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2011 | 14 | 4 |
Tytuł artykułu

NT-pro-BNP and troponin I as predictors of morality in dogs with hearth failure

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The purpose of this study was to develop prognostic models for heart failure in dogs with dilated cardiomyopathy (DCM). The prospective study included 26 dogs with DCM and 58 healthy dogs. The ervation time median was 250 days (1-600 days). All the dogs were clinically examined, had echocardiography, electrocardiography, and morphological and biochemical blood sampling. Twenty four deaths were found in the group of dogs with DCM and 1 demise in the healthy dog's group. There was a significant increase in the level of NT-pro-BNP and cTnI (p<0.0005) in the group of dogs with DCM and a significant higher level of NT-pro-BNP and cTnI (p<0.0005) in the dead dogs from group with DCM that died or were euthanized up to the 60'th day of observation, compared to the animals that outlasted over 60 days of observation. The median level of NT-pro-BNP in the dogs which had short survival period (no more than 60 days) was 4865 pmol/L and the median level of cTnI in the same group of dogs was 0.63 ng/ml. The median level of NT-pro-BNP in the group of dogs with DCM, which lived longer than 60 days of observation was 978 pmol/l and the median level of cTnI in this group was 0.1 ng/ml. The level of NT-pro-BNP (r=0.79) and cTnI (r=0.4) correlated with the dogs' death. NT-pro-BNP and cTnI measurements could be useful to evaluate the survival the dogs with DCM. Increased level of NT-pro-BNP and cTnI is a bad prognosis. In the performed analysis of the Cox hazard regression it was found that cTnI level has a significant impact of the survival of the dogs (HR=8.54; Cl 1.1-46.6; p=0.02).
Słowa kluczowe
Wydawca
-
Rocznik
Tom
14
Numer
4
Opis fizyczny
p.551-556,ref.
Twórcy
  • Department of Internal Disease with Horses, Dogs and cats Clinic, Faculty of Veterinary Medicine,University of Environmental and Life Sciences, pl.Grunwaldzki 47, 50-366 Wroclaw, Poland
Bibliografia
  • Tidholm A, Haggstrom J, Borgarelli M, Tarducci A (2001) Canine idiopathic dilated cardiomyopathy. Part I: Aetiology, clinical characteristics, epidemiology and pathology. Vet J 162: 92-107.
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  • Meurs KM, Hendrix KP, Norgard MM (2008) Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy. Am J Vet Res 69: 1050-1053.
  • Werner P, Raducha MG, Prociuk U, Sleeper MM, Van Winkle TJ, Henthorn PS (2008) A novel locus for dilated cardiomyopathy maps to canine chromosome 8. Genomics 91: 517-521.
  • Spier AW, Meurs KM, Coovert DD, Lehmkuhl LB, O'grady MR, Freeman LM Burghes AH, Towbin JA (2001) Use of western immunoblot for evaluation of myocardial dystrophin, alpha-sarcoglycan and beta-dystroglycan in dogs with idiopathic dilated cardiomyopathy. J Am Vet Res 62: 67-71.
  • Noszczyk-Nowak A, Nowak M, Nicpoń J, Madej J (2009) Evaluation of desmin expression by immunohistochemistry in myocardial cells of dogs with dilated cardiomyopathy. Bull Vet Inst Pulawy 53: 509-513.
  • Meurs KM, Miller MW, Wright NA (2001) Clinical features of dilated cardiomyopathy in Great Danes and results of pedigree analysis: 17 cases (1990-2000). J Am Vet Med Assoc 218: 729-732.
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  • Dukes-McEwan J, Borgarelli M, Tidholm A, Vollmar AC, Haggstrom J (2003) Proposed guidelines for the diagnosis of canine idiopathic dilated cardiomyopathy. J Vet Cardiol 5: 7-19.
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  • Tidholm A (2006) Survival in dogs with dilated cardiomyopathy and congestive heart failure treated with digoxin, furosemide and propranolol: A retrospective study of 62 dogs. J Vet Cardiol 8: 41-47.
  • O'Brien PJ (1997) Deficiencies of myocardial troponin-T and creatine kinase MB isoenzyme in dogs with idiopathic dilated cardiomyopathy. Am J Vet Res 58: 11-16.
  • Oyama MA, Sisson DD (2004) Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med 18: 831-839.
  • Oyama MA, Sisson DD, Solter PF (2007) Prospective screening for occult cardiomyopathy in dogs by measurement of plasma atrial natriuretic peptide, B-type natriureticpeptide, and cardiac troponin-I concentrations. Am J Vet Res 68: 42-47.
  • Oyama MA, Singletary GE (2010) The use of NT-proBNP assay in management of canine patients with heart disease. Vet Clin North Am Small Anim Pract 40: 545-558.
  • O'Sullivan ML, O'Grady MR, Minors SL (2007) Plasma big endothelin-1, atrial natriuretic peptide, aldosterone, and norepinephrine concentrations in normal Doberman Pinschers and Doberman Pinschers with dilated cardiomyopathy. J Vet Intern Med 21: 92-99.
  • Freeman LM, Rush JE, Farabaugh AE, Must A (2005) Development and evaluation of a questionnaire for assessing health-related quality of life in dogs with cardiac disease. J Am Vet Med Assoc 226: 1864-1868.
  • Dukes-McEwan J, Jackson IJ (2002) The promises and problems of linkage analysis by using the current canine genome map. Mamm Genome 13: 667-672.
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  • Oyama MA, Fox PR, Rush JE, Rozanski EA, Lesser M (2008) Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J Am Vet Med Assoc 232: 1496-1503.
Typ dokumentu
Bibliografia
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