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2007 | 30 | 6 | 530-536
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A global survey of antibiotic leftovers in the outpatient setting

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We performed a global survey of outpatients who had taken self-administered antibiotics within the last 12 months in order to identify factors that lead to possession of leftover antibiotics in the community. The study included 4514 subjects aged 18–99 years. Of 4192 respondents not currently taking antibiotics, 53.7% admitted having leftover antibiotics, of whom 77.0% saved them, 4.6% gave them away and 18.4% threw them away. Living in a country where antibiotics are dispensed in fixed packs rather than exact numbers of pills as well as believing that leftover antibiotics can be saved and used again were the strongest predictors for possession of leftovers. There was also a marked detrimental effect of lack of information from the doctor and/or pharmacist. This investigation suggests that dispensing of antibiotics in exact numbers of doses should be recommended in addition to the development of relevant information campaigns addressing patients’ false beliefs about leftovers and the provision of basic information about the importance of completing antibiotic treatment.
Opis fizyczny
  • The First Department of Family Medicine, Medical University of Lodz, Narutowicza St. 96, Lodz, Poland ,
  • Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland
  • Centre for Economics and Policy in Health, University of Wales, IMSCaR, Dean Street, Bangor, Gwynedd LL57 1UT, UK
  • Department of Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
  • 1. Kardas, P.& Devine, S.& Golembesky, A.& Roberts, C., "A systematic review and meta-analysis of misuse of antibiotic therapies in the community", Int J Antimicrob Agents, vol. 26, 2005, p.106-113
  • 2. Ceaser, S.& Wurtz, R., "‘Leftover’ antibiotics in the medicine cabinet", Ann Intern Med, vol. 133, 2000, p.74
  • 3. Pechère, J.C.& Hughes, D.& Kardas, P.& Cornaglia, G., "Non-compliance with antibiotic therapy for acute community infections: a global survey", Int J Antimicrob Agents, vol. 29, 2007, p.245-253
  • 4. Dolan, P., "Modeling valuations for EuroQol health states", Med Care, vol. 35, 1997, p.1095-1108
  • 5. Kind, P., "The EuroQol instrument: an index of health-related quality of life", Spilker, B. (Eds.), Quality of life and pharmacoeconomics in clinical trials., 1996, 2nd ed., p.191-201
  • 6. Hosmer, D.W.& Lemeshow, S., "Applied logistic regression", 2000, 2nd ed.
  • 7. DeMaris, A., "Regression with social data: modeling continuous and limited response variables", 2004
  • 8. Carey, B.& Cryan, B., "Antibiotic misuse in the community—a contributor to resistance?", Ir Med J, vol. 96, 2003, p.43-44
  • 9. Okumura, J.& Wakai, S.& Umenai, T., "Drug utilisation and self-medication in rural communities in Vietnam", Soc Sci Med, vol. 54, 2002, p.1875-1886
  • 10. Parimi, N.& Pinto Pereira, L.M.& Prabhakar, P., "The general public's perceptions and use of antimicrobials in Trinidad and Tobago", Rev Panam Salud Publica, vol. 12, 2002, p.11-18
  • 11. Richman, P.B.& Garra, G.& Eskin, B.& Nashed, A.H.& Cody, R., "Oral antibiotic use without consulting a physician: a survey of ED patients", Am J Emerg Med, vol. 19, 2001, p.57-60
  • 12. Marliere, G.L.& Ferraz, M.B.& dos Santos, J.Q., "Antibiotic consumption patterns and drug leftovers in 6000 Brazilian households", Adv Ther, vol. 17, 2000, p.32-44
  • 13. Amare, G.& Gedif, T.& Alemayehu, T.& Tesfahun, B., "Pattern of drug use in Addis Ababa community", East Afr Med J, vol. 74, 1997, p.362-367
  • 14. Mitsi, G.& Jelastopulu, E.& Basiaris, H.& Skoutelis, A.& Gogos, C., "Patterns of antibiotic use among adults and parents in the community: a questionnaire-based study in a Greek urban population", Int J Antimicrob Agents, vol. 25, 2005, p.439-443
  • 15. Branthwaite, A.& Pechère, J.C., "Pan-European survey of patients’ attitudes to antibiotics and antibiotic use", J Int Med Res, vol. 24, 1996, p.229-238
  • 16. Pechère, J.C., "Patients’ interviews and misuse of antibiotics", Clin Infect Dis, vol. 33, Suppl. 3, 2001, p.S174-S179
  • 17. Grigoryan, L.& Haaijer-Ruskamp, F.M.& Burgerhof, J.G.M. et al., "Self-medication with antimicrobial drugs in Europe", Emerg Infect Dis, vol. 12, 2006, p.452-459
  • 18. McNulty, C.A.M.& Boyle, P.& Nichols, T.& Clappison, P.& Davey, P., "Antimicrobial drugs in the home", United Kingdom. Emerg Infect Dis, vol. 12, 2006, p.1523-1526
  • 19. Stratchounski, L.S.& Andreeva, I.V.& Ratchina, S.A. et al., "The inventory of antibiotics in Russian home medicine cabinets", Clin Infect Dis, vol. 37, 2003, p.498-505
  • 20. Adu-Sarkodie, Y.A., "Antimicrobial self-medication in patients attending a sexually transmitted diseases clinic", Int J STD AIDS, vol. 8, 1997, p.456-458
  • 21. Li, L.J.& Wang, P.S., "Self-medication with antibiotics: a possible cause of bacterial resistance", Med Hypotheses, vol. 65, 2005, p.1000-1001
  • 22. Mispagel, H.& Gray, J.T., "Antibiotic resistance from wastewater oxidation ponds", Water Environ Res, vol. 77, 2005, p.2996-3002
  • 23. Leftover drugs pose prescription for trouble. Few programs exist for environmentally safe drug disposal. Flushing them is no-no. Harv Heart Lett 2006; 16:6.
  • 24. Gordon, E.M.& Blumer, J.L., "Rationale for single and high dose treatment regimens with azithromycin", Pediatr Infect Dis J, vol. 23, Suppl., 2004, p.S102-S107
  • 25. McKee, M.D.& Mills, L.& Mainous III, A.G., "Antibiotic use for the treatment of upper respiratory infections in a diverse community", J Fam Pract, vol. 48, 1999, p.993-996
  • 26. Larson, E.& Grullon-Figueroa, L., "Availability of antibiotics without prescription in New York City", J Urban Health, vol. 81, 2004, p.498-504
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