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2015 | 64 | 1 |
Tytuł artykułu

Effect of antibiotics on polymorphonuclear leukocyte functions and myeloperoxidase activity, glutathione and malondialdehyde levels in allergic asthma

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We investigated the effect of ciprofloxacin, rifampicine and doxycycline on myeloperoxidase (MPO) activity, glutathione (GSH) and malondialdehyde (MDA) levels in allergic asthma patients and healthy volunteers. Polymorphonuclear leukocytes(PMNs) were isolated with ficoll-hypaque gradient centrifugation method. MPO activity was assayed with modified o-dianisidine, GSH by Ellman’s and MDA levels by Beuge’s method. PMN functions and MDA levels of patients significantly decreased when compared with healthy volunteers. Ciprofloxacin significantly increased PMN functions, MPO activity and MDA levels of both groups. We have demonstrated that ciprofloxacin has beneficial effects on MPO activity and PMN functions in allergic asthma patients and healthy volunteers.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
64
Numer
1
Opis fizyczny
p.69-72,ref.
Twórcy
autor
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Haydarpasa-Istanbul, Turkey
autor
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Haydarpasa-Istanbul, Turkey
autor
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Haydarpasa-Istanbul, Turkey
autor
  • Department of Internal Medicine, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
autor
  • Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpasa-Istanbul, Turkey
autor
  • Department of Pneumonology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
autor
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Haydarpasa-Istanbul, Turkey
Bibliografia
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  • Beuge J.A. and S.D. Aust. 1978. Microsomal lipid peroxidation, Meth. Enzymol. 52: 302–311.
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Typ dokumentu
Bibliografia
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