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We analyzed the clinicopathological features and survival rates of the patients with renal cell carcinoma younger than 50 years old. Between 2004 and 2007, 28 patients between 19–49 years underwent surgery for renal cell carcinoma. Presenting symptoms, type of the surgery performed, postoperative outcomes and duration of follow-up were recorded. Mean age was 41.5±7.6 years and 75% of patients were male. The tumor was symptomatic in 19(67.9%) and incidental in 9(32.1%) patients. Radical nephrectomy and nephron-sparing surgery were performed in 18(64.3%) and 10(35.7%) patients, respectively. The most common histologic type was clear cell(67.9%). The mean tumor diameters were 3.5±0.95 and 7.4±5.2 cm in the incidental and symptomatic groups, respectively(p=0.035). Incidentally discovered tumors and tumors treated by NSS did not include Fuhrman grade 4. There were no differences regarding pathological stage and Fuhrman grades when patients were grouped according to their symptomatology(p=0.242 and p=0.265, respectively). Overall mortality was 17.9%(n=5) whereas 4 patients(14.3%) died because of cancer. The mean survival was 30.6 months and cancer specific survival rate was 85.2%. Most of the tumors in this age group were symptomatic and most common histologic subtype was clear cell carcinoma. Incidentally discovered tumors had statistically significant lower tumor size.
Renal cell carcinoma to the uterus is rare. We describe a 52-year old lady who presented with progressive abdominal distension and computerized tomogram scan of the abdomen showing two pathologies; uterine and right renal tumour. It was initially thought to be two distinct tumours (double pathology). Radical nephrectomy and total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed concurrently. Histopathological evaluation of the uterine and right renal tumour however surprised us with a rare form of metastasis from a renal tumour to the uterus. The method of differentiating primary renal cell carcinoma with uterine metastasis, from primary uterine carcinoma with renal metastasis, via immunohistochemistry, is described.
The Internet is a medium whose capabilities are used in many areas of life. Creating ample opportunities for transmissionof information, whether in the form of the written word, sound, image, facilitating networking and maintaining a large circle of newfriends, inviting them to participate in the three-dimensional games taking place in virtual reality, and providing an innovativeway for shopping or advertising, cyberspace brings unprecedented attractiveness. This feature, however, has become a causeof the increasing number of reports of disturbing, difficult to unambiguously classify, behaviour of people using the network.Among the indisputable advantages associated with allowing the use of Internet resources, emerge temptations and dangerslying in wait for its users from the dark side. This applies above all to people with an unformed world view, those with low levelsof knowledge or an underdeveloped personality. The high risk group are young people, shaping their view of the world based onknowledge acquired, also via the Internet. The problem of Internet abuse is the subject of discussion across many fields of scienceyet the phenomenon has not been clearly identified and defined. Increased awareness of the associated risks, and conclusionsmade at the level of research, make it necessary to define the concepts related to the phenomenon of pathological Internet useand adoption of uniform diagnostic criteria. There is also a need for the urgent implementation of preventive and therapeuticprograms, targeting people at risk of addiction to life in the virtual world.
The seasonal variations and pathological manifestation of the acanthocephala infestation were investigated from southeast coast of India. The adult worms’ proboscis is cylindrical, the length and width ranging between 1.2-7.3 cm and 1.0-1.8 mm respectively. Caranx ignobilis was the major host in terms of prevalence and intensity among the other fish species examined for infestation and seasonal variation of Acanthocephalus ranae over three year period. The higher prevalence of infested fishes Caranx ignobilis (61.8% ±1.8), Seriolina nigrofasciata (48.6% ±1.3) and Dayseiaena albida (38.5% ±1.8) were observed. Mean intensities ranged between 5.8 and 12.6 worms per fish. Grossly, the parasites attached tissues were wounded, reddish, swollen, abraded and thickened. Histologically, the infested intestinal outer wall of the muscularies extema and tip of the proboscis is still inverted; Hyperplasia of the intestinal villi and lamina propria near the site of parasitic attachment were also evidenced. Cellular infiltrated area surrounding the proboscis, aggregation of lymphocytes and fibroblasts at the site of inflammation were observed from the parasitized intestine. The lesions were infiltrating with basophil-like inflammatory cells. The histological findings revealed that the pathological injure was depends on the density of the parasitic burden and depth of the proboscis penetration into the host intestine. Long live parasite increases the cellular infiltration and it may leads to the tumorous conditions of the infested hosts.
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