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2009 | 69 | 4 |
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Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system

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The role of the opioid system in mediating effects of alcoholism and stress in depression is far from clear. We studied, therefore, the effects of chronic mild stress (CMS) and alcohol drinking on depression-like behavior and nociception in lines of mice selected for high (HA) or low (LA) swim stress-induced analgesia. Compared to the LA mice, the HA animals display up-regulation of opioid receptor system function and depression-like behavior in tail suspension test (TST). We report now that alcohol reverses depressive and pronociceptive effect of CMS in HA mice. In contrast, in LA mice CMS does not affect nociception or behavior in TST and the animals are not susceptible to alcohol under CMS. The results suggest that opioid system activity may determine the effects of alcohol on behavior under stress and, therefore, link predispositions to depression and to alcoholism.
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  • Department of Molecular Cytogenetic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland
  • Department of Animal Behaviour, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
  • Department of Pharmacology, Toxicology and Neuroscience, Shreveport, LA, USA
  • Department of Molecular Cytogenetic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland
  • Neuropeptide Laboratory, M.Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Department of Animal Behaviour, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Wolka Kosowska, Poland
  • Amir S (1982) Involvement of endogenous opioids with forced swimming-induced immobility in mice. Physiol Behav 28: 249-251. Barr CS, Schwandt ML, Newman TK, Higley JD (2004) The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychologi­cal variables. Ann N Y Acad Sci 1021: 221-233.
  • Campbell VC, Taylor RE, Tizabi Y (2006) Antinociceptive effects of alcohol and nicotine: involvement of the opioid system. Brain Res 1097: 71-77.
  • Campbell VC, Taylor RE, Tizabi Y (2007) Effects of selec­tive opioid receptor antagonists on alcohol-induced and nicotine-induced antinociception. Alcohol Clin Exp Res 31: 1435-1440.
  • Carlezon WA Jr, Béguin C, DiNieri JA, Baumann MH, Richards MR, Todtenkopf MS, Rothman RB, Ma Z, Lee DY, Cohen BM (2006) Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther 316: 440-447.
  • Casey KL, Dubner R (1989) Animal models of chronic pain: scientific and ethical issues. Pain 38: 249-252.
  • Dean AJ, Saunders JB, Jones RT, Young R.M, Connor JP, Lawford BR (2006) Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence. J Psychiatry Neurosci 31: 38-45.
  • Eschalier A, Fialip J, Varoguaux O, Makambila MC (1987) Study of the clomipramine-morphine interaction in the forced swimming test in mice. Psychopharmacology (Berl) 93: 515-519.
  • Extein IL, Gold MS (1993) Hypothesized neurochemical models for psychiatric syndromes in alcohol and drug dependence. J Addict Dis 12: 29-43.
  • Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gaveriaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25: 195-200.
  • Gordis E (1997) Genes and the environment in complex dis­eases: a focus on alcoholism. Mol Psychiatry 2: 282-286.
  • Heath AC, Todorov AA, Nelson EC, Madden PA, Bucholz KK, Martin NG (2002) Gene-environment interaction effects on behavioral variation and risk of complex disor­ders: the example of alcoholism and other psychiatric disorders. Twin Res 5: 30-37.
  • Jann MW, Slade JH (2007) Antidepressant agents for the treatment of chronic pain and depression. Pharmacotherapy 27: 1571-1587.
  • Juszczak GR, Sliwa AT, Wolak P, Tymosiak-Zielinska A, Lisowski P, Swiergiel AH (2006) The usage of video analysis system for detection of immobility in the tail suspension test in mice. Pharmacol Biochem Behav 85: 332-338.
  • Kest B, Mogil JS, Sternberg WF, Liebeskind JC, Sadowski B (1993) Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia. Proc West Pharmacol Soc 36: 249-253.
  • Kest B, Jenab S, Brodsky M, Sadowski B, Belknap JK, Mogil JS, Inturrisi CE (1999) Mu and delta opioid recep­tor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Res 816: 381-389.
  • Kompagne H, Bardos G, Szenasi G, Gacsalyi I, Harsing LG, Levay G (2008) Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav Brain Res 193: 311-314.
  • Kosten TR, Markou A, Koob GF (1998) Depression and stimulant dependence: neurobiology and pharmacothera­py. J Nerv Ment Dis 186: 737-745.
  • Langbehn DR, Cadoret RJ, Caspers K, Troughton EP, Yucuis R (2003) Genetic and environmental risk factors for the onset of drug use and problems in adoptees. Drug Alcohol Depend 69: 151-167.
  • Langford DJ, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS, Chanda ML, Levitin DJ, Mogil JS (2006) Social modulation of pain as evidence for empa­thy in mice. Science 312: 1967-1970.
  • Lautenbacher S, Roscher S, Strian D, Fassbender K, Krumrey K, Krieg JC (1994) Pain perception in depression: rela­tionships to symptomatology and naloxone-sensitive mechanisms. Psychosom Med 56: 345-352.
  • Lindholm S, Werme M, Brene S, Franck J (2001) The selec­tive kappa-opioid receptor agonist U50,488H attenuates voluntary alcohol intake in the rat. Behav Brain Res 120: 137-146.
  • Lutfy K, Sadowski B, Kwon IS, Weber E (1994) Morphine analgesia and tolerance in mice selectively bred for diver­gent swim stress-induced analgesia. Eur J Pharmacol 265: 171-174.
  • Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC Jr, Jones RM, Portoghese PS, Carlezon WA Jr (2003) Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther 305: 323-330.
  • Mangold DL, Peyrot M, Giggey P, Wand GS (2000) Endogenous opioid activity is associated with obsessive-compulsive symptomology in individuals with a family history of alco­holism. Neuropsychopharmacology 22: 595-607.
  • Mogil JS, Marek P, Yirmiya R, Balian H, Sadowski B, Taylor AN, Liebeskind JC (1993) Antagonism of the non-opioid component of alcohol-induced analgesia by the NMDA receptor antagonist MK-801. Brain Res 602: 126-130.
  • Mogil JS, Marek, P, O'Toole LA, Helms ML, Sadowski B, Liebeskind JC, Belknap JK (1994) Mu-opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia. Brain Res 653: 16-22.
  • Mogil JS, Kest B, Sadowski B, Belknap JK (1996) Differential genetic mediation of sensitivity to mor­phine in genetic models of opiate antinociception: influ­ence of nociceptive assay. J Pharmacol Exp Ther 276: 532-544.
  • Moreau JL, Jenck F, Martin JR, Mortas P, Haefely WE (1992) Antidepressant treatment prevents chronic unpre­dictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats. Eur Neuropsychopharmacol 2: 43-49.
  • Natan LB, Chaillet P, Lecornte JM, Marcais H, Uchida G, Costentin A (1984) Involvement of endogenous enkepha­lins in mouse 'behavioral despair' test. Eur J Pharmacol 97: 301-304.
  • Olgiati P, Liappas I, Malitas P, Piperi C, Colitis A, Tzavellas EO, Zisaki A, Ferrari B, De Ronchi D, Kalofoutis A, Serretti A (2007) Depression and social phobia secondary to alcohol dependence. Neuropsychobiology 56: 111­118.
  • Panocka I, Marek P, Sadowski B (1986a) Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding. Brain Res 397: 156-160.
  • Panocka I, Marek P, Sadowski B (1986b) Inheritance of stress-induced analgesia in mice. Selective breeding study. Brain Res 397: 152-155.
  • Panocka I, Marek P, Sadowski B (1991) Tolerance and cross-tolerance with morphine in mice selectively bred for high and low stress-induced analgesia. Pharmacol Biochem Behav 40: 283-286.
  • Panocka I, Massi M, Lapo I, Swiderski T, Kowalczyk M, Sadowski B (2001) Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity. Peptides 22: 1037-1042.
  • Pfeiffer A, Brantl V, Herz A, Erich HM (1986) Psychotomimesis mediated by kappa opiate receptors. Science 233: 774-776.
  • Preuss UW, Schuckit MA, Smith TL, Danko GR, Dasher AC, Hesselbrock MN, Hesselbrock VM, Nurnberger JI Jr (2002) A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attempts. J Stud Alcohol 63: 498-502.
  • Przewłocki R, Lasoń W, Majeed NH, Przewłocka B (1985) Antidepressants and endogenous opioid peptide systems. Neuropeptides 5: 575-578.
  • Sacharczuk M, Juszczak G, Sliwa AT, Tymosiak-Zielinska A, Lisowski P, Jaszczak K, Pluta R, Lipkowski A, Sadowski B, Swiergiel AH (2008) Differences in ethanol drinking between mice selected for high and low swim stress-induced analgesia. Alcohol 42: 487-492.
  • Sadowski B, Panocka I (1993) Cross-tolerance between morphine and swim analgesia in mice selectively bred for high and low stress-induced analgesia. Pharmacol Biochem Behav 45: 527-531.
  • Saito M, Ehringer MA, Toth R, Oros M, Szakall I, Sikela JM, Vadasz C (2003) Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoid­ing mice. Alcohol 29: 39-49.
  • Scherrer JF, Xian H, Shah KR, Volberg R, Slutske W, Eisen SA (2005) Effect of genes, environment, and lifetime co- occurring disorders on health-related quality of life in problem and pathological gamblers. Arch Gen Psychiatry 62: 677-683.
  • Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepres- sants in mice. Psychopharmacology (Berl) 85: 367-370.
  • Stevenson JR, Schroeder JP, Nixon K, Besheer J, Crews FT, Hodge CW (2008) Abstinence following alcohol drinking produces depression-like behavior and reduced hippocam- pal neurogenesis in mice. Neuropsychopharmacology 34: 1209-1222.
  • Torrens M, Fonseca F, Mateu G, Farre M (2005) Efficacy of antidepressants in substance use disorders with and with­out comorbid depression. A systematic review and meta­analysis. Drug Alcohol Depend 78: 1-22.
  • Weiss F, Ciccocioppo R, Parsons LH, Katner S, Liu X, Zorrilla EP, Valdez GR, Ben-Shahar O, Angeletti S, Richter RR (2001) Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Ann N Y Acad Sci 937: 1-26.
  • Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpre­dictable mild stress and its restoration by a tricyclic anti- depressant. Psychopharmacology (Berl) 93: 358-364.
  • Xuei X, Dick D, Flury-Wetherill L, Tian HJ, Agrawal A, Bierut L, Goate A, Bucholz K, Schuckit M, Nurnberger J Jr, Tischfield J, Kuperman S, Porjesz B, Begleiter H, Foroud T, Edenberg HJ (2006) Association of the kappa- opioid system with alcohol dependence. Mol Psychiatry 11: 1016-1024..
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