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2007 | 79 | 12 | 753-761
Tytuł artykułu

DNA Ploidy in the Treatment of Stomach Adenocarcinoma: A Follow-Up Study

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was to determine unfavourable prognostic factors for patients with stomach adenocarcinoma after their surgical treatment through evaluation of prognostic indicators for cellular ploidy and proliferative activity.Material and methods. A group of 51 patients following surgical treatment due to stomach adenocarcinoma and discharged from our hospital between 1995-2000 were studied here. The material examined was encased in paraffin blocks. After histopathological verification, the tumour segments within these blocks were used for cytofluorometric analysis of DNA-ploidy according to Hedley's method.Results. In 41 (80.4%) stomach cancer patients (out of the total group of 51 patients), diploid tumours were found. No significant relationship between DNA ploidy and sex, age, symptoms, inherited susceptibility to a disease, tumour magnitude, grade of histological malignancy, or grade of clinical progression was observed. Generally, after the stomach cancer operation, the probability of five-year survival was 22.1% for patients with diploid tumours (DI=1.0), and 20% for the patients with aneuploid tumours (DI ± 1.0). The probability of 10-year survival was 19.2% for diploid tumours, and 10% for aneuploid tumours. These differences were not statistically significant (p=0.255).Conclusions. 1. Classical clinicopathologic factors are still the best prognostic criteria for the evaluation of long-term results of surgical treatment for stomach cancer patients. 2. Determination of DNA-ploidy and proliferative activity of stomach cancer did not decrease the gap between long-term results prognosis for surgical treatment and actual results.
Wydawca

Rocznik
Tom
79
Numer
12
Strony
753-761
Opis fizyczny
Daty
wydano
2007-12-01
online
2008-02-11
Twórcy
  • Department of General Surgery, Silesian Medical University, Katowice
  • Department of Surgery, Public Hospital, Zabrze
  • Department of Surgery, Public Hospital, Zabrze
  • Department of Neoplasm Pathology, Cracow Branch of Oncology Centre
  • Department of General Surgery, Silesian Medical University, Katowice
  • Department of General Surgery, Silesian Medical University, Katowice
Bibliografia
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  • Lee KH, Lee JS, Lee JH et al.: Prognostic value of DNA flow cytometry in stomach cancer: a 5-year prospective study; Br J Cancer 1999; 79: 1727-35.[Crossref]
  • Hedley DW, Friedlander ML, Taylor IW et al.: Metod for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333-35.[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-007-0117-4
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