Solid-state thermoelectric elements, such as thermoelectric (TE) modules, can be used as cooling devices. Small-sized TE modules, characterized by: lack of moving parts, no required refrigerants application as well as variable possible installation and operation positions, allow, in several specified cases, achieving the advantage in cooling process over the conventional refrigeration devices. This paper presents the results of the preliminary numerical determination of energetic efficiency of thermoelectric cooling system, applied for cooling a small-scale experimental room. The heat exchangers used in the cooling system consisted of heat sinks and radiators installed on the both sides of the TE module. The numerical assessment included in this paper, based on a 3D model reflecting the experimental room and thermoelectric cooling system, allowed determining the relation between TE module power supply characteristics and cooling effects, as well as time-related temperature distribution inside the modeled experimental room. The commercial modeling software FLUENT, ANSYS 12.0 by ANSYS Inc. was applied in numerical calculations. The results of the performed laboratory studies were used as a basis for model development, required input data, initial and boundary conditions. The results of laboratory tests showed the influence of amperage of power supply on the efficiency of cooling characteristics, as well as distribution of air temperature inside the experimental room. Calibration and validation of the developed model was also based on the results of laboratory experiment. The obtained results of numerical calculations showed the influence of amperage of power supply on efficiency of cooling characteristics as well as distribution of air temperature inside the experimental room.