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2010 | 82 | 11 | 591-595
Tytuł artykułu

Assesment of Diagnostic and Prognostic Value of Transduodenal Fine Nedle Biopsy in Patients with Tumors of the Pancreatic Head in the Material of Deparment of General, Gastroenterological and Endocrinological Surgery, Medical University in Poznań

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Pancreatic cancer is the thirteen leading most common malignancy, accounting for up to 2% of all malignancies. In majority of cases pancreatic cancer is diagnosed when local progression of the malignancy makes radical surgical treatment impossible. The extent of surgical treatment of tumors of the pancreatic head is planned on the basis of preoperative imaging studies and endoscopic studies and the final decision depends on intraoperative assessment of the lesion progression and results of cytological or histopathological examination of intraoperatively collected specimens. Fine needle aspiration biopsy (FNAB) is performed before possible resection of the tumor of the pancreatic head.The aim of the study was to compare results of FNAB with final histopathological assessment of collected specimen and survival of patients with negative cytological examination and patients in whom transduodenal fine needle aspiration biopsy confirmed the presence of cancer cells.Material and methods. This retrospective study involved 63 patients hospitalized due to tumor of the pancreatic head in Department of General, Gastroenterological and Endocrinological Surgery between 2000 and 2007. All patients underwent fine needle aspiration biopsy during the laparotomy. In some patients, an intraoperative decision was taken to proceed to core biopsy from suspected malignancy sites despite negative result of cytological examination. This analysis included only patients with evaluable material collected for cytological examination. Long-term results of treatment were obtained basing on clinical examination of patients who attended a follow-up visit and telephone survey conducted among patients and their families in the event of patients who did not attend a followup visit.Results. The longest overall survival of patients with positive cytological examination who underwent a palliative procedure was 10 months, while in patients who underwent radical treatment amounted to 2 years. Sensitivity of fine needle aspiration biopsy (FNAB) in our study was 85.7%Conclusions. FNAB is an indispensible part of diagnostic workup in the pancreatic cancer and cannot be omitted even in inoperable cancers confirmed by imaging studies. FNAB not only guides surgical treatment but also dictates adequate adjuvant and neoadjuvant systemic therapy - radio- and chemotherapy.
Wydawca
Rocznik
Tom
82
Numer
11
Strony
591-595
Opis fizyczny
Daty
wydano
2010-11-01
online
2011-01-07
Twórcy
  • Chair and Department of General, Gastroenterological and Endocrinological Surgery, Medical University in Poznań
  • Department of Surgery, F. Raszei Hospital in Poznań
autor
  • Chair and Department of General, Gastroenterological and Endocrinological Surgery, Medical University in Poznań
  • Department of Pathomorphology, Medical University in Poznań
  • Department of Pathomorphology, Medical University in Poznań
  • Chair and Department of General, Gastroenterological and Endocrinological Surgery, Medical University in Poznań
Bibliografia
  • John L: Cameron, MD Atlas of Clinical Oncology - Pancreatic Cancer, 2001.
  • Yamao K, Sawaki A, Mizuno N et al.: Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNBA): past, present and future. J Gastroenterol 2005; 40: 1013-23.
  • Vazquez-Sequeiros E: Endoscopic ultrasound and fine needle aspiration in inflammatory and cystic pancreatic pathology. Minerva Med 2007; 98(4):357-60.
  • Pausawasdi N, Scheiman J: Endoscopic evaluation and palliation of pancreatic adenocarcinoma: current and future options. Curr Opin Gastroenterol 2007; 23(5): 515-21.[PubMed][Crossref]
  • Boujaoude J: Role of endoscopic ultrasound in diagnosis and therapy of pancreatic adenocarcinoma. World J Gastroenterol 2007; 13(27): 3662-66.[PubMed]
  • Golbin SB, Brander MW, Zerwos EE: Rosemurgy AS2nd, Assesment of pancreatic neoplasms: rewiew of biopsy techniques. J Gastroenterol Surg 2007; 11(6): 783-90.
  • Chang F, Chandara A, Culora G et al.: Cytologic diagnosis of pancreatic endocrine tumors by endoscopic ultrasound-guided fine-needle aspiration: a review. Diagn Cytopathol 2006 34(9): 649-58.[Crossref]
  • Liman G: My approach to pancreatic fine needle aspiration. J Clin Patrol 2007; 60(1): 43-49.[Crossref]
  • Michl P, Pauls S, Gress TM: Evidence based diagnosis and staging of pancreatic cancer. Best Prac Res Clin Gastroenterol 2006; 20(2): 227-51.[Crossref]
  • Schlieman MG, Ho H, Bold RJ: Utility of tumor markers in determining resectability of pancreatic cancer. Arch Surg 2003; 138: 951-56.
  • Beger HG, Rau B, Gansauge F et al.: Treatment of pancreatic cancer: challenge of the facts. World J Surg 2003; 27: 1075-84.
  • Zheng M, Liu LX, Zhu AL et al.: K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses. World J Gastroenterol 2003; 9: 188-91.
  • Urbach DR, Bell CM, Swanstrom LL et al.: Cohort study of surgical bypass to the gallbladder or bile duct for the palliation of jaundice due to pancreatic cancer. Ann Surg 2003; 237: 86-93.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-010-0089-7
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