Wyniki wyszukiwania - Biblioteka Nauki

1

Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis

100%

Mona Bargotya M. , Ankita Mehta A. , Payel Das P. , Ashish Sachan A.

European Journal of Clinical and Experimental Medicine

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2020

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nr 1

59-63

EN

Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas.It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.

2

Adenocarcinoma of the Small Bowel – A Case Report

100%

Kulesza J. , Meszka M. , Rykała C. , Pawlak J.

Polish Journal of Surgery

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2015

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tom 86

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nr 6

285-288

EN

The paper presents a rare case of a patient with adenocarcinoma of the small intestine who reported to the hospital due to non-specific gastrointestinal symptoms. Following diagnostic examinations, the patient underwent a surgery. The post-operative period proceeded with no complications. The case presented below confirms the usefulness of imaging examinations (abdominal CT) when pathologies within the small intestine are suspected. An accurate interpretation of the result was an indication for a surgical intervention, but the final diagnosis is still established on the basis of the histopathological examination

3

Primary Adenocarcinoma of the Appendix – A Case Report

100%

Pasternak A. , Pach R. , Szura M. , Solecki R. , Tomaszewski K. A. , Szczepański W. , Matyja A. , Kulig J.

Polish Journal of Surgery

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2015

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tom 86

|

nr 7

333-336

EN

Primary adenocarcinoma of the vermiform appendix is a rare clinical condition. It usually presents as an acute abdominal process or as a mass in the right lower quadrant. The gross pathologic and microscopic characteristics of this disease are the same as for colon carcinoma and carry a serious prognosis. We report a case of a 64-year old male patient presenting symptoms of acute appendicitis. The patient underwent laparoscopic appendectomy that revealed a severely inflamed appendix. Histopathological examination has shown that it was a poorly differentiated, high grade adenocarcinoma invading the periappendicular fat. According to the histopathological findings, a right hemicolectomy was further advised and performed. Right hemicolectomy is the generally recommended method of treatment for invasive adenocarcinoma of the appendix

4

Multifocal colorectal cancer in ulcerative colitis patient with sclerosing cholangitis – case report

100%

Kosmowska A. , Krokowicz P. , Nelke M.

Polish Journal of Surgery

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2020

|

tom 92(6)

51-54

EN

Introduction: U lcerative colitis (CU) is an inflammatory disease predisposing to colorectal cancer. Colorectal cancer in ulcerative colitis is more often metachronous or synchronous. Case report: In this case report we present a patient with multifocal colorectal cancer in the course of CU and operative treatment that was implemented. Additionallyprimary sclerosing cholangitis was diagnosed in this patient post-operatively.

5

Cultivation of circulating tumor cells in esophageal cancer

88%

Bobek W. , Matkowski R. , Gurlich R. , Grabowski K. , Szelachowska J. , Lischke R. , Schutzner J. , Harustiak T. , Pazdro A. , Rzechonek A. , Kolostova K.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 3

6

A rare case of high-grade sarcoma as a true mixed tumor of the parotid gland – case report

88%

Kolary-Siekierska K. , Jałocha-Kaczka A. , Olszewski J.

Polski Przegląd Otorynolaryngologiczny

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2020

|

tom 9(3)

59-64

EN

Introduction: According to the National Cancer Registry, head and neck cancers account for 5.5 to 6.2% of all malignancies, which translates into about 5,500 to 6,000 new cases per year. Salivary gland tumors are a heterogeneous group of cancers, which results from the complex embryogenesis of salivary glands; they are divided into benign and malignant tumors. Common benign tumors include mixed tumors and Warthin tumors. Carcinosarcoma is called a true malignant mixed tumor because the tumor process involves both epithelial and mesenchymal elements. We reported the case of true malignant mixed tumor comprising three components: adenocarcinoma, synovial sarcoma (80%) and osteosarcoma (20%). This tumor develops rapidly and has an adverse course with a tendency to form metastases. Case report: The work presents a case report of a 65-year-old patient who reported to the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics at the WAM Hospital due to a tumor of the right parotid gland. The patient was concerned with the rapid growth of the tumor that occurred within 2 months prior to hospitalization, causing deformation of facial features. ENT examination revealed a polycyclic tumor with limited mobility and asymmetry of the corners of the mouth (lowering on the right side). FNA diagnosed typical cancer cells suggesting malignant growth. The patient was qualified for surgical treatment. Under general anesthesia, the right parotid gland tumor with superficial lobe of the salivary gland and region II cervical lymphadenectomy on this side were removed. The postoperative course was normal. Postoperative histopathological examination described high -rade malignant parotid carcinoma, pT3Nx. The patient was referred to an oncology center to undergo radiotherapy.

