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2018 | Vol. 9, no. 2 | 65--74
Tytuł artykułu

Dwa oblicza selenu. Wybrane aspekty aktywności biologicznej selenu

Treść / Zawartość
Warianty tytułu
Two faces of selenium. Selected aspects of selenium biological activity
Języki publikacji
Badania ostatnich lat wskazują na bardzo cenne pod względem medycznym właściwości selenu. Zainteresowanie selenem wzrosło odkąd poznano metody jego oznaczania w materiale biologicznym i jego rolę w organizmach żywych. Selen w zależności od stężenia wykazuje właściwości antyoksydacyjne i prooksydacyjne. Ponadto w badaniach na zwierzętach oraz ludzkich i zwierzęcych liniach komórkowych wykazuje właściwości antynowotworowe. W dobie wzrostu zachorowalności na choroby nowotworowe, selen cieszy się dużym zainteresowaniem naukowców na całym świecie. Obecne wyniki badań wskazują na bardzo różnorodną aktywność biologiczną selenu. Jednym z głównych mechanizmów działania tego pierwiastka jest czynny udział w ochronie komórek przed skutkami stresu oksydacyjnego. W prezentowanej pracy przeglądowej omówiono ogólne właściwości selenu, zaprezentowano jego aktywność biologiczną i obecny stan wiedzy o jego potencjalnym działaniu antynowotworowym. Przedstawiono mechanizmy działania selenu na poziomie molekularnym.
Studies of recent years indicate the very valuable properties of selenium in medical field. The interest in selenium has increased since we learned the methods of its determination in biological samples and its role in living organisms. Selenium, depending on the concentration, has antioxidant and prooxidative properties. In addition, in animal studies and human and animal cell lines, it exhibits anti-cancer properties. In the era of increased incidence of human and animal cancer, selenium is very popular among scientists around the world due to its high biological activity. Current research results highlight the various effects of selenium molecular activity. One of the main mechanisms of action of this element is active participation in the protection of cells against the effects of oxidative stress. The review presents the general properties of selenium, its biological activity and the current state of knowledge about its potential anticancer activity. Also, known molecular mechanisms of selenium activity in a living cell are mentioned.

Opis fizyczny
Bibliogr. 96 poz., rys., tab.
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Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW
przeznaczonych na działalność upowszechniającą naukę (2019).
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