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2015 | 64 | 1 |
Tytuł artykułu

Virus like particles as immunogens and universal nanocarriers

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Over the last two decades virus-like particles (VLPs) have become an important tool in biomedical research and medicine. VLPs are multi- protein structures that resemble viable virus particles in conformation but lack the viral genome. Consequently, they are non-infectious and non-replicative, but retain the ability to penetrate cells, making them useful for a vast spectrum of applications. Above all, VLPs mimicking genuine viruses in antigenic structure provide a safe alternative to attenuated and inactivated viruses in vaccine development. Moreover, due to their transducing proprieties, VLPs may efficiently deliver foreign nucleic acids, proteins, or conjugated compounds to the organism, or even to specific cell types. Additionally, VLPs are versatile nanovectors due to their flexibility in terms of composition and expression systems. In this review, different approaches for of virus-like particle synthesis and manipulation, as well as their potential applications, will be discussed.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
64
Numer
1
Opis fizyczny
p.3-13,fig.,ref.
Twórcy
autor
  • Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland
autor
  • Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland
  • Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
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