7

Neuroendocrine component of different types of the pulmonary carcinoma

88%

Biczysko W. , Mlynarczyk W. , Blotna-Filipiak M. , Przybylowski P.

Folia Morphologica

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1994

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tom 53

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nr 3

8

Patterns of immunohistochemical staining for p53 expression in hyperplastic endometrium and adenocarcinoma

88%

Terlikowski S. , Lenczewski A. , Sulkowska M. , Famulski W. , Sulkowski S. , Kulikowski M.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

|

nr 1

9

Ras oncogene product p21 expression in adenocarcinoma of human endometrium

88%

Miturski R. , Semczuk A. , Jakowicki J. A.

Cellular and Molecular Biology Letters

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1996

|

tom 01

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nr 2

EN

ras-encoded p21 protein expression was investigated immunohistochemically in 10 specimens of human endometrial adenocarcinoma. The control group consisted of 5 proliferative endometrium slides. The analysis was performed by using the biotin-streptavidin-peroxidase AEC detection system. An immunohistochemical histologic H- score according to Nyholm et al. [1] was calculated in a semiquantitative fashion incorporating intensity and distribution of staining. Adenocarcinoma glandular cells stained positively in 6 out of 10 specimens (n=6; H-score 0.71; range 0.3-1.15), whereas adenocarcinoma stromal cells exhibited a reddish-brown color in all specimens analyzed (n=10; H-score 0.83; range 0.3-1.5). Only one out of 5 proliferative endometrium slides stained positively for ras p21 (H-score 0.3). Our observations suggest that in human endometrial adenocarcinomas not only glandular but also stromal cells reacted strongly with monoclonal antibody NCC-RAS-001 raised against ras p21 protein. Enhanced ras p21 expression adenocarcinoma stromal cells in comparison with adenocarcinoma glandular cells may suggest that stromal cells are involved strongly in the neoplasm formation.

10

A correlation between the expression of nucleolar organizer regions [AgNORs] and some clinico-pathological features of sigmorectal adenocarcinomas

88%

Famulski W. , Zalewski B. , Sulkowski S. , Miller-Famulska D. , Sulkowska M.

Folia Histochemica et Cytobiologica

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1999

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tom 37

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nr 2

11

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study

75%

Jakubowska M. , Śniegocka M. , Podgórska E. , Michalczyk-Wetula D. , Urbanska K. , Susz A. , Fiedor L. , Pyka J. , Płonka P.

Acta Biochimica Polonica

|

2013

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tom 60

|

nr 3

323-330

EN

Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.

12

Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma

75%

Bury J. , Szumiło J. , Dąbrowski A. , Ciechański A. , Śliwińska J. , Wallner G.

Polish Journal of Surgery

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2012

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tom 84

|

nr 7

341-347

EN

Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study. Both are potential target for novel therapiesThe aim of the study was to determine the immunostaining of VEGF and survivin in gastric carcinoma and to analyse their relationship to the selected clinicopathological features and survival.Material and methods. Formalin-fixed, paraffin-embedded sections from 41 gastric adenocarcinomas were used for immunohistochemical reaction with monoclonal antibodies against vascular endothelial growth factor and survivin. The results were compared with selected clinicopathological features and survival.Results. Positive immunohistochemical reaction for vascular endothelial growth factor and survivin was revealed in 24 (58,53%) and 30 (73,17%), gastric carcinomas respectively. Vascular endothelial growth factor-negative gastric carcinomas were significantly more common in cases without metastases to regional lymph nodes and distant organs and in less advanced cases. Similar, distant metastases were also statistically less common in survivin-negative carcinomas. The differences in immunohistochemical reactions for survivin between less and more advanced cases almost reach statistical significance. The only factors significantly influenced 1, 2 and 3-year survival were vascular endothelial growth factor and survivin status. Statistically significant higher percentage of survival was noted in patients with vascular endothelial growth factor- and survivin-negative tumors.Conclusions. It seems that vascular endothelial growth factor and survivin play role in local invasion and spread of gastric adenocarcinoma and negatively influences survival. However, further studies are required to assess their true usefulness in the clinical practice.

