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2016 | 19 | 1 |
Tytuł artykułu

Rush sublingual immunotherapy in canine atopic dermatitis: a prospective pilot study

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Twenty dogs with canine atopic dermatitis (CAD) were treated with rush sublingual immunotherapy (SLIT), with a 48 hour build-up phase and 6 months maintenance phase (treated by antigen once every 3-4 weeks). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (baseline) and after 6 months. An open, non-controlled, non-randomized pilot trial was conducted to assess the effectiveness and safety of rush SLIT for environmental allergen extracts (Dematophagoides pteronyssinus and D.farinae mix and other). Three dogs dropped out and 17 dogs finished the trial. CADESI-4 at baseline was 60.6±27.1 (range 17-107, n=17). After 6 months of SLIT treatment, CADESI-4 was 37.4±36.0 (range 5-152, n=17) (p <0.01), which was a 38.3% reduction. A significant improvement, defined as a CADESI-4 reduction of > 30%, was observed in 13 out of 17 dogs (76%). A moderate improvement, defined as a CADESI-4 reduction of<= 30%, was observed in 2 dogs (12%). In the other 2 dogs (12%), CADESI-4 worsened or showed no change. However, no severe adverse effects were observed during the trial. Therefore, rush SLIT against environmental allergen extract for CAD showed effectiveness and safety as evidenced by the reduction of CADESI-4 after 6 months SLIT without severe adverse effects.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
19
Numer
1
Opis fizyczny
p.3-6,ref.
Twórcy
autor
  • Fujimura Animal Allergy Hospital 10-26 5-choume Aomatanihigashi, Mino, Osaka, 562-0022, Japan
autor
  • Fujimura Animal Allergy Hospital 10-26 5-choume Aomatanihigashi, Mino, Osaka, 562-0022, Japan
Bibliografia
  • Canonica GW, Bousquet J, Casale T, Lockey RF, Baena-Cagnani CE, Pawankar R, Potter PC, Bousquet PJ, Cox LS, Durham SR, Nelson HS, Passalacqua G, Ryan DP, Brozek JL, Compalati E, Dahl R, Delgado L, van Wijk RG, Gower RG, Ledford DK, Filho NR, Valovirta EJ, Yusuf OM, Zuberbier T, Akhanda W, Almarales RC, Ansotegui I, Bonifazi F, Ceuppens J, Chivato T, Dimova D, Dumitrascu D, Fontana L, Katelaris CH, Kaulsay R, Kuna P, Larenas-Linnemann D, Manoussakis M, Nekam K, Nunes C, O’Hehir R, Olaguibel JM, Onder NB, Park JW, Priftanji A, Puy R, Sarmiento L, Scadding G, Schmid-Grendelmeier P, Seberova E, Sepiashvili R, Sole´ D, Togias A, Tomino C, Toskala E, Van Beever H, Vieths S (2009) Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009. Allergy 64: 1-59.
  • Cadario G, Galluccio AG, Pezza M, Appino A, Milani M, Pecora S, Mastrandrea F (2007) Sublingual immunotherapy efficacy in patients with atopic dermatitis and house dust mite sensitivity: a prospective study. Curr Med Res Opin 23: 2503-2506.
  • DeBoer DJ, Verbrugge M, Morris M (2016) Clinical and immunological responses of dust mite sensitive, atopic dogs to treatment with sublingual immunotherapy (SLIT). Vet Dermatol 8. doi: 10.1111/vde.12284.
  • Favrot C, Steffan J, Seewald W, Picco F (2010) A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 21: 23-31.
  • Mueller SR, Bettenay SV (2001) Evaluation of safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Am J Vet Res 62: 307-310.
  • Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB: International Committee on Allergic Diseases of Animals (ICADA). (2014) Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol 25: 77-85.
  • Olivry T, DeBoer DJ, Favrot C, Jackson HA, Mueller RS, Nuttall T, Prelaud P (2015) International Committee on Allergic Diseases of Animals. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res 11: 210.
  • Radulovic S, Wilson D, Calderon M, Durham S (2011) Systemic reviews of sublingual immunotherapy (SLIT). Allergy 66: 740-752.
  • Trimmer AM, Griffin CE, Boord MJ, Rosenkrantz WS (2005) Rush allergen specific immunotherapy protocol in feline atopic dermatitis: a pilot study of four cats. Vet Dermatol 16: 324-329
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-06f027db-1882-437e-a130-dc83debc9316
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