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1995 | 42 | 1 |
Tytuł artykułu

Immunotherapy in Gram-negative bacterial infections

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Endotoxins are responsible for initiation of septic shock which increases the number of fatalities in Gram-negative bacteremia among hospital patients. The morality from septic shock is still high despite recent developments in antibiotic therapy because antibiotics are unable to decrease the level of free lipopolysaccharide in the blood stream. Another approach to the treatment and prevention of septicaemia involves stimulation of an immune response against LPS. It was found that immunization with the core structures of endotoxin conjugated with proteins protected animals against infections and endotoxic shock. Anticonjugate sera are of great interest because they are directed against conserved parts of LPS and therefore could have cross-reactive and cross-protective properties with respect to many Gram-negative rods.
Wydawca
-
Rocznik
Tom
42
Numer
1
Opis fizyczny
p.19-24,fig.
Twórcy
autor
  • Polish Academy of Sciences, Czerska 12, 53-114 Wroclaw, Poland
Bibliografia
  • 1. Rietschel, E.T., Kirikae, T. & Schade, F.U. (1993) The chemical structure of bacterial endotoxin in relation to bioactivity. Immunobiology 187, 169-190.
  • 2. Rietschel, E.T. & Brade, H. (1992) Bacterial endotoxins. Sci. Amer. 267,54-61.
  • 3. Holst, O. & Brade, H. (1992) Chemical structure of the core region of lipopolysaccharides; in Molecular Biochemistry and Cellular Biology, Bacterial Endotoxic Lipopolysaccharides; vol. 1, pp. 133-170, CRC Press, Boca Raton.
  • 4. Dell, A., Oates, J., Ługowski, C, Romanowska, E., Kenne, L. & Lindberg, B. (1984) The Entero­bacterial Common-Antigen, a cyclic polysacch­aride. Carbohydr. Res. 133,95-104.
  • 5. Shenep, J., Flynn, F.H., Barret, F.F., Stidham, G.I. & Westenkirchner, D.F. (1988) Serial quanti­tation of endoloxemia and bacteremia during therapy for Gram-negative sepsis. /. Infect. Dis. 157, 567-568.
  • 6. Jennings, H.J., Ługowski, C. & Ashton, F.K. (1984) Conjugation of meningococcal lipopo- lysaccharide R-type oligosaccharides to tetanus toxoid as route to a potential vaccine against group B Neisseria meningitidis. Infect. Immiin. 43, 407-412.
  • 7. Ługowski, C., Kułakowska, M. & Romanowska, Ii. (1986) Characterization and diagnostic appli­cation of a iipopolysaccharide core oligosacch- aride-protein conjugate. J. Immunol. Methods 95, 187-194.
  • 8. Ługowski, C, Jachymek, W., Niedziela, 'I'. & Kwiecińska, E. (1994) Protective anti-core type Rl-tetanus toxoid conjugate serum binds to smooth lipopolysaccharides and smooth, alive bacterial cells. /. Endotoxin Res. 1 suppl. 90.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-article-233f3624-9d3f-4bc5-a4bc-32ee677ad935
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