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2011 | 83 | 6 | 334-338
Tytuł artykułu

Association of the-801G/A Polymorphism ofCXCL12Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Inflammatory bowel diseases (IBDs), mainly ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic and idiopathic inflammatory conditions of gastrointestinal tract that are immunologically mediated. Stromal cell-derived factor 1 (CXCL12) has been demonstrated to be involved in the pathophysiology of IBD.The aim of the study was to investigate whether the CXCL12 -G/A polymorphism (rs1801157) is associated to IBD in a sample of Polish population.Material and methods. A total of 188 patients with IBD including 103 patients with CU and 72 patients with CD and 184 controls were enrolled in the study. Both groups came from the Polish population. The G/A polymorphism of CXCL12 was determined by PCR-RFLP analysis.Results. There was no association between G/A polymorphism at position -801 promoter region of CXCL12 gene and increased risk of IBD. The study population was not found a difference in genotype distribution between the control group and with both CD and CU patients.Conclusions. These results suggest that G/A polymorphism at position -801 promoter region of CXCL12 gene relates neither to the risk of the development of inflammatory bowel disease nor to the clinical subtypes of IBD in the Polish population. Whether this polymorphism truly contributes to disease susceptibility needs to be further addressed, and should stimulate additional studies in other populations.
Wydawca

Rocznik
Tom
83
Numer
6
Strony
334-338
Opis fizyczny
Daty
wydano
2011-06-01
online
2011-07-25
Twórcy
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of Gastroenterology and Internal Diseases, Medical University in Łódź
  • Department of Gastroenterology and Internal Diseases, Medical University in Łódź
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
Bibliografia
  • Bartnik W: Wytyczne postępowania w nieswoistych chorobach zapalnych jelit. Przegl Gastroenterol 2007; 2 (5)
  • Kamińska B, Lewandowski P: Rola wybranych czynników środowiskowych w etiopatogenezie nieswoistych zapaleń jelit. Forum Medycyny Rodzinnej 2009; 3(1): 42-48.
  • Matsuura T, West GA, Youngman KR et al.: Immune activation genes in inflammatory bowel disease. Gastroenterology 1993; 104(2): 448-58.
  • Pena AS et al.: Genetics and epidemiology may contribute to understanding the pathogenesis of IBD- a new approach is now indicated. Can J Gastroenterol 1993; 7: 71-75.
  • Mikami S, Nakase H, Yamamoto S et al.: Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther 2008; 327(2): 383-92.[WoS]
  • Dotan I, Werner L, Vigodman S et al.: CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system. InflammBowelDis 2010; 16(4): 583-92.
  • Eash KJ, Means JM, White DW et al.: CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 2009; 113, 4711-19.[WoS]
  • Winkler C, Modi W, Smith MW et al.: Geneticrestriction of AIDS pathogenesis by an chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science 1998; 279: 389-93.
  • Watanabe MA, de Oliveia Cavassin GG, Orellana MD et al.: SDF-1 gene polymorphisms and syncytia induction in Brazilian HIV-1 infected individuals. MicrobPathog 2003; 35: 31-34.
  • Razmkhah M, Doroudchi M, Ghayumi SM et al.: Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer. Lung Cancer 2005 Sep; 49(3): 311-15.[Crossref][PubMed]
  • Razmkhah M, Talei AR, Doroudchi M et al.: Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. Cancer Lett 2005 Jul 28; 225(2): 261-66.
  • Hirata H, Hinoda Y, Kikuno N et al.: CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. Clin Cancer Res 2007 Sep 1; 13(17): 5056-62.
  • Hartl D, Krauss-Etschmann S, Koller B et al.: Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol 2008 1; 181(11): 8053-67.
  • Krumbholz M, Theil D, Cepok S et al.: Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006; 129: 200-11.
  • Chen HT, Tsou HK, Hsu CJ et al.: Stromal cell-derived factor-1/CXCR4 promotes IL-6 production in human synovial fibroblasts. J Cell Biochem 2011; 112(4): 1219-27.[WoS]
  • Tsai HT, Tee YT, Hsieh YH et al.: Elevated plasma stromal cell-derived factor 1 protein and its gene polymorphism in patients with pelvic inflammatory disease. Reprod Sci 2009; 16(6): 610-17.[WoS][Crossref][PubMed]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-011-0051-3
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