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Tytuł artykułu

GABA receptor subunits in human auditory cortex in normal and stroke cases

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Języki publikacji
GABA receptors are ubiquitous in the cerebral cortex and play a major role in shaping responses of cortical neurons. GABAA and GABAB receptor subunit expression was visualized by immunohistochemistry in human auditory areas from both hemispheres in 9 normal subjects (aged 43–85 years; time between death and fixation 6–24 hours) and in 4 stroke patients (aged 59–87 years; time between death and fixation 7–24 hours) and analyzed qualitatively for GABAA and semi-quantitatively for GABAB receptor subunits. In normal brains, the primary auditory area (TC) and the surrounding areas TB and TA displayed distinct GABAA receptor subunit labeling with differences among cortical layers and areas. In postacute and chronic stroke we found a layer-selective downregulation of the α2 subunit in the anatomically intact cerebral cortex of the intact and of the lesioned hemisphere, whereas the α1, α3 and β2/3 subunits maintained normal levels of expression. The GABAB receptors had a distinct laminar pattern in auditory areas and minor differences among areas. Unlike in other pathologies, there is no modulation of the GABAB receptor expression in subacute or chronic stroke.
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Opis fizyczny
  • Neuropsychology and Neurorehabilitation Service, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  • Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland
  • Neuropsychology and Neurorehabilitation Service, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  • Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland
  • Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland
  • Institute of Pathology, University of Basel, Basel, Switzerland
  • Institute of Pathology, University of Basel, Basel, Switzerland
  • Division of Neuropathology, Instuitute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  • Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, France
  • Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland
  • Neuropsychology and Neurorehabilitation Service, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
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