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Study aim: To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men and women.Material and methods: A total of 152 young, healthy, non-obese (BMI<30) men (n = 81) and women (n = 71) participated in the study. The following substances were assayed in blood using commercial kits: total plasma homocysteine by fluorescence polarisation immunoassay, plasma glucose - by the oxidase method, and insulin by radioimmunoassay using monoclonal antibodies. From the latter two, the index of insulin resistance (FIRI) was computed.Results: Mean plasma homocysteine concentration in men was significantly (p<0.001) higher than in women (10.3 ± 3.0 and 8.4 ± 2.4 μmol/l, respectively) and that of FIRI was significantly (p<0.001) lower than in women (1.310 ± 0.483 and 1.437 ± 0.420, respectively). Neither in men nor in women were plasma homocysteine concentrations correlated with FIRI.Conclusions: Although no association between circulating homocysteine and FIRI was found in young, non-obese men and women, the existence of such association in Type 2 diabetes cannot be ruled out.
Arabs have a lower incidence of atherosclerosis than other ethnicities, but few studies have examined homocysteine (HCYS) as a risk factor for cardiovascular disease in this population. Here, we investigated the association between serum HYCS levels and risk factors for cardiovascular disease (smoking, hypertension, and family history of diabetes) in Saudi males. A total of 50 smokers and 72 nonsmokers completed a general health questionnaire. In addition, their lipid profiles were measured using routine methods and HCYS levels by high-performance liquid chromatograph with electrochemical detection. Regression analysis showed negative associations between HCYS and glucose (r = −0.22; P < 0.05) as well as family history of diabetes (r = −0.21; P < 0.05). HCYS levels were similar between hypertensive and nonhypertensive smokers, but they were significantly elevated in hypertensive nonsmokers (P = 0.027) and lower in smokers with family history of diabetes (P = 0.01). Levels of HCYS among nonsmokers inversely correlated with history of diabetes and elevated glucose. Nonsmokers’ HCYS levels were significantly elevated in the presence of hypertension and correlated with diastolic blood pressure. Thus, HCYS may be a predictor of hypertension among nonsmokers. Until further trials are conducted, we recommend vitamin B6/folic acid supplementation for the Saudi hypertensive population as an adjuvant therapy.
Study aim: To assess the effects of training on resting plasma levels of homocysteine (Hcy), C-reactive protein (CRP), folic acid, and on the activity of creatine kinase (CK) in competitive male and female wrestlers.Material and methods: Polish elite wrestlers, male MW; n = 11) and female (FW; n = 11), as well as corresponding numbers of untrained, control subjects (MC and FC, respectively), participated in the study. Blood for assays was withdrawn from the antecubital vein in the morning, in pre-prandial state. Homocysteine (Hcy), C-reactive protein (CRP), folic acid and creatine kinase (CK) activity were assayed in plasma.Results: Mean concentrations of Hcy and CRP were in the control groups significantly higher and those of folic acid - lower than in the respective groups of wrestlers. Folic acid levels were negatively correlated with Hcy, especially in wrestlers (r = -0.540; p<0.01). Mean CK activity was significantly (p<0.001) higher in male wrestlers than in male controls or female subjects. No significant correlation between CK and CRP was found.Conclusions: Strength-speed training practiced by elite wrestlers, associated with significantly lower values of Hcy and CRP in them compared with the untrained subjects, may reduce the risk of cardiovascular diseases at later age, like in case of endurance training.
Content available remote The effects of tamoxifen on homocysteine levels in breast cancer patients
Open Medicine
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Tamoxifen is widely used in the treatment of breast cancer and associated with an increased risk of thromboembolism (TE). An elevated homocysteine is one of the risk factors for TE. The aim of the study was to assess the effect of tamoxifen on serum homocysteine levels in breast cancer patients. We performed a case-control study in 20 female subjects to evaluate the relationship between homocysteine levels, and 5,10-methylenetetrahyrofolate reductase (MTHFR) C677T and dihydrofolate reductase (DHFR) 19-bp intron-1 deletion polymorphisms in breast cancer patients and in control subjects. It was observed that homocysteine levels were decreased during tamoxifen therapy, but this finding was not statistically significant. There was also no statistically significant difference in homocysteine levels between the two groups (p> 0.05). MTHFR C677T and DHFR 19-bp deletion polymorphisms were not associated with serum homocysteine value in either group.
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