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2011 | 14 | 2 |
Tytuł artykułu

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibres supplying the porcine urinary bladder wall

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Abstrakty
EN
Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY- or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.
Wydawca
-
Rocznik
Tom
14
Numer
2
Opis fizyczny
p.181-189, fig.,ref
Twórcy
  • Department of Human Physiology, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-082 Olsztyn, Poland
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autor
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Bibliografia
  • Alm P, Zygmunt PK, Iselin C, Larsson B, Uvelius B, Werner S, Andersson KE (1995) Nitric oxide synthase-immunoreactive, adrenergic, cholinergic, and peptidergic nerves of the female rat urinary tract: a comparative study. J Auton Nerv Syst 56(1-2): 105-114.
  • Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O’Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K (2001)
  • Botulinum toxin as a biological weapon: medical and public health management. JAMA 285: 1059-1070.
  • Avelino A, Cruz F (2000) Peptide immunoreactivity and ultrastructure of rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin. Auton Neurosci 86: 37-46.
  • Awad SA, Bruce AW, Carro-Ciampi G, Downie JW, Lin M, Marks GS (1974) Distribution of alpha- and beta-adrenoceptors in human urinary bladder. Br J Pharmacol 50: 525-529.
  • Cervero F, Laird JM (2004) Understanding the signaling and transmission of visceral nociceptive events. J Neurobiol 61: 45-54.
  • Crowe R, Burnstock G (1989) A histochemical and immunohistochemical study of the autonomic innervation of the lower urinary tract of the female pig. Is the pig a good model for the human bladder and urethra? J Urol 141(2): 414-22.
  • Crowe R, Noble T, Robson T, Soediono P, Milroy EJ, Burnstock G R (1995). An increase of neuropeptide Y but not nitric oxide synthase-immunoreactive nerves in the bladder neck from male patients with bladder neck dyssynergia. J Urol 154: 1231-1236.
  • Crowe R, Vale J, Trott KR, Soediono P, Robson T, Burnstock G (1996). Radiation-induced changes in neuropeptides in the rat urinary bladder. J Urol 156: 2062-2066.
  • Csillik B, Janka Z, Boncz I, Kalman J, Mihaly A, Vecsei L, Knyihar E (2003) Molecular plasticity of primary nociceptive neurons: relations of the NGF-c-jun system to neurotomy and chronic pain. Ann Anat 185: 303-314.
  • Dickson A, Avelino A, Cruz F, Ribeiro-da-Silva A (2006) Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis. Neuroscience 139: 671-685.
  • Dickson EC, Shevky R (1923) Botulism. Studies on the manner in which the toxin of Clostridium botulinum acts upon the body: I. The effect upon the autonomic nervous system. J Exp Med 37: 711-731.
  • Dixon JS, Jen PY, Gosling JA (2000) The distribution of vesicular acetylcholine transporter in the human male genitourinary organs and its co-localization with neuropeptide Y and nitric oxide synthase. Neurourol Urodyn 19: 185-194.
  • Edvardsen P, Setekleiv J (1968) Distribution of adrenergic receptors in the urinary bladder of cats, rabbits and guinea-pigs. Acta Pharmacol Toxicol 26: 437-445.
  • el-Badawi A, Schenk EA (1966) Dual innervation of the mammalian urinary bladder. A histochemical study of the distribution of cholinergic and adrenergic nerves. Am J Anat 119: 405-427.
  • Gabella G, Davis C (1998) Distribution of afferent axons in the bladder of rats. J Neurocytol 27: 141-155.
  • Grosse J, Kramer G, Stohrer M (2005) Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence. Eur Urol 47: 653-659.
  • Haferkamp A, Schurch B, Reitz A, Krengel U, Grosse J, Kramer G, Schumacher S, Bastian PJ, Buttner R, Muller SC, Stohrer M (2004) Lack of ultrastructural detrusor changes following endoscopic injection of botulinum toxin type A in overactive neurogenic bladder. Eur Urol 46: 784-791.
  • Hamburger V (1992) History of the discovery of neuronal death in embryos. J Neurobiol 23:1116-1123.
