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2010 | 82 | 2 | 95-100
Tytuł artykułu

Adrenal Metastases

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was an retrospective assessment of adrenal metastases based on the analysis of patients operated on in three surgical institutions between 2001 and 2005.Material and methods. Between 2001 and 2005 169 patients (106 females and 63 males) were treated due to adrenal tumors. The age of patients ranged between 25 and 82 years (mean 55.4± 11.8 years). All patients were routinely diagnosed by means of ultrasound, computed tomography or magnetic resonance imaging and hormonal tests such as cortisol, chromogranine A, aldosterone and natrium, potassium concentrations. Patients were surgically managed after preparation dependent on general status, tumor type and concomitant diseases. Operations were carried out using classic techniques via lumbar approach in 146 cases (86.4%) or videoscopic techniques via retroperitoneal or transperitoneal approaches (13.6%).Results. In 143 cases (84.6%) benign tumors and in 26 (15.4%)-malignant lesions were diagnosed. 16 (9.5% of all cases and 61.5% of malignant tumors) were secondary- metastases form various cancers treated previously. Adrenal metastases occurred most often in the 7th decade (43.7%), and primary site was clear cell carcinoma of the kidney (9 cases - 56.25%) and non-small cell lung cancer (4 - 25%), melanoma (2 cases - 12.5%) and rectal cancer (1 - 6.25%). During the follow-up of 1-5 years (mean 3.1 years) 12 patients died of metastatic tumors - 6 with multiple metastases and 6 with solitary adrenal metastasis. 4 patients are still alive with metastatic deposits in the adrenal glands (at the moment of adrenalectomy) - 3 with metastatic renal cancer (currently 2 without other metastases) and 1 with disseminated lung cancer.Conclusions. 1. Adrenal metastases are the most frequent malignant tumors of these glands. 2. Metastatic tumors occur most often during the 6th and 7th decades. 3. Results of treatment are not satisfactory and dependent on the extent of spread.
Słowa kluczowe
Wydawca
Rocznik
Tom
82
Numer
2
Strony
95-100
Opis fizyczny
Daty
wydano
2010-02-01
online
2010-03-18
Twórcy
  • Department of General and Oncological Surgery, Medical University in Łódź
  • Department of Surgery, Ministry of Internal Affairs' Hospital in Łódź
  • Department of Thoracic and General Surgery and Surgical Oncology, Medical University in Łódź
  • Department of Endocrine and General Surgery, Medical University in Łódź
  • Department of General and Oncological Surgery, Medical University in Łódź
  • Department of Endocrine and General Surgery, Medical University in Łódź
Bibliografia
  • Tołłoczko T: Nowotwory nadnercza. W: Szawłowski AW, Szmidt J (red.) Zasady diagnostyki i chirurgicznego leczenia nowotworów w Polsce. Fundacja - Polski Przegląd Chirurgiczny. Warszawa 2003 s.143-151.
  • Ed. DeLellis RA, Lloyd RV, Heitz Ph.U et al.: World Health Organization Classification of Tumours. Patholoy & Genetics. Tumours of Endocrinre Organs. IARC Press Lyon 2004.
  • Wajda Z, Kwiecińska B, Stefaniak T: Chirurgia nadnerczy. W: Gruca Z (red.) Pamiętnik 61. Zjazdu Towarzystwa Chirurgów Polskich. Gdańsk 17- 20.09.2003 r. Chirurgia Endokrynologiczna. Gdańsk 2003. 36-41.
  • Steward PM: The adrenal cortex. W: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS. (red.) Textbook of Endocrinology 10th Ed. Saunders. Philadelphia. 2002; s.491-551.
  • Kasperlik-Załuska A, Otto M, Cichocki A et al.: 1161 Patients with adrenal incidentalomas (AI): indications for surgery. Proceeddings of 2nd Biennial Congress of the European Society of Endocrine Surgeons ESES Kraków. May 18-20. 2006; 51.
  • Kloss RT, Gross MD, Francis IR et al.: Incidentally discovered adrenal masses. Endocr Rev 1995; 16: 460-84.
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  • McNicholas MM, Lee MJ, Mayo-Smith WW et al.: An imaging algorithm for the differential diagnosis of adrenal adenomas and metastases. AJR Am J Roentgenol 1995; 165(6): 1453-59.[PubMed][Crossref]
  • Liao CH, Chueh SC, Lai MK et al.: Laparoscopic adrenalectomy for potential malignant adrenal tumors greater than 5 centimeters. J Clin Endocrinol Metab 2006; 91(8): 3080-83.
  • Lam KY, Lo CY: Metastatic tumours of the adrenal glands: a 30-yer experience in a teaching hospital. Clin Endocrinol (Oxf) 2002; 56: 95-101.[Crossref]
  • Abrams HL, Spiro R, Goldstein N: Metastases in carcinoma. Aalysis of 1000 autopsied cases. Cancer 1950; 3: 74-85.
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  • Xu J, Wang R, Xie ZH et al.: Prostate cancer metastasis: Role of the host microenvironment in promoting epithelial to mesenchymal transition and increased done and adrenal metastasis. Prostate 2006; 66(15): 1664-73.[Crossref][PubMed]
  • Kocijancic I, Vidmar K. Zwitter M et al.: The significance of adrenal metastases from lung carcinoma. Eur J Surg Oncol 2003; 29(1): 87-88.[Crossref]
  • Guzzini F, Cozzi C, Cortese F et al.: Adrenal failure due to bilateral metastases as the manifestation of relapsing lung carcinoma. Report of two cases. Tumori 1989; 75: 634-36.[PubMed]
  • Seidenwurm DJ. Elmer EB. Kaplan LM et al.: Metastases to the adrenal glands and the development of Addison‵s disease. Cancer 1984; 54(3): 552-57.[Crossref]
  • Lucchi M, Dini P, Ambrogi MC et al.: Metachronous adrenal masses in resected non- small cell lung cancer patients; therapeutic implications of laparoscopic adrenalectomy. Eur J Cardiothorac Surg 2005; 27(5): 753-56.[PubMed][Crossref]
  • Shalev M, Cipolla B, Guille F et al.: Is ipsilateral adrenalectomy a necessary component of radical nephrectomy? J Urol 1995; 153(5): 1415-17.[PubMed]
  • Antonelli A, Cozzoli A, Simeone C et al.: Surgical treament of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients. BJU Int 2006; 97(3): 505-08.[Crossref]
  • Henry JF, Sebag F, Iacobone M et al.: Results of laparoscopic adrenalectomy for large and potentially malignant tumors. World J Surg 2002; 26(8): 1043-47.[Crossref][PubMed]
  • Walz MK, Peigen K, Diesing D et al.: Partial versus total adrenalectomy by the posterior retroperitoneoscopic approach: early and long-term results of 325 consecutive procedures in primary adrenal neoplasias. World J Surg 2004; 28(12): 1323-29.[Crossref]
  • Budzyński A, Lubikowski J, Rembiasz K et al.: Laparoscopic adrenalectomy; retroperitoneal v. transperitoneal. Procedings of European Society of Endocrine Surgeons ESES 2nd Biennial Congress, May 18-20 2006 Kraków.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-010-0015-z
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