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2012 | Vol. 3, no. 4 | 9--13
Tytuł artykułu

Functionalization of polyurethane surfaces for further attachment of bioactive molecules

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The challenge for cardiovascular tissue engineers is to design hemocompatible biomaterials that promote neo-tissue formation. Cardiovascular implants are prone to occlusion caused by surface thrombogenicity. In native tissue non-thrombogenic surface is provided by the endothelium. Endothelialization of implantable cardiovascular devices is thereby among the techniques of functionalizing biomaterials. Surfaces covered with peptides have been shown to enhance endothelial cells adhesion and proliferation. For the purpose of further cell-specifi c peptides immobilization, a three-step method for incorporating carboxyl groups onto a polyurethane surface was developed. In the fi rst step silanol groups were incorporated into the polyurethane surface. Successful reaction was proven by FTIR analysis. Subsequently, incorporation of surface amine groups was proceeded. In the last step amine groups were acylated using glutaric anhydride to create carboxylates. To determine the presence of surface functional groups, colorimetric method was applied. Measurement of water contact angle revealed signifi cant increase in surface hydrophilicity.
Wydawca

Rocznik
Strony
9--13
Opis fizyczny
Bibliogr. 21 poz., wykr., rys.
Twórcy
autor
autor
  • Warsaw University of Technology, Faculty of Chemical and Process Engineering, Warynskiego 1, 00-645 Warszawa, b.butruk@ichip.pw.edu.pl
autor
Bibliografia
  • [1] Ikada, Y. Tissue Engineering: Fundamentals and Application. Suzuka, Elsevier, 2006.
  • [2] Bruckner-Tuderman, L. et al. “Cell interactions with the extracellular matrix”. Cell and tissue research 339 (2010): 1–5.
  • [3] Venkatraman, S., F. Boey, and L.L. Lao. “Implanted cardiovascular polymers: Natural, synthetic and bio-inspired”. Progress in Polymer Science 33 (2008): 853–874.
  • [4] L’Heureux, N., et al. “Technology insight: the evolution of tissue-engineered vascular grafts-from research to clinical practice”. Nature Clinical Practice. Cardiovascular Medicine 4 (2007): 389–395.
  • [5] Vermette, P., et al. Biomedical Applications of Polyurethanes. Texas: Landes Bioscience-Eurekah.com Publishers, 2001.
  • [6] Wu, H.C., et al. “Coculture of endothelial and smooth muscle cells an a collagen membrane in the development of a small-diameter vascular grafts”. Biomaterials 28 (2007): 1385–1392.
  • [7] Sreerekha, P.R., and L.K. Krishnan. “Cultivation of endothelial progenitor cells on fi brin matrix and layering on Dacron®/polytetrafl uoroethylene vascular grafts”. Artifi cial organs 30 (2006): 242–249.
  • [8] Hersel, U., C. Dahmen, and H. Kessler. “RGD modifi ed polymers: biomaterials for stimulated cell adhesion and beyond”. Biomaterials 24 (2003): 4385–4415.
  • [9] Choi, W.S., et al. “Fabrication of endothelial cell-specific polyurethane surfaces co-immobilized with GRGDS and YIGSR peptides”. Macromolecular Research 7 (2009): 458–463.
  • [10] Massia, S.P., and J.A. Hubbell. “Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fi bronectin is mediated by integrin alfa4beta1”. The Journal of Biological Chemistry 20 (1992): 14019–14026.
  • [11] Wei, Y. et al. “Diff erent complex surface of polyethyleneglycol (PEG) and REDV ligand to enhance the endothelial cells selectivity over smooth muszle cells”. Colloids and Surfaces B: Biointerfaces 2 (2011):369–378.
  • [12] Goddard, J.M., and J.H. Hotchkiss. “Polymer surfach modifi cation for the attachment of bioactive compounds”. Progress in Polymer Science 32 (2007): 698–725.
  • [13] Vermette, P., et al. Biomedical Applications of Polyurethanes. Georgetown, EUREKACH.COM, 2001.
  • [14] Hasirci, N., and E.A. Ayse Aksoy. “Synthesis and Modifi cations of Polyurethanes for Biomedical Purposes”. High Performance Polymers 19 (2007): 621–637.
  • [15] Webb, K., V. Hlady, and P.A. Tresco. “Relative importance of surface wettability and charged functional groups on NIH 3T3 fi broblast attachment, spreading, and cytoskeletal organization”. Journal of Biomedical Materiale Research 3 (1998): 422–430.
  • [16] van Wachem, P. B., et al. “Interaction of cultured human endothelial cells with polymeric surfaces of diff erent wettabilities”. Biomaterials 6 (1985): 403–408.
  • [17] Arima, Y., and H. Iwata. “Eff ect of wettability and surfach functional groups on proteinadsorption and cell adhesion using well-defi ned mixed self-assembled monolayers”. Biomaterials 20 (2007): 3074–3082.
  • [18] Thevenot, P., W. Hu, and L. Tang. “Surface chemistry infl uence implant biocompatibility”. Current Topics in Medicinal Chemistry 8 (2008): 270–280.
  • [19] Ratner, B.D., et al. Biomaterials Science: An Introduction to Materials in Medicine. Elsevier Inc, 2004.
  • [20] Yu, Q., et al. “Anti-fouling bioactive surfaces”. Acta Biomaterialia 7 (2011): 1550–1557.
  • [21] Thevenot, P., W. Hu, and L. Tang. “Surface chemistry infl uence implant biocompatibility”. Current Topics in Medicinal Chemistry 8 (2008): 270–280.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.baztech-38e9890d-b1fe-4408-a7a9-73670e8cd748
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