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2013 | 18 | 3 |
Tytuł artykułu

Calcium and phosphorus in medicine and treatment

Treść / Zawartość
Warianty tytułu
PL
Wapń i fosfor w medycynie i lecznictwie
Języki publikacji
EN
Abstrakty
EN
Calcium and phosphorus are essential for skeletal mineralization and perform a wide array of other biological functions. Calcium is a prime intracellular signalling molecule. It is also involved in muscle contractions (including the myocardium), digestion and blood coagulation. (T HEOBALD 2005) Phosphorus is an intrinsic constituent of many organic substances such as nucleotides, nucleosides, phosphoamino acids and proteins, phospholipids, phosphoglycans and others (H UANG , M OE 2011). In addition, it plays a critical role in cellular signalling through phosphorylation of proteins and other substances (S HAIKH et al. 2008). The present paper focuses on the role of these two elements in skeletal mineralization, and their use in treatment and medicine. First, it briefly discusses the calcium and phosphorus homeostasis, which occurs in three major organs: kidneys, intestines and bones, and involves an integrated hormonal system which maintains their normal serum levels. Moreover, disorders relevant to their abnormally high levels, hypercalcaemia and hyperphosphataemia, and excessively low levels, hypocalcaemia and hypophosphataemia, are described. Additionally, the physiology and pathology of bone as a prime store of both calcium and phosphorus are presented. Adequate intakes of these nutrients are essential for achieving the peak bone mass (PBM). A negative balance results from age-related bone loss, hence possible osteoporosis. This skeletal disorder is characterized by compromised bone strength, thus predisposing to an increased risk of fractures. One of the pharmacological interventions used in the treatment of osteoporosis is the administration of bisphosphonates. They inhibit the action of osteoclasts, prevent further bone losses and improve it strength (F ERRONE , G ERACI 2007). In the final part of the article, calcium phosphate based-ceramics, such as coralline hydroxyapatite, calcium hydroxyapatite (HAp), tri-calcium phosphate (TCP), bioglass, calcium phosphate cements (CPC) and their clinical applications are described.
PL
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
3
Opis fizyczny
p.529-539,ref.
Twórcy
autor
  • Chair and Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
autor
  • Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland
Bibliografia
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-46fabc5f-f72a-43fd-a59d-97008b8fdcf1
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