13

Ból jako efekt uboczny terapii fotodynamicznej i metody jego leczenie

75%

Nawrocka-Musiał D. , Nawrocka E. , Latocha M.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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2017

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tom Vol. 23, nr 1

57--68

PL

Terapia fotodynamiczna postrzegana jest obecnie jako metoda przydatna w leczeniu wielu typów nowotworów w różnym stadium zaawansowania oraz chorób innego pochodzenia. Aktywacja fotouczulacza wybiórczo zgromadzonego w nieprawidłowych komórkach przez światło laserowe o odpowiedniej długości fali, nie dość, że pozwala na oszczędzenie zdrowych, niezaatakowanych procesem chorobowym obszarów, to jest także wysoce skuteczna i dobrze znoszona przez pacjentów. Jednakże często opisywanym przez nich dyskomfortem towarzyszącym leczeniu jest ból. Reakcja bólowa w PDT zależy w dużym stopniu od rodzaju, umiejscowienia i rozmiaru leczonej zmiany chorobowej. Nie bez znaczenia są także inne czynniki charakterystyczne dla PDT jak typ oraz stężenie fotouczulacza, fluencja, gęstość strumienia cząstek, promieniowanie, źródło światła, długość fali, frakcjonowanie naświetlania, wzrost temperatury, wiek i płeć pacjenta oraz fototyp i rodzaj skóry. Współczesna medycyna dysponuje skutecznymi narzędziami w walce z bólem pojawiającym się także w wyniku postępowania terapeutycznego, jak np. PDT. W niniejszej pracy dokonano przeglądu stosowanych dotychczas metod niwelowania i leczenia dolegliwości bólowych towarzyszących fototerapii.

EN

Photodynamic therapy is perceived nowadays as useful method of treating many types of tumors of diverse severity, as well as other diseases. Firstly, the activation of photosensitizing agents selectively accumulated in tumor cells by laser light, suitable for the wavelength of the substance allows to spare healthy, not undergoing disease process regions. Secondly, this procedure is very effective and well tolerated by patients. However, the main side effect described by patients is pain. The pain reaction caused by PDT depends largely on the type, localization and extent of treated lesion. The other typical for PDT factors such as type and concentration of photosensitizing agent, fluence and irradiance, light source and wavelength, fractionated light, temperature increase, patient age and sex, skin phototypes are not insignificant. There are effective methods of controlling the pain occuring during treatment procedures, such as PDT. This article also provides a review of commonly used relieving procedures of pain caused by phototherapy.

14

Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

75%

Niedzielska I. , Niedzielski Z. , Tkacz M. , Orawczyk T. , Ziaja K. , Starzewski J. , Mazurek U. , Markowski J.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

|

nr 1

65-71

EN

The aim of this study was to identify differences in Toll-like receptor (TLR) expression patterns in normal and diseased tissues of patients with polyps and colorectal cancer. Eight patients were included in the study group (aged 38 to 72 years). Sixteen HG-U133A oligonucleotide microarrays were analysed including four of colonic polyps, four of adenocarcinoma with different degree of histological differentiation (2 poorly and 2 highly differentiated), and eight of macroscopically normal tissue. The levels of selected TLR mRNA transcripts were analysed. An analysis of all per cent variability values with regard to malignancy stage increasing from polyp to stages I to III adenocarcinoma, and normal colon mucosa shows a statistically significant relationship for TLR2 (increasing) and TLR3 (decreasing). In polyps, copy numbers of TLR3, TLR4 and TLR5 mRNA were the highest and TLR7 mRNA the lowest. In normal colon mucosa of polyposis patients the highest mRNA copy numbers were observed for TLR3, and the lowest for TLR7. TLR3 may serve as a marker of colon tissue metaplasia and may indicate the tendency of normal tissue to form polyps transforming to colorectal cancer.

15

Beta-actin in human colon adenocarcinoma cell lines with different metastatic potential

75%

Nowak D. , Skwarek-Maruszewska A. , Zemanek-Zboch M. , Malicka-Blaszkiewicz M.

