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The paper discusses the means in which exercise hormonal data are transformed and expressed as a way to deal with the inherent variability in endocrine measurements. Specifically, the aim of the paper is to present an alterative transformation adjustment method for expressing the exercise responses of hormones, especially those which exhibit a diurnal behaviour in their circulating concentrations. The suggested alterative adjustment method attempts to account for the influence of the "range effect" on diurnal hormonal data and the subsequent effects it may have on statistical, and perhaps physiological, outcomes and data interpretation.
The aim of this study was to evaluate vitamin B12 and folate levels, thyroid functions, sex hormones and bone mineral density in idiopathic epileptic patients taking oxcarbazepine as monotherapy. Newly diagnosed pediatric patients with idiopathic partial epilepsy taking oxcarbazepine (OXC) as monotherapy were enrolled in this study. The pre-treatment and 6 months post-treatment values of vitamin B12, folate, thyroid functions, sex hormones, and bone mineral density (BMD) were obtained from all patients. A total of 32 patients (22 (68.8%) males and 10 (31.2%) females) were included in this study. The mean age was 7.4 ± 3.2 years (range: 2–14 years). There were no significant differences between the pre-treatment and 6 months post-treatment values of vitamin B12, folate, thyroid functions, sex hormones, and BMD. However, the 6 month post-treatment sex hormone binding globulin (SHBG) values (159.92 ± 48.14 nmol/L) were significantly higher than the pre-treatment values (137.88 ± 43.12 nmol/L) (p=0.009). We found that OCX treatment in children did not have an effect on serum folate and vitamin B12 levels, thyroid functions, sex hormones and BMD but caused increased SHBG. Over time, the increase in serum SHBG levels may lead to diminished bioactivity of sex steroids, and thus to reduced fertility. The further studies are needed to demonstrate the clinical importance of increased SHBG levels.
Study aim: The purpose of this study was to assess the physiological cost of three consecutive official boxing fights played during a 3-day tournament and two non-contact specific drills against handheld pads of the same time-profile as the contest, 4 × 2 minutes with 1-minute intervals between them. This assessment was based on the determination of selected hormones and metabolites in the blood sampled directly prior to the contests and throughout short-term post-contest recovery. Material and methods: A female amateur boxer was enrolled on the study during a 3-day Polish Boxing Championship, where one match was played on each day. The timing of capillary blood sampling during each match and the drill was as follows: 10 minutes prior to the effort, and 3 and 30 minutes after its completion. Cortisol (C), testosterone (T), and glucose (G) were determined in the serum, while lactate (LA) was determined in the blood. In addition, prior to each effort, serum creatine kinase (CK) and urea (U) was determined. Directly after each effort, the perception of fatigue (PF) was rated. Results: G, C, and T during official matches were significantly higher than those during non-contact drills. Post-event G, C, T, and LA were higher compared to pre-event values. Conclusions: An official boxing match produced higher stress than a drill of the same time-profile and similar modality. Changes in blood indices corresponded well with the perception of fatigue.
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