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Content available remote Droga naukowa Profesora Macieja Wiewiórowskiego
Professor Dr Maciej Wiewiórowski, the Professor Emeritus at the University of Adam Mickiewicz and at the Institute of Bioorganic Chemistry, Polish Academy of Sciences, a distinguished organic chemist of international authority, truly meritorious in the development of natural product chemistry and the implementation of modern research methods in Poland, celebrates the 85"' anniversary of his birthday this year. In recognition of his remarkable achievements in the field of natural product chemistry, a group of his alumni and former coworkers dedicated to him a symposium (specially organized as a part of the Polish Chemical Society Annual Meeting in Lublin 2003) concerning bioorganic chemistry, the field of science in which his achievements were most significant. Professor M. Wiewiórowski was born August 24, 1918, in Bagatelka, (which is in Poznan’s province). He took up a university course in chemistry in 1936, being interrupted by the World War 11, during which he was deeply engaged in the resistance movement, serving in the Polish underground Home Army, AK, and was kept imprisoned for two years by the German Security Service, SI). He picked up the course again in March, 1945, and received the M.Sc. and Ph.D. in chemistry from Poznań University in 1946 and 1950, respectively. The latter degree he got for his studies of alfa isomerism in codeine chemistry, working under the supervision of Prof. Jerzy Suszko. Professor M. Wiewiórowski got his scientific title of associate professor in 1959 and that of full professor in 1969. From 1946 to 1959, he was employed by the Academy Economics, where he filled numerous high posts and organized a research team working in the natural product chemistry. 1 Ie returned to the university, UAM, in 1959, where he was employed till his retirement in 1989, being the Head of the Stereochemistry Department (1967 1980), the Director of the Institute of Chemistry (1969 1973) and a vice-Rector of A. Mickiewicz University (1968 1972). from 1955, lie was additionally employed by the Polish Academy of Science, being the Head successively of the Biochemical Laboratory in the Plants Cultivation Department (1955 I960), the Biochemistry and Alkaloids Structure Department in IHH (1960 1969), the Natural Product Stereochemistry Department, Inst. Org. ('hem. (1969 1980), the Bioorganic Chemistry Department (1980 1988) and the Bioorganic Chemistry Institute in PASc, as the Director from February to July, 1988, when he retired. In 1965, Professor M. Wiewiórowski heeame an associated member and, in 1977, a full member of the PASc. The numerous scientific contacts with (he most significant chemical and biochemical research centers in the world were initiated by Professor M. Wiewiórowski in 1956 1957, when he was a Follow at the University of Vienna in Professor F. Galinowsky's laboratory and then, twice at the National Research (Council of Canada, Ottawa, in 1959 1960 and 1965 1966, working with Dr. I., Marion. Dr, O.K Edwards and Dr. M. Przybylski. In the late Sixties, lie participated in the formation of a new research center in Poznań, the Intercollegiate Institute of Biochemistry, and, because of his initiative, two other institutions, useful to all the research laboratories in and around Poznań, the Instrumental Chemical Analysis Center and the Doctoral Studios Center, were created at UAM. His first scientific object of interest was the structure of alkaloids, particularly those isolated from lupin plants. Research in this field later evolved into a study of an intramolecular catalysis, the nun of which was to examine the mechanism of the enzyme action, using cyclic diamines as model compounds. His second field of scientific interest, undertaken at the end of the Sixties, was the innovatory on a world scale chemical research of nucleic acids, especially concerning their synthesis, structure elucidation, isolation from plant material and role in peptide synthesis. At the end of the Sixties, he created a new research group, based on the young people working under his supervision at the Institute of Chemistry. UAM, and at the Department of Natural Product Stereochemistry, Inst. Org. Chem., PASc, giving them a special education in the field of nucleic acid chemistry. This group, which was, in 1974, moved from the university to a new place in Noskowskiego Street, where the main chemical mid biochemical laboratories were only built in the following years, very soon readied some significant scientific achievements. Moreover, this group constituted the origin of the independent Department in 198(1, which became the Institute of Bioorganic Chemistry, PASc, in 1988, administered by Professor M. Wiewiórowski all the time till his retirement.
PDB format is most commonly applied by various programs to define three-dimensional structure of biomolecules. However, the programs often use different versions of the format. Thus far, no comprehensive solution for unifying the PDB formats has been developed. Here we present an open-source, Python-based tool called PDBinout for processing and conversion of various versions of PDB file format for biostructural applications. Moreover, PDBinout allows to create one's own PDB versions. PDBinout is freely; available under the LGPL licence at
Structure and dynamics of an undecamer DNA duplex containing a single a-anomeric deoxyadenosine residue placed in opposition to a thymidine unit have been studied using simulation of molecular dynamics in aqueous solution. Despite several noticeable devia­tions from the B-DNA duplex structure caused by the anomerisation, such as: West type puckering of the a-anomeric sugar, disrupted base stacking pattern and unstable duplex bending, the formation of a non-classical a-dA-T pair was observed. A novel way of visual presentation of trajectory data allowing high throughput screening of the conformational parameters is presented.
The susceptibility of highly fluorescent luminarine nucleosides to acid promoted anomerization reactions has been studied in order to select a derivative with suitable properties for chemical synthesis of luminarine-labeled oligo(deoxy)ribonucleotides. Both O-acetylated derivatives Ia-c and parent luminarosine IIa, as well as 2'-O-meth-ylluminarosine IIb, and 2'-deoxyluminarosine IIc undergo anomerization at pH = 4 however, at considerably different velocities. In the case of O-protected nucleosides (Ia-c), the anomerization leads to an equilibrium mixture of respective b and a furanosides, the rate and extent of anomerization decreasing in the following order: Ic >> Ia > Ib. Parent nucleosides (IIa-c) bearing free hydroxyls are generally more susceptible to anomerization than the O-acetylated derivatives but a similar order of reactivity (IIc >> IIa > IIb) is observed. In each case, a complex mixture containing both b and a ribopyranosyl and -furanosyl forms is formed. Their structure and anomeric configuration have been proved by 1H and 13C NMR spectroscopy. The results point to 2'-O-methylluminarosine as the fluorophore of choice for further derivatization and chemical introduction into oligo(deoxy)ribonucleotides.
Chemical synthesis of 2'-0-[13C methyl-rCGCGCG and 5-methyl-rCGCGCG using support-aided phosphoramidite method is presented. 2'-0-Methyl guanosine derivative was separated from its 3'-0-methyl counterpart using transient 5',3'-0-silylation with l,3-dichloro-l,l,3,3-tetraisopropyldisiloxane (Markiewicz reagent). The hexamers were obtained in a purity suitable for NMR studies.
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