Acta Biochimica Polonica

|

2005

|

tom 52

|

nr 2

EN

Human colon adenocarcinoma LS180 parental cell line and selected variants, characterized by different metastatic capacity were used to examine, whether a correlation exists between β-actin expression, its subcellular distribution and metastatic potential of these cells. Cytosolic fraction (supernatant 105 000 × g), isolated from the tumor cells was used as a source for actin quantification. The higher level of β-actin was observed in the cytosol of three selected sublines to compare with LS180 parental line. Statistically significant increase of β-actin level in highly motile EB3 cells variant should be underlined to compare with the other sublines. Distinct differences in the phenotype of adenocarcinoma cell variants were found, such as the changes in cells shape, cells spreading and ability to attach to the surface of culture dish. Actin cytoskeleton was visualized with fluorescence microscopy application and microfilaments rhodamine-conjugated phalloidin staining. β-actin subcellular localization was done by immunofluorescence staining with monoclonal anti-β actin antibodies. In the elongated cells (LS180, 3LNLN), this isoactin is dispersed in the whole cell body and concentrates in pseudopods and at the leading edges, when in the rounded variant (EB3) β-actin dominates mainly in cortical ring under cellular membrane and it is also seen in the subtle protrusions. Summary of our former (Nowak et al., 2002, Acta Biochim. Polon., 49: 823) and current data lead to the conclusion that there is a distinct correlation between metastatic capacity of examined human colon adenocarcinoma cells, the state of actin polymerization, actin cytoskeleton organization and β-actin expression.

16

5-aminolevulinic acid photodynamic therapy of transplantable colon adenocarcinoma in BALB-c mice

75%

Ziolkowski P. , Symonowicz K. , Osiecka B. J. , Rabczynski J.

Archivum Immunologiae et Therapiae Experimentalis

|

1998

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tom 46

|

nr 5

17

Involvement of CD8plus cells in protective mechanisms in canice mammary adenocarcinomas [short communication]

75%

Nowak M. , Madej J. P. , Rossowska J. , Madej J. A.

Bulletin of the Veterinary Institute in Puławy

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2007

|

tom 51

|

nr 3

EN

The study aimed at demonstration of involvement of CD8+ cells in protective mechanisms in canine mammary gland carcinomas. Material for the studies involved metastases to lungs sampled at autopsy from crossbreed bitches aged 11 to 13 years. The tumours were verified histopathologically as adenocarcinomas. The presence of CD8+ cells infiltrating the examined tumour tissues was estimated in cryo-sections by immunofluorescence methods. Parental tumours free of metastases were accompanied by slight infiltration of CD8+ cells. In the case of metastasing tumours, and especially in their pulmonary metastases, the increased number of CD8+ cells was observed. Taken together, metastasing potential of canine mammary adenocarcinomas was positively correlated with the number of CD8+ cells in the tumour stroma.

18

Nonhistone chromosomal proteins [NHCP] in adenocarcinoma of human endometrium

75%

Miturski R.

Acta Biochimica Polonica

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1995

|

tom 42

|

nr 2

EN

Concentration and electrophoretic pattern of nonhistone chromosomal proteins (NHCP) in cancer and normal endometrium were examined. In normal tissues the NHCP/DNA ratio ranged from 0.6 to 0.8 whereas in malignant tissues from 1.2 to 1.7. Mean nuclear concentration of NHCP was 14.16 pg/cell nucleus of normal endometrium and 33.35 pg/cell nucleus of cancer tissue. The two tissues differed in the electrophoretic pattern. Heavy fractions (>60 kDa — 36%) predominated in normal tissue whereas light fractions (< 30 kDa — 48%) in malignant tissue samples. The percentage of intermediate fractions (30-60 kDa) was similar. Neoplastic endometrium shows, irrespective of the patient's age, a high NHCP content. It seems that NHCP, especially the fraction extracted with 0.35 M NaCl, because of its tissue and cell specificity are involved in neoplasm formation.

19

Treatment of thyroid adenocarcinoma in dog by surgigal resection alone-case report

75%

Adamiak Z. , Brzeski W. , Nowicki M. , Rotkiewicz T. , Babinska I.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2002

|

tom 01

|

nr 1

20

Bcl-2 expression in relation to progesterone and estrogen receptors status in endometrial adenocarcinoma in women

75%

Semczuk A. , Miturski R. , Gogacz M. , Tomaszewski J. , Jakowicki J. A.

Cellular and Molecular Biology Letters

|

1997

|

tom 02

|

nr 2