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1
Content available remote Effects of quantum vacuum fluctuations of the electric field on DNA condensation
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nr 1
157-166
EN
By assuming that not only counter-ions but DNA molecules as well are thermally distributed according to a Boltzmann law, we propose a modified Poisson-Boltzmann equation, at the classical level, as a starting point to compute the effects of quantum fluctuations of the electric field on the interaction among DNA-cation complexes. The latter are modeled here as infinite one-dimensional wires (δ-functions). Our goal is to single out such quantum-vacuum-driven interaction from the counterion-induced and water-related interactions. We obtain a universal, frustration-free Casimir-like (codimension 2) interaction that extensive numerical analysis show to be a good candidate to explain the formation and stability of DNA aggregates. Such Casimir energy is computed for a variety of configurations of up to 19 DNA strands in a hexagonal array. It is found to be many-body.
EN
Our concern in this paper is to review four kinds of mesoporous silica materials which can be used as potential sorbents for pharmaceuticals. It is known that a continuous development of science, medicine and food industry has an effect on contamination of the natural environment. Moreover, many impurities, such as drugs, vitamins or proteins etc., which get into environment from urban and hospital wastes, can also influence on human organisms. Thus, there is a need to control an amount of those compounds, especially in the natural waters and wastewaters [1-4]. In this work, we present four types of silica materials which can be helpful in water purification by using adsorption process.
PL
W konsekwencji napromieniowania materiału biologicznego pojawiają się zmiany o charakterze bezpośrednim i pośrednim. Powstające m.in. liczne reaktywne produkty radiolizy wody mogą reagować ze wszystkimi rodzajami biocząsteczek, które są ważnymi składnikami pokarmowymi. Precyzyjne dobranie dawki w zależności od napromienianego produktu pozwala na takie ukierunkowanie zmian chemicznych, że ich efektem jest poprawa właściwości fizykochemicznych, biochemicznych i technologicznych. Liczne badania prowadzone do tej pory wykazały, że w żywności napromienionej dozwoloną dawką (do 10 kGy) nie występują żadne substancje toksyczne lub kancerogenne oraz, że stosowanie technik radiacyjnych przy zachowaniu obowiązujących zasad bezpieczeństwa nie stwarza zagrożenia dla zdrowia ludzi.
EN
As a consequence of irradiation of biological material, direct and indirect changes appear. Extremely reactive molecules formed as a result of water radiolysis can react with all biomolecules which are essential food components. Doses, precisely chosen, with respect to the irradiated product allow to direct the chemical changes in order to obtain the physicochemical, biochemical and technological improvement. Many investigations proved so far that there were not any toxic or cancerous substances in food irradiated within legislated doses (up to 10 kGy) and that usage of irradiation technique is entirely sale for human health when safety regulations are met.
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EN
The development of diagnostic methods in medicine as well as the progress in the synthesis of biologically active compounds allows the use of selected radioisotopes for the simultaneous diagnosis and treatment of diseases, especially cancerous ones, in patients. This approach is called theranostic. This review article includes chemical and physical characterization of chosen theranostic radioisotopes and their compounds that are or could be useful in nuclear medicine.
EN
The title problem is reviewed in the three main areas of general interest to chemists, biochemists and biologists, i.e. mutual interactions of small molecules, ligand to biomolecule binding and interactions of biomolecules. Physical phenomena, specific and nonspecific, such as hydrogen bonding, self association, hydrophobic interactions, etc., are shown as being defined by NMR spectral parameters in solution and solid state. Diversity of hydrogen bonding encountered in nature is exemplified by the interaction of acetic acid with Watson-Crick vs Hoogsteen faces of adenosine, studied by DNMR in organic solvent at low temperatures. The complementarity of solid state NMR to solution studies of defining the nature of hydrogen bonding is presented in the case of genistein interaction with nitrogen bases. Application of a title method is presented for searching the geometry of complexes formed of organic ligands and biological molecules. General protocol for searching the geometry of complex is presented for the case of topotecan (TPT) interaction with duplex octamer and nicked decamer duplexes of DNA. Interaction of biomolecules is presented for the case of duplex octamer DNMR study showing effects of base pairing and stacking on the b 'H values and insulin aggregation as studied by Pulse Field Gradient NMR spectroscopy leading to relating the radius of molecular aggregate with the diffusion constants. In conclusion it is stated that various NMR techniques in solid and liquid state, coupled with X-ray and MS, constitute modern tool of structural biology in pursue of disclosing functions of biomolecules expressed by their interactions.
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