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2007 | 79 | 4 | 269-272
Tytuł artykułu

Morphological Changes in the Stomach Mucosa of Rats Caused by Endogenous Bile Acids

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
"Bile reflux" is a common term to denote a process of placing duodenal contents in the stomach and/or lower oesophagus. It is most often associated with functional or organic failure of the pylorus and is a not uncommon postoperative condition after pyloric section, resection or by-passing.Gastrotoxicity of the replaced small intestinal mixture leading to lesions in gastric mucosal barrier, is caused by an increased ability to reabsorb hydrogen ions along with migration of blood proteins and electrolytes towards lumen of the stomach. Consequently, histamine secretion becomes increased, leading to inflammatory and haemorrhagic changes or ulcer niches.The aim of the study was to demonstrate histological and microscopic changes in the gastric mucosa following reflux and to determine if long-term exposure to refluxed duodenal contents will produce tumorous changes in the organs tested.Material and methods. The study consisted of 25 mature female Wistar rats weighing 180-200 g. Bile reflux to the stomach was produced experimentally by surgical drainage. Final evaluation was performed after 55 weeks.Results. Findings were as follows: gastric changes were noted in basal and parietal cells, no tumorous foci were found in histological samples. Slight morphological changes can be caused by short periods of gastric mucosa exposure to the gastrotoxic small intestinal mixture.Conclusions. Endogenous bile acids cause morphological changes in the stomach mucosa of rats. In particular, these changes affect the ultrastructure of basal and parietal cells. No neoplastic foci were found in the examined organs.
Słowa kluczowe
Wydawca

Rocznik
Tom
79
Numer
4
Strony
269-272
Opis fizyczny
Daty
wydano
2007-04-01
online
2007-10-17
Twórcy
  • Department of General, Bariatric Surgery and Emergency Medicine, Silesian Medical University, Katowice
  • Department of Anatomy, Silesian Medical University, Katowice
  • Department of General, Bariatric Surgery and Emergency Medicine, Silesian Medical University, Katowice
  • Department of Anatomy, Silesian Medical University, Katowice
autor
  • Department of General, Bariatric Surgery and Emergency Medicine, Silesian Medical University, Katowice
  • Department of Electron Microscopy, Silesian Medical University, Katowice
Bibliografia
  • Madura JA: Primary bile reflux gastritis: diagnosis and surgical treatment. Am J Surg 2003; 186(3): 269-73.
  • Houghton PW, Mortenson NJ, Williamson RC: Effect of duodenogastric reflux on gastric mucosal proliferation after gastric surgery. Br J Surg 1987; 74: 288-91.
  • Wołfson NJ, Kalinowski WP, Płuss GB: Dynamika morfologicznych i biochemicznych zmian błony śluzowej żołądka pod wpływem żółci. Pyt Onkol 1990; 36: 1287-92.
  • Fukuhara K, Osugi H, Takada N et al.: Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy. Hepatogastroenterology 2004; 51(58): 1241-44.
  • Kawiorski W, Herman RM, Legutko J: Współczesna diagnostyka refluksu dwunastniczo-żołądkowego i żółciowego zapalenia żołądka. Przegl Lek 2001; 58(2): 90-94.
  • Thun MJ, Henley SJ, Gansler T: Inflammation and cancer an epidemiological perspective. Novartis Found Symp 2004; 256: 6-21.
  • Domellof L, Janunger KG: The risk for gastric carcinoma after partial gastrectomy. Am J Surg 1977; 134: 581-84.
  • Bielecki K: Żółciowe zapalenie błony śluzowej żołądka. Post Nauk Med 1989; 2: 105-10.
  • Kellosalo J, Alavaikko J, Laitinen S: Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa. Scand J Gastroenterol 1991; 26: 1272-78.[PubMed][Crossref]
  • Sobala GM, O'Connor HJ, Dewar EJ et al.: Bile rexlux and intestinal metaplasia in gastric mucosa. J Clin Pathol 1990; 46,3: 325.
  • Bechi P, Balzi M, Becciolini A et al.: Gastric cell proliferation kinetics and bile reflux after partial gastrectomy. Am J Gastroenterol 1991; 86: 1424-32.[PubMed]
  • Micheletto G, Lattuada E, Pozzoli M et al.: La reflussimeria enterogastrica nei pazienti ulcerosi duodenali sottoposti ad intervento di vagotomia o di resezione gastrica. Min Chir 1986; 41: 493-98.
  • Miwa K: Duodenal reflux throught the pylorus induces gastric adenocarcinoma in the rat. Carcinogenesis 1992; 13: 231.
  • Bechi P, Amorosi A, Mazzanti R et al.: Short-term effects of bile diversion on postgastrectomy gastric histology. Dig Dis Sci 1988; 10: 1288-96.[Crossref]
  • Cichoz-Lach H, Slomka M, Celiński K et al.: Level of serum cytokines in biliary gastritis and erosive gastritis with Helicobacter pylori coinfection. Ann Univ M. Curie Skłodowska 2001; 56: 271-74.
  • Sobala GM, O Connor HJ, Dewar EP et al.: Bile reflux and intestinal metaplasia in gastric mucosa. J Clin Pathol 1993; 46(3): 325.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_v10035-007-0041-7
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