Purpose: To examine the relationship between depression and quality of life in elderly patients with glaucoma. Materials and methods: The study was conducted as a descriptive and cross-sectional research. The sample of the work consists of 130 patients aged 60 years and over who were followed up at Mersin University Hospital Ophtalmology Department between 01 October 2016 and 31 March 2017. The data were gathered with Personal Information Form, Geriatric Depression Scale and Modifiye GLAU-QOL 17 Glaucoma Quality of life. Number, percentage, mean, Pearson Correlation, Student`s t test, ANOVA test, Tukey and Games-Howell statistic were used in the evaluation of the data. Results: The mean age of the patients was 67.9±7.27. The mean score of geriatric depression scale of the patients was 15,23±5,52. It was determined that 16,2% of the patiens had possible depression and 62,3% had definite depression. The median Glau–QOL-17 Glaucoma Quality of Life Questionnaire subcale scores of the patients were as follows: daily living (3,58±3,25), driving (3,23±2,53), worry (5,26±3,47), self-assesment (6,4±3,07), psychology (4,08±2,74), feeling oppressed (4,39±2,35) and taking responsibility (3,56±1,86). The mean total score was 34.44±15.29. There was a negative and statistically significant relationship between the age of the patients and the scores of geriatric depression and the scores of age and quality of life. Conclusions: Elderly patients with glaucoma are at a major risk for depression and their quality of life is negatively affected.