Nowa wersja platformy jest już dostępna.
Przejdź na https://bibliotekanauki.pl

PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 34 | 6 |
Tytuł artykułu

Influence of organic supplements on accumulation of beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid in callus culture of Boswellia serrata Roxb.

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Boswellia serrata Roxb. is a source of several bioactive triterpenoids. Boswellic acid, obtained from oleogum resin of the tree, is a major potentially bioactive and medicinal compound. Unrestricted exploitation of its natural resource has led to its listing among the threatened and endangered species. Accumulation of the compound through tissue culture seems a promising option. The present work was conducted to study the effect of sodium pyruvate, L-phenylalanine, glycine, ferulic acid and sucrose on the growth of callus and accumulation of four principal isomers of boswellic acids, viz. β-boswellic acid (BBA), acetyl-β-boswellic acid (ABBA), 11-keto-β-boswellic acid (KBBA) and acety1⁻¹1-keto-β-boswellic acid (AKBBA). Callus cultures obtained from embryo explants of Boswellia serrata on Murashige and Skoog medium containing 2.5 µM 6-benzyladenine, 15 µM indole acetic acid and 200 mg 1⁻¹ polyvinyl pyrrolidone was supplemented with varying concentrations of the supplements. Sodium pyruvate was most beneficial for the production of AKBBA (77 folds), BBA (27 folds) and ABBA (27 folds) at 10 mg 1⁻¹ and for KBBA (47 folds) at 5 mg 1⁻¹ when compared with control. It was closely followed by sucrose (50 g 1⁻¹) resulting in KBBA (22-fold), AKBBA (25-fold), BBA (17-fold) and ABBA (10-fold). Glycine, L-phenylalanine and ferulic acid were relatively less effective. It can be concluded that callus cultures manipulated with different concentrations of organic supplements, sodium pyruvate or sucrose, in particular, could be considered as an alternate strategy for direct production of boswellic acid and help in the conservation of the species.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
34
Numer
6
Opis fizyczny
p.2275-2283,fig.,ref.
Twórcy
autor
  • Center for Rheumatic Diseases, 11 Hermes Elegance, 1988 Convent Street, Camp, 411001 Pune, India
  • Department of Botany, University of Pune, 411007 Pune, India
autor
  • Center for Rheumatic Diseases, 11 Hermes Elegance, 1988 Convent Street, Camp, 411001 Pune, India
autor
  • Department of Botany, University of Pune, 411007 Pune, India
Bibliografia
  • Aharoni A, Jongsma MA, Bouwmeester HJ (2005) Volatile science? Metabolic engineering of terpenoids in plants. Trends Int Plant Sci 10:594–602
  • Aharoni A, Jongsma MA, Kim TY, Ri MB, Giri AP, Verstappen FWA, Schwab W, Bouwmeester HJ (2006) Metabolic engineering of terpenoid biosynthesis in plants. Phytochem Rev 5:49–58
  • Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, Stephanopoulos G (2008) Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol Pharm 5(2):167–190
  • Ammon HP (2006) Boswellic acids in chronic inflammatory diseases. Planta Med 72:1100–1116
  • Chakraborty A, Chattopadhyay S (2008) Stimulation of menthol production in Mentha piperita cell culture. In Vitro Cell Dev Biol Plant 44:518–524
  • Chappell J (2002) The genetics and molecular genetics of terpene and sterol origami. Curr Opin Plant Biol 5:151–157
  • Christen P, Aoki T, Shimomura K (1992) Characteristic of growth and tropane alkaloid production in Hyoscynaus albus hairy roots transformed with Agrobactrium rhizogenenes A4. Plant Cell Rep 11:597–600
  • Cody GD, Boctor NZ, Filley TR, Hazen RM, Scott JM, Sharma A, Yoder HS (2000) Primordial carbonylated iron–sulfur compounds and the synthesis of pyruvate. Science 289:1337–1340
