PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2002 | 49 | 3 |
Tytuł artykułu

Induction of the synthesis of an additional family of long-chain dolichols in the yeast Saccharomyces cerevisiae. Effect of starvation and ageing

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The yeast Saccharomyces cerevisiae strain W303 synthesizes in the early logarith­mic phase of growth dolichols of 14-18 isoprene residues. The analysis of the polyisoprenoids present in the stationary phase revealed an additional family which proved to be also dolichols but of 19-24 isoprene residues, constituting 39% of the to­tal dolichols. The transfer of early logarithmic phase cells to a starvation medium lacking glucose or nitrogen resulted in the synthesis of the longer chain dolichols. The additional family of dolichols represented 13.8% and 10.3% of total dolichols in the glucose and nitrogen deficient media, respectively. The level of dolichols in yeast cells increased with the age of the cultures. Since both families of dolichols are present in stationary phase cells we postulate that the longer chain dolichols may be responsi­ble for the physico-chemical changes in cellular membranes allowing yeast cells to adapt to nutrient deficient conditions to maintain long-term viability.
Wydawca
-
Rocznik
Tom
49
Numer
3
Opis fizyczny
p.781-787,fig.
Twórcy
  • Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland
autor
Bibliografia
  • Adams A, Gottschling D, Kaiser C, Stearns T. (1997) In Methods in yeast genetics. A Cold Spring Harbor Laboratory Course Manual. CSH Laboratory Press.
  • Chojnacki T, Dallner G. (1988) The biological role of dolichol. Biochem J.; 251: 1-9.
  • Gennis RB. (1989) Biomembranes. Molecular structure and function. Springer-Verlag. New York.
  • Herscovics A, Orlean P. (1993) Glycoprotein biosynthesis in yeast. FASEB J.; 7: 540-50.
  • Janas T, Walinska K, Chojnacki T, Swiezewska E, Janas T. (2001) Modulation of phospholipid membranes by the long- chain polyprenol (C160). Chem Phys Lipids.; 106: 31-40.
  • Klosgen B, Helfrich W. (1997) Cryo-transmission electron microscopy of a superstructure of fluid dioleoylphosphatidylcholine (DOPC) membranes. Biophys J.; 73: 3016-29.
  • Paton BC, Poulos AJ. (1984) Dolichol metabolism in cultured skin fibroblasts from patients with "neuronal" ceroid lipofuscinosis (Batten's disease). J. InheritMetab Dis.; 7: 112-6.
  • Pullarkat R, Reha H. (1982) Accumulation of dolichols in brains of elderly. J Biol Chem.; 257: 5991-3.
  • Sagami H, Kurisaki A, Ogura K. (1993) Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver. J Biol Chem.; 268: 10109-13.
  • Sagami H, Igarashi Y, Tateyama S. (1996) Enzymatic formation of dehydrodolichal and dolichal, new products related to yeast dolichol biosynthesis. J Biol Chem.; 271: 9560-6.
  • Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A. (1999) The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis. Mol Cell Biol.; 19: 471-83.
  • Sato M, Fujisaki S, Sato K, Nishimura Y, Nakano A. (2001) Yeast Saccharomyces cerevisiae has two cis- prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis. Genes Cells.; 6: 495-506.
  • Schenk B, Rush J, Waechter Ch, Aebi M. (2001) An alternative cis-prenyltransferase activity in yeast that produces polyisoprenols with chain lengths similar to mammalian dolichols. Glycobiology.; 11: 89-98.
  • Swiezewska E, Sasak W, Mankowski T, Jankowski W, Vogtman T, Krajewska I, Hertel J, Skoczylas E, Chojnacki T. (1994) The search for plant polyprenols. Acta Biochim Polon.; 41: 221-60.
  • Szkopinska A, Swiezewska E, Chojnacki T. (1992) On the specificity of dolichol kinase and DolPMan synthase towards isoprenoid alcohols of different chain length in rat liver microsomal membrane. Int J Biochem.; 24: 1151-17.
  • Valtersson C, van Duijn G, Verkleij A, Chojnacki T, de Kruijff B, Dallner G. (1985) The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes. J Biol Chem.; 260: 2742-51.
  • Van Duijn G, Valtersson C, Chojnacki T, Verkleij A, Dallner G, de Kruijff B. (1986) Dolichyl phosphate induces non- bilayer structures, vesicle fusion and transbilayer movement of lipid: a model membrane study. Biochim Biophys Acta.; 861: 211-23.
  • Werner-Washburne M, Braun E, Johnstone G, Singer R. (1993) Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev.; 57: 383-401.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-3fe6f9b0-89d9-41e4-bfad-131f563d0c33
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.