PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 82 | 8 | 454-458
Tytuł artykułu

Oxidative protein damage in patients with colorectal cancer

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Colorectal cancer is a major public health concern particularly in developed countries. Despite decades of advances in the treatment and prevention of colorectal cancer, it remains the second most common cause of cancer death. There now exists convincing evidence that reactive oxygen species play an important role in the etiology and progression of a number of human diseases including colorectal cancer. Reactive oxygen species may damage all types of biological molecules. However, proteins are possibly the most immediate vehicle for inflicting oxidative damage on cells since they are often catalysts rather than stoichiometric mediators, hence, the effect of damage to one molecule is greater than stoi-chiometric.The aim of the study was to investigate oxidative protein damage in patients with colorectal cancer and its correlation with the clinical stage of the disease.Material and methods. The study group comprised 102 patients operated on for colorectal cancer in different clinical stages of the disease. Plasma carbonyl levels were determined using Levin's method.Results. Patients in all tumor groups showed significantly higher levels of plasma carbonyls when compared to healthy people. We observed an increase in mean plasma carbonyl levels correlating with an increase in the degree of disease advancement.Conclusions. This study demonstrates that reactive oxygen species may have a role in pathogenesis of colorectal cancer. The outcomes of this research seem to confirm that antioxidants may play a role in chemoprevention of colorectal cancer.
Wydawca

Rocznik
Tom
82
Numer
8
Strony
454-458
Opis fizyczny
Daty
wydano
2010-08-01
online
2010-09-22
Twórcy
  • Department of General and Colorectal Surgery, Medical University, Łódź
  • Department of General and Colorectal Surgery, Medical University, Łódź
  • Department of General and Colorectal Surgery, Medical University, Łódź
  • Department of Endoscopy and One Day Gastroenterology, Biegański Memorial Regional Specialistic Hospital, Łódź
  • Department of Chemistry and Clinical Biochemistry, Medical University, Łódź
autor
  • Department of General and Colorectal Surgery, Medical University, Łódź
Bibliografia
  • Korniluk J, Wcisło G, Nurzynski P i wsp.: Epidemiologia raka jelita grubego. Współcz Onkol 2006; 10: 136.
  • Jemal, R. Siegel, E: Ward et al.: Cancer Statistic. CA Cancer J Clin 2008; 58: 71-96.
  • Zatoński W, Tyczyński J: Nowotwory złośliwe w Polsce w 1996 roku. Biuletyn Centrum Onkologii w Warszawie. Warszawa 1999.
  • Paz-Elizur T, Sevilya Z, Leitner-Dagan Y et al.: DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention. Cancer Lett 2008; 226: 60-72.[WoS]
  • Ponczek MB, Wachowicz B: Oddziaływanie reaktywnych form tlenu i azotu z białkami. Postępy Biochem 2005; 51: 140-45.
  • Dalle-Donne I, Rossi R, Giustrarini D et al.: Protein carbonyl groups as biomarker of oxidative stress. Clin Chim Acta 2003; 329: 23-38.
  • Levine RL, Garland D, Oliver CN et al.: Determination of Carbonyl Content in Oxidatively Modified Proteins. Methods Enzymol 1990; 186: 464-78.
  • Bertrandt J: Antyoksydanty w profilaktyce i leczeniu chorób cywilizacyjnych. Wojskowa Farmacja i Medycyna 2008; 1: 7-15.
  • Łuczaj W, Skrzydlewska E: Współczesne spojrzenie na peroksydację lipidów. Postępy Biochem 2006; 52: 173-179.
  • Stadtman ER, Bedett BS: Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 1998; 30: 225-43.
  • Beal MF: Oxidatively modified proteins in aging and disease. Free Radic Biol Med 2002; 32: 797-803.
  • Shacter E: Quantification and significance of protein oxidation in biological samples. Drug Metab Rev 2000; 32: 307-26.
  • Popadiuk S, Landowski P, Korzon M i wsp.: Grupy karbonylowe w białkach osocza u dzieci z przewlekłym nieswoistym zapaleniem jelit. Pediatr Współcz 2001; 2: 195-98.
  • Levine RL: Carbonyl modified proteins in cellular regulation, aging and disease. Free Radic Biol Med 2002; 32: 790-96.
  • Popadiuk S, Korzon M, Renke J i wsp.: Ocena aktywności reakcji wolnorodnikowych na podstawie analizy peroksydacji białek w powiązaniu z całko-witą obroną przeciwutleniaczową krwi u dzieci z chorobą nowotworową. Wiad Lek 1998; 51 Suppl. 4: 107-12.
  • Pignatelli B, Li CQ, Boffetta P at al.: Nitrated and oxidized plasma proteins in smokers and lung cancer patients. Cancer Res 2001; 61: 778-84.
  • Yilmaz IA, Akçay T, Cakatay U et al.: Relation between bladder cancer and protein oxidation. Int Urol Nephrol 2003; 35: 345-50.
  • Drew JE, Rucklidge GJ, Duncan G et al.: A proteomics approach to identify changes in protein profiles in pre-cancerous colon. Biochem Biophys Res Commun 2005; 1: 81-87.
  • Chang D, Wang F, Zhao YS et al.: Evaluation of oxidative stress in colorectal cancer patients. Biomed Environ Sci 2008; 4: 286-89.[WoS]
  • Gaweł S, Wardas M, Niedworok E i wsp.: Dialdehyd malonowy jako wskaźnik procesów peroksydacji lipidów w organizmie. Wiad Lek 2004; 47: 453-55.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-010-0065-2
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.