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2013 | 58 | 4 |
Tytuł artykułu

Associations between Demodex species infestation and various types of cancer

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Tumor-associated immune system cells secrete protease and cytokines that can inhibit the immune response. In particular, T-cell effector functions could be inhibited, potentially causing an increase in parasitic infestations. Demodex species are common inhabitants of normal hair follicles. Humans are the specific host for two species Demodex folliculorum and D. brevis. The aim of this study was to investigate the incidence and infestation of D. folliculorum and D. brevis in patients with cancer. In the present study, 101 patients with cancer were selected from among patients who were diagnosed and treated for cancer. The cancer patients were divided into four groups according to cancer type. Slides were examined for parasites using light microscopy at magnifications of ×40 and ×100. Infestation was defined as having at least five living parasites/cm2 of skin. The ages of the patients with cancer ranged between 38 and 82 years, with a mean of 65.5±10.1 years. It was determined that 77 of the 101 (76.2%) cancer patients were positive for Demodex species. Infestation was positive in 18 (47.4%) of the 38 cases in the breast cancer group, 7 (29.2%) of the 24 cases in the lung cancer group, 5 (18.5%) of the 27 cases in the gastrointestinal system cancer group, and 2 (16.7%) of the 12 cases in the urogenital system cancer group. Results showed that the rate of Demodex species infestation was higher in patients with breast cancer. Thus, cancer — and particularly breast cancer — is a risk factor for Demodex species infestation.
Wydawca
-
Czasopismo
Rocznik
Tom
58
Numer
4
Opis fizyczny
p.551-555,ref.
Twórcy
autor
  • Department of Oncology, School of Medicine, Sakarya University, Sakarya, Turkey
autor
  • Department of Microbiology, School of Medicine, Sakarya University, Sakarya, Turkey
autor
  • Department of Microbiology, School of Medicine, Sakarya University, Sakarya, Turkey
autor
  • Department of Microbiology, School of Medicine, Sakarya University, Sakarya, Turkey
autor
  • Department of Dermatology, School of Medicine, Sakarya University, Sakarya, Turkey
Bibliografia
  • Akdeniz S., Bahceci M., Tuzcu A.K., Harman M., Alp S., Bahceci S. 2002. Is Demodex folliculorum larger in diabetic patients?. Journal of the European Academy of Dermatology and Venereology, 16, 539–541.
  • Akilov O.E., Mumcuoglu K.Y. 2003. Association between human demodicosis and HLA class I. Clinical and Experimental Dermatology, 28, 70–73.
  • Akilov O.E., Mumcuoglu K.Y. 2004. Immune response in demodicosis. Journal of the European Academy of Dermatology and Venereology, 18, 440–444.
  • Baima B., Sticherling M. 2002. Demodicidosis revisited. Acta Dermato-Venereologica, 82, 3–6.
  • Ciftci I.H., Dundar U., Cetinkaya Z., Kulac M., Kiyildı N., Turel A., Evcik D., Kavuncu V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52, 70–73. DOI: 10.2478/s11686-007-0002-7.
  • Cogen A.L., Nizet V., Gallo R.L. 2008. Skin microbiota: a source of disease or defence? British Journal of Dermatology, 158, 442–455. DOI: 10.1111/j.1365-2133.2008.08437.x.
  • Dahl M.V., Ross A.J., Schlievert P.M. 2004. Temperature regulates bacterial protein production: possible role in rosacea. Journal of the American Academy of Dermatology, 50, 266–272.
  • Damian D., Rogers M. 2003. Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin. International Journal of Dermatology, 42, 724–726.
  • Dong H., Duncan L.D. 2006. Cytologic findings in Demodex folliculitis: a case report and review of the literature. Diagnostic Cytopathology, 34, 232–234.
  • Erbagci Z., Erbagci I., Erkilic S. 2003. High incidence of demodicidosis in eyelid basal cell carcinomas. Intrnational Journal of Dermatology, 42, 567–571.
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  • Jansen T., Kastner U., Kreuter A., Altmeyer P. 2001. Rosacea-like demodicidosis associated with Acquired İmmunodeficiency Syndrome. British Journal Dermatology, 144, 139–142.
  • Karaman U., Sener S., Samdanci E., Colak C., Sasmaz S. 2010. The incidence of Demodex species in skin biopsy specimens diagnosed as actinic keratosis and nonmelanoma skin cancer. Asian Biomedicine, 4, 343–348.
  • Kulac M., Ciftci I.H., Karaca S., Cetinkaya Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal Dermatology, 47, 72–77. DOI: 10.1111/j.1365-4632.2007.03336.x.
  • Lacey N., Raghallaigh S.N., Powel F.C. 2011. Demodex mites-commensal, parasites of mutualistic organisms?. Dermatology, 222, 128–130. DOI: 10.1159/000323009.
  • Morras P.G., Santos S.P., Imedio I.L., Echeverria M.L., Hermosa J.M. 2003. Rosacae-like Demodicidosis in an immunocompromised child. Pediatric Dermatology, 20, 28–30.
  • Patrizi A., Neri I., Chieregato C., Misciali M. 1997. Demodicidosis in immunocompetent young children: report of eight cases. Dermatology, 195, 239–242.
  • Seyhan M.E., Karincaoglu Y., Bayram N. Aycan O., Kuku I. 2004. Density of Demodex folliculorum in haematological malignancies. Journal of International Medical Research, 32, 411–415.
  • Sun J., Gui X., He J., Liu H.M., Yu H.Y., Xia C.Y., Xu Y. 2005. The relationship between infestation of Demodex folliculorum and epidermal neoplasm on face. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 23, 428–431.
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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