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2004 | 49 | 3 |
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Rodent interleukins - their molecular characteristics and a role in immunological responses against parasitic infections

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Języki publikacji
Interleukins play a very important regulatory role in the immunological system. Much attention is payed to understand their complicated activities during parasite infections. To investigate their presence in host organisms techniques of molecular biology have been applied. Nucleotide sequences of many interleukins have been established and analysed. The coding sequences of different species are highly conserved. Rodents are especially investigated because of their usefulness as laboratory models for many animal and human parasitic diseases. Here we take a look at mouse (Mus musculus), rat (Rattus norvegicus), hamster (Mesocricetus auratus) and guinea pig (Cavia porcellus) interleukins and compare their coding sequences and gene structures.
Opis fizyczny
  • Department of Parasitology, Faculty of Veterinary Medicine, Warsaw Agriculture University, 8 Ciszewskiego Street, 02-786 Warsaw, Poland
  • Department of Parasitology, Faculty of Veterinary Medicine, Warsaw Agriculture University, 8 Ciszewskiego Street, 02-786 Warsaw, Poland
  • Department of Molecular Biology, W. Stefański Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda Street, 00-818 Warsaw, Poland
  • Cetre C., Pierrot C., Cocude C., Lafitte S., Capron A., Capron M., Khalife J. 1999. Profiles of Th1 and Th2 cytokines after primary and secondary infection by Schistosoma mansoni in the semipermissive rat host. Infection and Immunity, 67, 2713- 2719.
  • Corpet F. 1988. Multiple sequence alignment with hierarchical clustering. Nucleic Acids Research, 16, 10881-10890.
  • Crutcher J.M., Stevenson M.M., Sedegah M., Hoffman S.L. 1995. Interleukin 12 and malaria. Research in Immunology, 146, 552-559.
  • Del Prete G., De Carli M., Almerigogna F., Guidizi M.G., Biagiotti R., Romangnani S. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. Journal of Immunology, 150, 353-360.
  • De Wall Malefyt R., Abrams J., Bennett B., Figdor C., De Vires J. 1991. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. Journal of Experimental Medicine, 174, 1209-1218.
  • Else K.J., Finkelman F.D. 1998. Intestinal nematode parasites, cytokines and effector mechanisms. International Journal for Parasitology, 28, 1145-1158.
  • Fiorentino D.F., Zlotnik A., Mosmann T.R., Howard M.H., O’Garra A. 1991. IL-10 inhibits cytokine production by activated macrophages. Journal of Immunology, 147, 3815-3821.
  • Fuse A., Fujita T, Yasumitsu H., Kashima N., Hasegawa K., Taniguchi T. 1984. Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Research, 12, 9323-9331.
  • Goto H., Lindoso J.A.L. 2004. Immunity and immunosuppression in experimental visceral leishmaniasis. Brazilian Journal of Medical and Biological Research, 37, 615-623.
  • Grimm E.A. 2000. Cytokines: Biology and applications in cancer medicine. Cancer Medicine, 5, 825-834.
  • Helmby H., Grencis R.K. 2003. Contrasting roles for IL-10 in protective immunity to different life stages of intestinal nematode parasites. European Journal of Immunology, 33, 2382- 2390.
  • Kaliński P., Vieira P.L., Schuitemaker J.H.N., de Jong E.C., Kapsenberg M.L. 2001. Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12 p40) production and inhibitor of bioactive IL-12 p70 heterodimer. Blood, 97, 3466-3469.
  • Kim J.M., Brannan C.I., Copeland N.G., Jenkins N.A., Khan T.A., Moore K.W. 1992. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. Journal of Immunology, 148, 3618-3623.
  • Kobayashi M., Fitz L., Ryan M., Hewick R.M., Clark S.C., Chan S., Loudon R., Sherman F., Perussia B., Trinchieri G. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. Journal of Experimental Medicine, 170, 845-872.
  • Lamont A.G., Adorini L. 1996. IL-12: a key cytokine in immune regulation. Immunology Today, 17, 214-217.
  • Luty A.J., Perkins D.J., Leli B., Schmidt-Ott R., Lehman L.G., Luckner D., Greve B., Matousek P., Herbich K., Schmid D.J., Weinberg B., Kremsner P.G. 2000. Low interleukin 12 activity in severe Plasmodium falciparum malaria. Infection and Immunity, 68, 3909-3915.
  • Malaguamera L., Musumeci S. 2002. The immune response to Plasmodium falciparum malaria. Lancet Infectious Diseases, 2, 472-478.
  • Malek T.R. 2003. The main function of IL-2 is to promote the development of T regulatory cells. Journal of Leukocyte Biology, 74, 961-965.
  • Manetti R., Gerosa F., Giudizi M.G., Biagiotti R., Parrouchi P., Piccinni P., Sampognaros S., Maggi E., Romagnani S., Trinchieri G. 1994. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. Journal of Experimental Medicine, 179, 1273-1283.
  • Maruyama K., Takigawa Y., Akiyama Y., Hojo T., Nara-Ashizawa N., Cheng J., Watanabe M., Yamaguchi K. 2003. Structure and characterization of hamster IL-12 p35 and p40. Molecular Immunology, 40, 319-326.
  • Melby P.C., Tryon V.V., Chandrasekar B., Freeman G.L. 1998. Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis. Infection and Immunity, 66, 2135-2142.
  • Morgan D.A., Ruscetti F.W., Gallo R.G. 1976. Selective in vitro growth of T-lymphocytes from normal bone marrows. Science, 193, 1007-1008.
  • Otsuka T., Villaret D., Yokota T., Takebe Y, Lee F., Arai N., Arai K. 1987. Structural analysis of the mouse chromosomal gene encoding interleukin 4 which express B cell, T cell and mast cell stimulating activities. Nucleic Acids Research, 15, 333— 344.
  • Paul W.E., Seder R.A. 1994. Lymphocyte responses and cytokines. Cell, 76, 241-251.
  • Scharton-Kerston T., Afonso L.C.C., Wysocka M., Trinchieri G., Scott P. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. Journal of Immunology, 154, 5320— 5330.
  • Shiratori I., Matsumoto M., Tsuji S., Nomura M., Toyoshima K., Seya T. 2001. Molecular cloning and functional characterization of guinea pig IL-12. International Immunology, 13, 1129-1139.
  • Swain S.L., Weinberg A.D., English M., Huston G. 1990. IL-4 directs the development of Th2-like helper effectors. Journal of Immunology, 145, 3796-3806.
  • Trinchieri G. 1994. Interleukin-12: a cytokine produced by antigen- presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood, 84, 4008-4027.
  • Vieira P., De Waal Malefyt R., Dang M.N., Johnson K.E., Kastelein R., Fiorentino D.F., De Vries J.E., Roncarolo M.G., Mosmann T.R., Moore K.’V. 1991. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proceedings of National Academy of Sciences, USA, 88, 1172-1176.
  • Yoshimoto T., Kojima K., Funakoshi T., Endo Y., FujitaT., Nariuchi H. 1996. Molecular cloning and characterization of murine IL-12 genes. Journal of Immunology, 156, 1082-1088.
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