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2014 | 9 | 3 | 485-490
Tytuł artykułu

Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I - dosing interval 12 h (n=8), II - 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p<0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52±0.47 l/kg, clearance (CL) 0.055±0.036 l/hkg and a half-life (t1/2) of 6.89±3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
3
Strony
485-490
Opis fizyczny
Daty
wydano
2014-06-01
online
2014-07-08
Twórcy
  • Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia, kacav@pharmacy.bg.ac.rs
  • Institute for Mother and Child Health Care of Serbia “Dr Vukan Čupić”, Belgrade, Serbia
  • Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia
  • Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia
  • Department of Pharmacology, Clinical Pharmacology and Toxicology, University of Belgrade School of Medicine, Belgrade, Serbia
Bibliografia
  • [1] British National Formulary for Children (BNFC) 2013–2014. London: British Medical Association, the Royal Pharmaceutical Society of Great Britain, the Royal College of Paediatrics and Child Health, and the Neonatal and Paediatric Pharmacists Group. London
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  • [7] Pacifici G.M., Clinical pharmacokinetics of aminoglycosides in the neonate: a review, Eur J Clin Pharmacol, 2009, 65, 419–427 http://dx.doi.org/10.1007/s00228-008-0599-y[WoS][Crossref]
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  • [11] Burton M., Shaw L., Schentag J., Evans W., Applied Pharmacokinetics & Pharmacodynamics: Principles of Therapeutic Drug Monitoring, 4th ed., Lippincott Williams & Wilkins, London, 2006
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  • [13] Vervelde M.L., Rademaker C.M., Krediet T.G., Fleer A., van Asten P., van Dijk A., Population pharmacokinetics of gentamicin in preterm neonates: evaluation of a once-daily dosage regimen, Ther Drug Monit, 1999, 21, 514–519 http://dx.doi.org/10.1097/00007691-199910000-00004[Crossref]
  • [14] Lundergan F.S., Glasscock G.F., Kim E.H., Cohen R.S., Once-daily gentamicin dosing in newborn infants, Pediatrics, 1999, 103, 1228–1234 http://dx.doi.org/10.1542/peds.103.6.1228[Crossref]
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  • [18] Weber W., Kewitz G., Rost K.L., Looby M., Nitz M., Harnisch L., Population kinetics of gentamicin in neonates, Eur J Clin Pharmacol, 1993, 44, S23–25 http://dx.doi.org/10.1007/BF01428387[Crossref]
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  • [20] Knight J.A., Davis E.M., Manouilov K., Hoie E.B., The effect of postnatal age on gentamicin pharmacokinetics in neonates, Pharmacotherapy, 2003, 23, 992–996 http://dx.doi.org/10.1592/phco.23.8.992.32877[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0298-7
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