed no nausea, no headaches and no sensory disturbances.

2

Effects and treatments of paracetamol toxicity

100%

Adio W. S. , Yinusa I. O. , Adesola R. O. , Olawale L. A. , Moradeyo A. T. , Ademilua A.

World Scientific News

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2022

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tom 170

69-84

EN

Paracetamol (acetaminophen) is the most widely used over-the-counter analgesic and antipyretic agent in the world. It can be synthesized by original and green synthesis methods from phenol compound. Excessive intake of the medication paracetamol that is, above recommended dose of paracetamol; 4 g or 75 mg/kg in 24 hours for an adult result into overdose. Overdose of paracetamol can induce temporary liver dysfunction or even liver failure with some other complications like pancreatitis, low blood sugar and lactic acidosis etc. Paracetamol metabolism is broadly categorized into two phases (reactions); oxygenation and conjugation reactions. When paracetamol poisoning is suspected, N-acetyl cysteine should be given to replenish glutathione levels in the body. In less than 2 hours after taking paracetamol, activated charcoal can be used to treat the overdose, or gastric lavage can be performed between 2-4 hours. Patients with a serum paracetamol concentration more than 200 mg/L should be given the antidote N-acetyl cysteine, which ensures survival. When given within 8 hours of paracetamol administration, the efficacy declines as the treatment time is extended. Despite the fact that paracetamol is widely available and effective, it is vital to use caution when administering the medicine to avoid overdosing and consequences from paracetamol poisoning.

3

Nephroprotective role of Potentilla reptans L. aqueous extract on paracetamol - induced kidney nephrotoxicity in male mice

88%

Muthulingam M. , Prabhahar C. , Senthilmurugan S. , Pugazhendy K. , Vijayan P. , Baranitharan M.

World News of Natural Sciences

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2021

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tom 39

76-85

EN

Nephroprotective effects (NPE) of simple Potentilla reptans - aqueous leaf extract (Pr-ALE) leaves on Paracetamol induced kidney poisonousness in wistar rats. Adult male wistar rats (weight range (WR): 200-220g) were divided into 6 groups (n=6). Paracetamol (PA) and Silymarin (SY) stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Furthermore, a significant nephroprotective (NP) of the aqueous leaf extract (ALE) and oral dose of PA and SY. Pr-ALE did not mortality or significant changes in the body weight. Progression of nephrotoxicity (NT) induced by PA in rats was interfered by Pr-ALE managed, and these effects were correspond to those managed with SY. This is the first record on NPE of Pr against PA-induced NT.

4

Implementation of different separation techniques for resolving ternary mixture of Paracetamol, Pseudoephedrine Hydrochloride and Chlorpheniramine maleate with further quantification

88%

Farid J. F. , Mostafa N. M. , Essam H. M. , Fayez Y. M.

Acta Chromatographica

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2022

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tom Vol. 34, no. 3

351--360

EN

Due to the wide applicability of separation techniques that rely on the property of differential migration in pharmaceutical formulations analysis, different analytical strategies have been proposed to resolve mixtures of multi-components pharmaceuticals. Three separation methods were developed and validated for the simultaneous determination of Paracetamol (PAR), Pseudoephedrine HCl (PSE) and Chlorpheniramine maleate (CHP). The first method is a thin-layer chromatographic (TLC) separation, followed by densitometric measurement. The separation was carried out on aluminium sheet of silica gel 60 F254 using ethanol:chloroform:ammonia (1:7:0.4, by volume) as the mobile phase. Determination of PAR, PSE and CHP was successfully applied over the concentration ranges of 3–25 µg/band, 0.5–10 µg/band and 0.1–6 µg/band, respectively. The second method is HPLC separation that was achieved on C18 column using the mobile phase acetonitrile:phosphate buffer pH 5 (10:90, v/v) at a flow rate 1 mL min⁻¹. PAR, PSE and CHP were determined by HPLC in concentration ranges of 5–400 μg mL⁻¹, 2–40 μg mL⁻¹ and 0.5–16 μg mL⁻¹, respectively. The third method is a capillary electrophoresis (CE) separation. The electrophoretic separation was achieved using 20 mM phosphate buffer (pH 6.5) at 20 kV. The linearity was reached over concentration ranges of 30–250 μg mL⁻¹, 5–50 μg mL⁻¹ and 0.8–20 μg mL⁻¹ for PAR, PSE and CHP, respectively. The developed methods were validated with respect to linearity, precision, accuracy and system suitability. The proposed methods were successfully applied for bulk powder and dosage form analysis with RSD of precision <2%. Moreover, statistical comparison with the official methods confirms the methods' validity.

5

Comparative Test of Physicochemical Parameters and Microbiological Quality of Different Brands of Paracetamol Tablets Sold in Nigeria

75%

Alabere H. O. , Lucky E. I. , Ogundare A. O. , Akinwunmi A. I. , Abimbola T. Y.

World Scientific News

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2020

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tom 141

12-23

EN

Paracetamol also known as acetaminophen is a widely used antipyretic and analgesic agent. The therapeutic efficacy of pharmaceutical products depends on both microbial and physicochemical qualities of the products, hence, the need to routinely assess the pharmaceutical quality of the available brands of the tablets to ensure they conform to standard specifications. This study was done to evaluate the microbial and physicochemical qualities of 10 brands of paracetamol tablets sold in Nigeria. The purchased drug samples were evaluated for their uniformity of weight, crushing strength, friability, disintegration time, total viable aerobic count and content of active ingredient. These tests were performed by standard methods and techniques following official pharmacopoeia protocols. The investigated 10 brands of paracetamol tablets passed the standards of the British Pharmacopoea (BP) regarding microbial specifications. The tablets were uniform in weight with crushing strength 5 KgF - 12 KgF except a brand with crushing strength ranging between 15 KgF – 18 KgF and another brand which has no crushing strength. The disintegration times were within 15 minutes except a brand with a disintegration time of 27 minutes 44 seconds. Friability values were less than 1%. The % content of paracetamol as an active ingredient in the tablets ranges from 90-110%. 8 out of 10 brands of the paracetamol tablets assessed met all compendia standards. However, products of good quality can be guaranteed through quality control and adherence to the provisions of good manufacturing practices. Also, a routine sentinel market surveillance of pharmaceutical products is encouraged.