Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
Severe thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.
Czasopismo
Rocznik
Tom
Numer
Strony
148-158
Opis fizyczny
Daty
wydano
2014-02-01
online
2014-02-04
Twórcy
autor
- Division of Pathophysiology, Medical University, Varna, Bulgaria, gabekyarova2001@yahoo.com
autor
- Department of General and Clinical Pathology, Medical University-Varna, Varna, Bulgaria
autor
- Division of Pathophysiology, Medical University, Varna, Bulgaria
autor
- Division of Pathophysiology, Medical University, Varna, Bulgaria
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0253-7