  • Cresswell RC, Fowler MW, Stafford A, Sarkissian GS (1989) Input and output: primary substrates and secondary metabolism. In: Kurz WGW (ed) Primary and secondary metabolism of plant cell culture II. Springer, Berlin, pp 14–26
  • Dessouky MM, Taha HS, El-Bahr MK (2001) Enhancement of alkaloid production in suspension cultures of Datura stramonium L. and Datura metel L. Arab. J Biotechnol 4(2):271–272
  • Elfahmi SB, Albert K, Thomas H, Rein B, Oliver K, Herman JW, Wim JQ (2006) Lignans from cell suspension cultures of Phyllanthus niruri, an Indonesian medicinal plant. J Nat Prod 69:55–58
  • Fett-Neto AG, Melanson SJ, Nicholson SA, Pennington JJ, Di Cosmo F (1994) Improved taxol yield by aromatic carboxylic and amino acid feeding to cell cultures of Taxus cuspidata. Biotechnol Bioeng 44:967–971
  • Furmanowa M, Oledzka H, Syklowka-Baranek K, Jozefowicz J, Gieracka S (2000) Increased taxane accumulation in callus cultures of Taxus cuspidata and Taxus media by some elicitors and precursors. Biotechnol Lett 22:1449–1452
  • Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirements of suspensions cultures of soybean root cells. Exp Cell Res 50:151–158
  • Gao M, Zhang W, Yue X, Xiao H (2010) Production of two intermediate taxoids, 2-hydroxy-5α, 10β-diacetoxytaxadiene and 2-hydroxy-5α, 10β, 14 β-triacetoxytaxadiene, from Taxus chinensis cell culture. Afri J Biotechnol 9(49):8486–8491
  • Gayathri B, Manjula N, Vinaykumar KS, Lakshmi BS, Balakrishnan A (2007) Pure compound from Boswellia serrata extract exhibit anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNF alpha, IL-1 beta, NO and MAP kinases. Int Immunopharmacol 7(4):473–482
  • Ghorpade RP, Chopra A, Nikam TD (2010) In vitro zygotic embryo germination and propagation of an endangered Boswellia serrata Roxb., a source of boswellic acid. Physiol Mol Biol Plant 16(2):159–165
  • Haq N (2005) In vitro production of bioactive compounds from medicinal and aromatic plants. In: Tele Medicine Pakistan Agriculture, pp 1–27
  • Kang SM, Jung HY, Kang YM, Min JY, Karigar CS, Yang JK, Kim SW, Ha YR, Lee SH, Choi MS (2005) Biotransformation and impact of ferulic acid on phenylpropanoid and capsaicin levels in Capsicum annuum L. cv. P1482 cell suspension cultures. J Agric Food Chem 53:3449–3453
  • Karam NS, Jawad FM, Arikat NA, Shibi RA (2003) Growth and rosmarinic acid accumulation in callus, cell suspension, and root cultures of wild Salvia fruticosa. Plant Cell Tissue Org Cult 73:117–121
  • Kiong ALP, Mahmood M, Fadzillah NM, Daud SK (2005) Effect of precursor supplementation on the production of triterpenes by Centella asiatica callus cultures. Pak J Biol Sci 8(8):1160–1169
  • Knobloch KH, Berlin J (1990) Influence of medium composition on formation of secondary compound in cell suspension cultures of Catharanthus roseus L. G Don Z Naturforsch 35C:551–556
  • Krüger P, Kanzer J, Hummel J, Fricker G, Schubert-Zsilavecz M, Abdel-Tawab M (2009) Permeation of Boswellia extract in the Caco-2 model and possible interaction of its constituent KBBA and AKBBA with OATP1B3 and MRP2. Eur J Pharm Sci 36(2–3):275–284
  • Lindsey K, Yeoman MM (1984) The synthetic potential of immobilized cells of Capsicum frutescens Mill. cv. annuum. Planta 162:495–501
  • Lücker J, Bouwmeester HJ, Aharoni A (2007) Metabolic engineering of terpenoid biosynthesis in plants. In: Verpoorte R et al. (eds) Applications of plant metabolic engineering. Springer, Berlin, pp 219–236
  • Majumder A, Jha S (2009) Biotechnological approaches for the production of potential anticancer leads podophyllotoxin and paclitaxel: an overview. J Biol Sci 1(1):46–69
