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2017 | 10 |
Tytuł artykułu

Synthesis, characterization and antifungal activity of some fluorine containing 1,3,5-trisubstituted pyrazoline derivatives

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A series of (E)-1-(4-fluorophenyl)-3-substitutedphenylprop-2-en-1-one (3-7) were ultrasonically prepared by the reaction of 4-fluoroacetophenone with different aromatic aldehydes in the presence of alkali . Reaction of the prepared chalcones (3-7) with 3,4,5-trimethoxybenzohydrazide (8) afforded the corresponding substituted pyrazoline (9-13). Ultrasonic irradiation method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times and good yields. All the prepared compounds have been characterized by FT-IR and 1H-NMR spectra. These compounds were screened for their antifungal activity using disc diffusion method. Compound 10 and 11 was found to exhibit the most potent in-vitro anti-fungal activity with against all the fungal strains.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
10
Opis fizyczny
p.86-94,fig.,ref.
Twórcy
  • Department of Chemistry, Government Arts College, C-mutlur, Chidambaram, Tamil Nadu, India
autor
  • Department of Chemistry, Government Arts College, C-mutlur, Chidambaram, Tamil Nadu, India
Bibliografia
  • [1] K. C. Joshi, A. Dandia, S. Khanna, Indian Journal of Chemistry – Section B: Organic Chemistry Including Medicinal Chemistry 29 (1990) 1125-1128.
  • [2] H. Deng, D. O’Hagan, C. Schaffrath, Natural Products Reports 21 (2004) 773-784
  • [3] Singh O. V. & Muthukrishnan M., Ind J of Chem, Vol-44B (2005) 2575-2581.
  • [4] Singh J. P., Dulwat M., Jaitawat N., Chundawat S. S., Devpura A., & Dulwat S. S., Ind J Chem. 51B (2012) 1623-1627.
  • [5] Shelke, S. N., Mhaske G. R., Bonifacio V. D. B., Gawande M. B., Bioorg Med Chem Lett. 22 (2012) 5727-5730
  • [6] Ghorab M. M., El-Gazzar M. G., Alsaid M. S., Int. J. Mol. Sci. 15 (2014) 7539-7553.
  • [7] Penning, T. D., Talley, J. J., Bertenshawm, S. R., Carter, J. S., Collins, P.W., Docter, S., Graneto, M. J., Lee, L. F., Malecha, J. W., Miyashiro, J. M., et al. J. Med. Chem. 40 (1997) 1347-1365
  • [8] Kumar S., Bawa, S., Drabu S., Kumar R., Gupta H., Recent Pat. Antiinfect Drug Discov. 2009, (2009) 154.
  • [9] Taj T., Kamble R. R., Gireesh T. M., Hunnur R. K., Margankop S. B., Eur. J. Med. Chem. 2011, 46, 4366.
  • [10] Barry, A. L., in: The antimicrobial susceptibility test: Principle and Practice, Lea and Febiger, Philadelphia, 180 (1976).
  • [11] S. Balaji, R. Senbagam, M. Rajarajan, R. Vijayakumar, V. Manikandan, G. Vanangamudi, G. Thirunarayanan, Synthesis and antimicrobial activity of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds. World Scientific News 52 (2016) 14-30
  • [12] G. Thirunarayanan, V. Manikandan, R. Aarulkumaran, R. Rarajan, V. Usha, Spectral studies and antimicrobial activities of some (E)-N-(substituted benzylidene)-2,6-diisopropylanilines. World Scientific News 66 (2017) 20-42
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-011aef73-311f-4098-866f-45f1d18e3847
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