  • Kaleczyc J (1994) Effect of estradiol and progesterone on noradrenaline content in nerves of the oviduct, uterus and vagina in ovariectomized pigs. Folia Histochem Cytobiol 32: 119-126.
  • Kaleczyc J, Timmermans J-P, Majewski M, Lakomy M, Scheuermann DW (1999) Immunohistochemical properties of nerve fibres supplying accessory male genital glands in the pig. A colocalization study. Histochem Cell Biol 111: 217-228.
  • Levin RM, Ruggieri MR, Wein AJ (1986) Functional effects of the purinergic innervation of the rabbit urinary bladder. J Pharmacol Exp Ther 236: 452-457.
  • Levin RM, Wein AJ (1979) Quantitative analysis of alpha and beta adrenergic receptor densities in the lower urinary tract of the dog and the rabbit. Invest Urol 17: 75-77.
  • Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A (1996) Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci 19: 514-520.
  • Łakomy M, Kotwica J, Całka J, Kaleczyc J (1986a) The effect of oestradiolum benzoicum and progesterone on the noradrenalin content in organs of the female reproductive system of sexually immature pigs. Gegenbaurs Morph Jahrb 132: 129-143.
  • Łakomy M, Kaleczyc J, Całka J (1986b) The effect of oestradiolum benzoicum and progesterone on AChE activity in the nerves of the female reproductive system of immature pigs. Gegenbaurs Morph Jahrb 132: 333-348.
  • Nergardh, A, Boreus LO (1972) Autonomic receptor function in the lower urinary tract of man and cat. Scand J Urol Nephrol 6: 32-36.
  • Persson K, Alm P, Johansson K, Larsson B, Andersson KE (1995) Co-existence of nitrergic, peptidergic and acetylocholine esterase-positive nerves in the pig lower urinary tract. J Auton Nerv Syst 52: 225-236.
  • Raezer DM, Wein AJ, Jacobowitz D, Corriere JN (1973) Autonomic innervation of canine urinary bladder. Cholinergic and adrenergic contributions and interaction of sympathetic and parasympathetic nervous systems in bladder function. Urology 2: 211-221.
  • Rapp DE, Turk KW, Bales GT, Cook SP (2006) Botulinum toxin type a inhibits calcitonin gene-related peptide release from isolated rat bladder. J Urol 175: 1138-1142.
  • Reitz A, Stohrer M, Kramer G, Del Popolo G, Chartier-Kastler E, Pannek J, Burgdorfer H, Gocking K, Madersbacher H, Schumacher S, Richter R, von Tobel J, Schurch B (2004) European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity. Eur Urol 45: 510-515.
  • Salimi M, Setekleiv J, Skobba TJ (1969) The sensitivity of adrenergic excitatory and inhibitory receptors in the smooth muscle of the rabbit urinary bladder. Acta Pharmacol Toxicol 27: 213-224.
  • Schurch B, Reitz A (2004) Botox in urology: a new treatment modality without limitations? EAU Update Series 2: 170-178.
  • Schurch B, Stöhrer M, Kramer G, Schmid DM, Gaul G, Hauri D (2000) Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results. J Urol 164: 692-697.
  • Sharkey KA, Kroese AB (2001) Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators. Anat Rec 262: 79-90.
  • Smith CP, Franks ME, McNeil BK, Ghosh R, de Groat WC, Chancellor MB, Somogyj GT (2003) Effect of botulinum toxin A on the autonomic nervous system of the rat lower urinary tract. J Urol 169: 1896-1900.
  • Thuroff JW, Bazeed MA, Schmidt RA, Luu DH, Tanagho EA (1982) Regional topography of spinal cord neurons innervating pelvic floor muscles and bladder neck in the dog: A study by combined horseradish peroxidase histochemistry and autoradiography. Urol Int 37: 110-120.
  • Wąsowicz K (2003) Effect of total or partial uterus extirpation on uterus-projecting neurons in porcine inferior mesenteric ganglion. Pol J Vet Sci 6: 131-145 (part A); 147-160 (part B); 161-172 (part C).
  • van Ermengem E (1897) Uber einen neuen anaeroben Bacillus and seine Beziehungen zum Botulismus. Zeitschrift fur Hygiene und Infektionskrankheiten 26: 1-56.
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