  • Malarz J, Stojakowska A, Kisiel W (2007) Effect of methyl jasmonate and salicylic acid on sesquiterpene lactone accumulation in hairy roots of Cichorium intybus. Acta Physiol Plant 29:127–132
  • Mantell SH, Pearson DW, Hazell LP, Smith H (1983) The effect of initial phosphate and sucrose levels on nicotine accumulation in batch suspension cultures of Nicotiana tobacum L. Plant Cell Rep 2:73–77
  • Mulabagal V, Tsay HS (2004) Plant cell cultures—an alternative and efficient source for the production of biologically important secondary metabolites. Int J Appl Sci Eng 2(1):29–48
  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–479
  • Parale A, Barmukh R, Nikam T (2010) Influence of organic supplements on production of shoot and callus biomass and accumulation of bacoside in Bacopa monniera (L.) Pennell. Physiol Mol Biol Plants 16(2):167–175
  • Pardhy RS, Bhattacharyya SC (1978a) Structure of serratol, a new diterpene cembranoid alcohol from Boswellia serrata Roxb. Ind J Chem 16B:171–173
  • Pardhy RS, Bhattacharyya SC (1978b) β-Boswellic acid, acetylboswellic acid and 11-ketoboswellic acid, four pentacyclic triterpenic acids from the resin of Boswellia serrata Roxb. Ind J Chem 16B:176–178
  • Pardhy RS, Bhattacharyya SC (1978c) Tetracylic triterpenic acids from the resin of Boswellia serrata Roxb. Ind J Chem 16B:174–175
  • Purohit SD, Tak K, Kukda G (1995) In vitro propagation of Boswellia serrata Roxb. Biol Plantarum 37(3):335–340
  • Rao SR, Ravishankar GA (2002) Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv 20:101–153
  • Robert TT, Dennis JG (2000) Plant tissue culture concept and laboratory exercises, 2nd edn. CRC Press, London, pp 81–97
  • Roberts SC (2007) Production and engineering of terpenoids in plant cell culture. Nat Chem Biol 3(7):387–395
  • Sakamoto K, Iida K, Sawamura K, Hajiro K, Asada Y, Yoshikawa T, Furuya T (1993) Effects of nutrients on anthocyanin production in cultured cells of Aralia cordata. Phytochemicals 33:357–360
  • Salonen ML, Simola LK (1977) Dipeptides and amino acids as nitrogen sources for the callus of Atropa belladonna. Physiol Plant 41:55–58
  • Shah SA, Rathod IS, Suhagia BN, Pandya SS, Parmar VK (2008) A simple high-performance liquid chromatography for the estimation of boswellic acids from the market formulations containing Boswellia serrata extract. J Chrom Sci 46(8):735–738
  • Shah BA, Qazi GN, Taneja SC (2009) Boswellic acids a group of medicinally important compounds. Nat Prod Rep 26:72–89
  • Sharma S (1983) A census of rare and endemic flora of South-East Rajasthan. In: Jain SK, Rao RR (eds) Threatened plants of India. Botanical Survey of India, Howrah, pp 630–670
  • Sherif FE (2004) Effect of some precursors on development of secondary products in tissues and media of embryogenic callus of date palm cv. Sewi Arab J Biotechnol 7(1):83–90
  • Sudhakar JT, Ravishankar GA, Venkataraman LV (1996) Biotransformation of ferulic acid and vanillylamine to capsaicin and vanillin in immobilized cell cultures of Capsicum frutescens. Plant Cell Tissue Org Cult 44:117–121
  • Van Uden W, Pras N, Malingré TM (1990) On improvement of the podophyllotoxin production by phenyl-propanoid precursor feeding to cell cultures of Podophyllum hexandrum Royle. Plant Cell Tissue Org Cult 23:217–224
  • Weilkanek M, Urbanek H (2006) Enhanced glucotropaeolin production in hairy root cultures of Tropaeloum majus L. by combining elicitation and precursor feeding. Plant Cell Tissue Org Cult 86:177–186
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-d2766992-0d2f-4715-bfce-180b2a1a0976
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.